If wt within normal but high decrease = indicate endocrine problem depend in age 3-10 : thyroid or cortisol . If > 10 problem in sex hormone In a case of hight in lowest percentile but wt bellow 5th percentile (wt more to be decrease)= systematic problem (CF , renal disease , malnutrition ) If hight below 5th percentile but with normal velocity 5 cm\year its could be familiar type if within same range of average paternal hight If bellow the average = constitutional delay