The ‘TRUTH’ About Dopamine - The Neuroscience Behind Your Brain's Reward System

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In this video, Dr. Sanil Rege, a consultant psychiatrist, sets the record straight on dopamine. You've seen the buzzwords: dopamine hacking, stacking, fasting. But what do they really mean? And why do they often miss the mark?
Dr. Rege breaks down the complexities of dopamine and its role as a crucial neurotransmitter. Forget the oversimplifications; he dives deep into:
1. The Evolution of Dopamine
2. The Discovery of Dopamine's Role in Medicine
3. Common Misunderstandings and the True Role of Dopamine
4. The Risks of Focusing Too Much on Dopamine Optimization
5. How to Improve Well-being Through a Scientific Understanding of Dopamine
6. A Sneak Peek into Narcissism and Dopamine Levels
If you think dopamine is just the "feel-good" button, you're in for a surprise. Dr. Rege explains how this neurotransmitter shapes our behavior, cognition, and activity. He explores the evolutionary journey of dopamine, from motility in ancient organisms to its critical functions in the human brain.
You will also learn about the intricate balance required for optimal dopamine function and why simple hacks don't work. Plus, find out whether individuals with narcissism have low or high dopamine levels.
Join Dr. Rege as he unravels the science behind dopamine, its impact on mental health, and practical ways to enhance your well-being. Don't forget to like, comment, and subscribe to "Psychiatry Simplified" for more insights into the fascinating world of psychiatry and neuroscience.
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Stay curious and informed about the latest in mental health. See you in the next video!
#PsychiatrySimplified, #DrSanilRege, #Dopamine, #Neuroscience, #Neurotransmitter, #DopamineOptimization, #RewardPredictionErrors, #EvolutionaryBiology, #BasalGanglia, #PrefrontalCortex, #DopamineReceptors, #Psychopharmacology, #ADHD, #Serotonin, #Glutamate, #GABA, #Noradrenaline, #Cognition, #Activity, #Emotion, #Perception, #Sleep, #DopamineModulation, #Addiction, #RewardDeficitState, #CognitiveFlexibility, #Novelty, #Routines, #DopaminePathways, #MentalHealth, #Narcissism, #WellBeing
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Опубликовано:

6 окт 2024

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Комментарии : 60

@DennisBolanos 3 месяца назад

Dr. Rege-would you consider making a video about “predicting violence in persons with mental illness”? 🎭

@WB-63 3 месяца назад

Great video suggestion!

@PsychiatrySimplified 3 месяца назад

Yes great video suggestion. I’ll add to the list !

@andrewconnor4429 3 месяца назад

@@PsychiatrySimplified My suggestion is to talk about the LEAP method, how to speak to someone who is psychotic. Dr. Rege I'm asking you to explain to me, how do you talk to someone who has lost their mind and is psychotic and believes things that are obviously wrong, how do you handle them?

@9me9a92 Месяц назад

So grateful to have found your channel

@PsychiatrySimplified Месяц назад

Appreciate the feedback 🙏🏻

@jerryholdcroft4607 3 месяца назад

Dr. Rege, Thank you for another piece of jigsaw, in my understanding of the complex mechanisms of Dopamine, having SSRI induced EB and SD I was fully prepared to simply ask my GP for a dose of Dopamine, in my crude (at the time) understanding of depression I thought the simple release of Dopamine (the happy stuff) would be the answer. I now understand better, the real mechanisms and sequences of the processes involved, modulation is better than optimisation. I agree that the plethora of fixes and potions advertised for Dopamine is a dangerous thing, especially when there is no recognised scientific research to support them and no effective regulation.

