One of the cool things about DL - there's characters for people who like to focus on aiming, and also characters for people who like pushing a spell and recieving dopamine (aka me)
If the extra damage from mystic burst kills the hero, you wont get the souls. Same for any items that add flat or % health damage. Only "safe" way to build is to just stack spirit power. I still buy improved burst late game to make confirming kills easier but when trying to snowball with early lead I avoid mystic/improved burst