Sodium Regulation: Thick Ascending Limb 

❤❤❤❤❤❤❤❤❤ perfect explanation

Thank you so much for this great presentation....

Great class, thank you!

Please continue posting vedios.

Thank you very much man ❤️🌹

Thank you very much for the great video. I really learnt a lot from it. Still, I have a question and hope you don't mind me asking. If blocking the NKCC2 transporter would lead to the dysfunction of potassium transporter on the apical membrane, then how is NKCC2 blocker cause hypokalemia since both the in and out transporter were shut down?

At 4:03, why does hypokalemia induces cells to secrete potassium ions? Doesn't that make potassium level even lower?

this is fantastic

Doesn't hypokalemia from Bartter's syndrome come mostly from increased distal sodium delivery, causing increased reabsorption via ENaC by the CD principal cells, which increases the lumen-negative potential for increased potassium secretion via ROMK? You said yourself in the video that most of the potassium reabsorbed by NKCC2 is recycled back into the lumen to create a lumen-positive potential for calcium and magnesium reabsorption..

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Hi , if the alpha interca... cells secrete potassium in exchange for hydrogen ion then doesn't it decrease ph because H ions are reabsorbed?

Another question. At 3:45, how is lumen positive potential decreased when NKCC2 is blocked? I thought by blocking NKCC2, urine sodium and potassium levels become higher, which results in "increased" lumen positive potential?

Thank you so much!!!!!

4:50 Isn't it a sodium-bicarbonate symporter and not exchanger in the PT?

Great👍

The way Jesus made the body is awesome 😆😆