@Truerealism747 3 месяца назад

Did you have physical symptoms

@jerryholdcroft4607 3 месяца назад

@@Truerealism747 Lethargy (lack of energy), constant tiredness and genital numbing

@Jules-kp7rw 3 месяца назад

As a person cumulating both the rigidity and perfectionnism associated with autism and the constant reward seeking state of ADHD, this resonates deeply. Finding the balance between 2 seemingly opposite traits is something I struggle tremendously with. Thank you for that video. I keep hoping to find the magic answer even though there isn't such a thing. I feel like a puppet.

@PsychiatrySimplified 3 месяца назад

I've done a few videos on ADHD treatment talking about this balance. I wonder if those may clarify a few things for you? Is the ADHD treated?

@nickibanks5185 14 дней назад

@@Jules-kp7rw ooh you described perfectly how I experience life. I have been diagnosed three times with ADHD. The first in NZ, second when I relocated back to Western Australia as they don't or wouldn't accept a diagnosis from another state or country . Then again when returning to NZ I was referred to an actual ADHD specialist and he also confirmed ADHD. However...when I read , hear see anything on typical ADHD...I don't think I relate into many of the "said" profile traits of ADHD, less so now I am ...erm 🤔...much older 🤨. I think more along autism now that trauma & the self preferred social isolation, I believe,has become the result of it. I am boring in comparison to my younger years way more introverted & can spend days alone in my room( when not at work) Listening to podcasts thinking & just pottering. Rigidity yes!! I have to do I don't become to overwhelmed & dissregulated It usually involves habbits / rituals that involve rewards & anticipation of them to keep me grounded,food in particular certain types at certain times. Yet...I can hear the faint yelling & pounding of fists of the unruly ADHD child who has been locked away immobilised for some time. I'm too scared to let it out as there will be Armageddon going on between the quiet & rigid routine patterned self & the ...to hell with it let's go run amok self 😳

@marcelneculae5651 3 месяца назад

hey Dr. Rege, are you planning on doing a similar video on glutamate (and receptors) and the proposed mecanisms of actions as an antidepressant, as an alternative to SSRIs? 🤔 also, do you know if any such compounds exited human trials and have been proven more effective than SSRI/SNRI for specific conditions?

@nickibanks5185 23 дня назад

So grateful for your content.🤯 The amount of time & variety of ADHD questions I have searched for over the years, I would have expected RU-vids algorithm to have introduced me to you ages ago.🤔

@PsychiatrySimplified 14 дней назад

Thanks for the feedback. 🙏🏻

@medichain 3 месяца назад

Great presentation! Mind bogglingly complex. Modulating the different states of mind pharmacological must be a very delicate enterprise.

@PsychiatrySimplified 3 месяца назад

Thank you for your feedback 🙏🏻

@ayeshanabeel2095 3 месяца назад

superb explanation of very complex dopaminergic mechanisms novelty, unexpected experiences, embracing change can enhance dopamine at D1 receptors its the essence of life thanks alot may God blesss you

@PsychiatrySimplified 3 месяца назад

Thank you for your feedback 🙏🏻

@func99 2 месяца назад

Dude your videos are great and awesome, exactly what we need, but i would recommend maybe a different microphone set up thats less agitating since people will unfortunately probably dismiss you with a reflexive reaction to the discordant sound. You say things bluntly and truthfully its precious. Everything else in the production is pretty great.

@PsychiatrySimplified 2 месяца назад

Thanks for the feedback. Could you be a bit more descriptive re the agitating part? Is it the entire video sound or something specific? I'm trying to understand to get it right. This video is filmed in a make shift ‘studio’ with no extra audio input so if i understand it better I can improve on it. I appreciate your feedback

