You are single handedly the reason I am passing immunology. Your lectures provide essential context and are so incredibly well done and engaging. Thank you so so very much, your students are so lucky to have you!
Thank you so much. I love your analogies, you have the clearest explanations (on such a complex topic) that I have ever seen! As others have said before, you are amazing and keep slaying the game :)
Let me congratulate you for your videos. To be honest, they are the best immunology videos on youtube. Thank you for taking the time to upload them. I really like how you cover most details that are normally not clearly explained in other videos or even books. I wonder if you can help me with one question. Thanks to this video I understood exactly how the two classes of memory T cells work, but I am not clear enough about how memory B cells work. Let me recapitulate, memory B cells and plasma cells are formed in the cortical region of lymph nodes after B cells are stimulated by effector T cells through CD40/CD40L interaction as well as activation-induced deaminase enzyme activation. So my question is, during the second exposure to the antigen, do these memory B cells are still in the lymph nodes where they were formed, or they are trafficking around the body similar to what Th effector memory cells do? In other words, where do memory B cells find the antigens that promote their activation during the second infection?
Hi Walter, thank you for the compliment! I love making videos to help students learn Microbiology and Immunology. Memory B cells stay in the LN. Only thing from B cells that really comes out of the lymph node are antibodies. Occasionally you can find B cells in the blood (at low levels, if they are high it may be some sort of cancer or other issue).
@@maureenrichardsimmunologym9632 I hope you can help me with one additional question please. Based on your explanation, could you please tell me if mucosa associated lymphoid tissue in the respiratory and gastrointestinal tracts are the places where IgA secreting plasma cells are differentiated in order to release secretory IgA? That way, everything will make sense 😊
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