Thank you so much!! You might or might not realise but never have I ever seen such a video with this level of simple and lucid explanation on physiology. Please keep up the good work. God bless you!!
Great video!!! May I ask a question that if there are any calcium ions released from the mitochondria? Is the mechanism of it as same as that from SR? Thanks a lot!!!😍
Thank you for the informative video. Does that mean reducing calcium allows smooth muscles to relax? I'm trying to understand sphincter of oddi dysfunction in which the sphincter spasms and can't relax to release the bile
12:03 how is myosin phosphorylation and dephosphorylation Calcium independent mechanism when both the enzymes are activatedby calcium+calmodulin complex ? Plz throw some light on it
I can't believe I spend two days trying to figure out how this works. Honestly I only clicked on the video cause I thought "Might as well procrastinate in a way that makes me think I am learning for the exam" You managed to get me to understand a for me really confusing topic in 12 min. And with visuals that are not trying to confuse me but actually are showing just as much as I need to understand without being too rudimentary. And all the while it didn't simplify so much it got unusable to me but also neither did you try and make everything sound overly complicated. Thanks a lot!
Great video, though a think a clarification regarding skeletal muscle contraction is needed: The breaking down of ATP is not directly coupled to the power stroke. Rather, the ATP-ase activity of the myosin head occurs before contraction, cocking the myosin head back like a spring. When the myosin head combines with actin, the already cleaved ADP+phosphate ion is released and the energy that came from breakdown of ATP is released in the power stroke.
6:48 "in addition to the replenishing the stores, the calcium in the *sarcoplasm* also rises." Sorry if this is obvious, but she meant to say *cytoplasm*.