@func99 2 месяца назад

@@PsychiatrySimplified hey sure, I just mean the vocal recording part after the into. It's like the ambience in the room is picked up on... So when you speak, or change the cadence/speed/vocal rigour it's reflected too much, and kind of results in an explosive sound element, it also 'clips' the high end I think, as certain vocal frequencies duplicate and overlap each other. It's just the vocal recording device which is probably incompatible with the spacey room you're in. I think a different or maybe directional mic that picks up more like a podcast would be better/solve the issue. They represents things with a pretty steady E.Q. It would then allow you to speak with any pace and all kinds of sounds recorded would be brought to a pretty close level. (And sound professional). It could also be the acoustics of the room itself if a mic swap test doesn't work. I'm not an expert on mics but I assume it's cheap and easy since almost all podcasts/explanatory videos have this quality and tone to them. I hope this helps answer things; your mixing and edits are good for makeshift, I think it's just the mic. I think that's all it is, and you could give it a test run and see if that's all it is, if it still seems too unclean , unpolished you could then attempt to experiment varying your speaking slightly. If you'd like I could even let you know next time you upload a video. Just message me or I can check your station, or you comment on any of my videos. -jonsat

@func99 2 месяца назад

Yeah it's through the whole video btw except perhaps a little of the intro(where you go through 6 points), but just the talking being recorded, there's a lot of high dynamics, which is like you're shouting sometimes. Some of the music is really well selected too, and some of it isn't, like the more repetitive ones at 2min30 and 25mins, but the one at 15 minutes is a great choice. Damn, great video again by the way.

@LucidSteve 3 месяца назад

Incredible video as all of your others. I cherish every video you post. Kudos.

@PsychiatrySimplified 3 месяца назад

Thank you. Appreciate the feedback 🙏🏼

@nivlakhera9 3 месяца назад

Love it my upcoming book is in alignment with this ❤

@studentaccount4354 3 месяца назад

Thank you, Dr. Rege. I am curious about excess dopamine and schizophrenia hypothesis I read about. I also read some other articles on scizophrenia and ph imbalance in the blood (1930) the blood was slightly acidic. Another, correlation or association was around half of patients with schizophrenia haf toxoplasmosis ghondi. Finally, I found another clue the calcium channel gateways in the cells. Clearly, there is something biochemical going on in this illness that is so complex. Can you discuss this? Elyn Saks, an attorney and Ph.D. wrote a book and did a Ted Talk about her turning point and diagnosis. I would love to hear about the scizophrenic illness and if it can go into remission etc.

@PsychiatrySimplified 3 месяца назад

Here I’ve written about the hypothesis. Yes it can go into remission and a certain percentage follows a relapsing remitting course - psychscenehub.com/psychinsights/the-dopamine-hypothesis-of-schizophrenia/

@joecaz 3 месяца назад

Learning this, nirvana came to mind. Thank you!

@PsychiatrySimplified 3 месяца назад

Pleasure

@anuullannur 3 месяца назад

I I think artha and karma are explained nicely. But the golal of these aspects is gaing kama. . And the peace that can be attained by controlling "kama" (which may have a nice translation of getting pleasure) and the perseverance to achieve the pleasure slowly convert (this seeking or/and achieving of pleasure) to the state that reduces the immense importance of the kama, which is vairgya. From here, one can choose either the path of self-realization (considered as eternal happiness or moksha ) or using "vairaagya" to get the continuum of peace in this "laugika jeevita" . If we can translate these aspects into neuroscitific language, it may give some idea of the total activity of a yogi or a gruhasta. I feel so. Since the peace, the consistency of all happiness has the balance of kama and vairagya for a laugikaperson.

@PsychiatrySimplified 3 месяца назад

Thanks for those insights. I touched on yoga / kama in the video on Ikigai. Have a listen to that as well. Your insights are very nice. Thanks

@anuullannur 3 месяца назад

@@PsychiatrySimplified drive.google.com/drive/folders/1XtcxAMgYL1-R-nOF8z7xwJxcbHV0PmHc

@wetelectronics238 3 месяца назад

Did you see the recent paper that found normal peripheral norepinephrine and dopamine in CFS but reduced spinal fluid NE and DO metabolites? Was interesting.

@PsychiatrySimplified 3 месяца назад

Not surprised but this is known and inflammation reduces this. I’ve covered it in the videos on CFS / Long Covid . Consequences of neuroinflammation in general .

