Cell biology, molecular biology, biochemistry, particle physics, quantum field theory...fascinating universe! Such intricacy for such simpleminded cultural points of view....politics come to mind! Thanks for educating about the ‘real world’.
Just a small question, sir. Despite one ORC model being the correct one, we see cdc6 loading once for each loading of mcm complex. Is it possible that there is a bit of dna looping such that one ORC can facilitate end to end assembly of mcm requiring cdc6 loading once for each mcm? Thank you for your outstanding work
What a cool complex biological machine. Or more properly, inter-related Molecular Machines. And it was developed by accident, from a pile of mud in the archean age of the world. Not bad for mud.