@Yasen1791 3 месяца назад

Dr Sanil. When will we have new medications for Depression in Australia?

@PsychiatrySimplified 3 месяца назад

We have a lot in Australia - it’s just that not all on PBS. The treatment of depression in relation to successful outcomes is about using what we have appropriately which does make a difference. Depression consists of domains and deconstructing these domains and using medication / psychotherapy/ lifestyle changes etc to target these is necessary for optimal outcomes

@anuullannur 3 месяца назад

I mean the diagrams of the topics from 7:02 - 7:32 and 10:24 - 10:20 - 10:40 !!!

@tsu525 3 месяца назад

amazing, thanks a lot

@PsychiatrySimplified 3 месяца назад

Glad you liked it

@gpslayer 6 дней назад

Hi Dr sanil rege. This is first video i have seen from you, i have read something about dopamine in scholar literature. And I had a feeling that these dopamine detox and other advices are wrong. So i was searching for videos like yours. But it did not answered all questions, I would like to know if dopamine can be just depleted by repeated spikes from playing games for example, or it is just some other thing that is depleted. In context of ADHD i would like to know why there is a lack of motivation or why there is a state when it is very hard to work and if in this states has something to do with dopamine and if some strategy from "dopaminic videos" would work though increased ability to produce dopamine or to conserve dopamine.

@PsychiatrySimplified 6 дней назад

I’ve covered a number of these aspects across a range of videos. Partly in this video I’ve touched on the impact of repeated D1 stimulation. D1 receptor requires high levels of DA to be stimulated. They are stimulated via unexpected rewards. But the unexpected becomes expected - that’s the way we have evolved - so we aren’t exposed to multiple stimuli that create surprise ( D1 ) - associated with euphoria, surprise, curiosity etc . Repeated D1 stimulation can lead to desensitisation - so the response to DA dampens down- which can express itself with reduced hedonic drive and or decreased motivation. See the videos on ADHD - why ADHD is more than just stimulants or when stimulants stop working etc. also the impact of Meth use - hope that helps

@Truerealism747 3 месяца назад

Is this why nicotine patches help some with cfs etc as new evidence comes up as it helps dopamine

@PsychiatrySimplified 3 месяца назад

Yes that's right.

@Yasen1791 3 месяца назад

Dr Sanil, Is there a role for thyroid hormone therapy in depressive disorders?

@PsychiatrySimplified 3 месяца назад

psychscenehub.com/psychinsights/thyroid-gland-and-psychiatry/

@9me9a92 Месяц назад

Hi, what about unpredictable parents, does it decrease dopamine levels in children?

@9me9a92 Месяц назад

Like lashing out on a child and then being kind to them BCs feeling guilty. Is it considered an award?

@PsychiatrySimplified Месяц назад

You raise some very important points and it’s a theme for a further video. But in short yes it does result in a reward deficit state. I’ve covered this aspect more in the video on how Trauma ‘rewires’ the brain. Inconsistencies in parenting result in what is know as reward prediction processing duration which results in Dopamine dysregualtion. This can present with affective instability, mood swings, procrastination , self doubt and a range of ‘inconsistencies’ in self

@9me9a92 Месяц назад

@@PsychiatrySimplified thank you so much. Since ever watching your videos, some new areas of my mind have been unlocked. Thank you for sharing the professional content all for free.

@PsychiatrySimplified Месяц назад

Pleasure. Thanks for the feedback. 🙏🏻

@anuullannur 3 месяца назад

Can you send me the diagram of the different neurotransmitters that ends in the dopamine production and if possible the inhibitory dopamanergic pathway (the VMPFC, DLPFC, and Insula-amygdala pathways if I am not wrong)!

@bunnyoncloud 3 месяца назад

Music was annoying tbh

@PsychiatrySimplified 3 месяца назад

Apologies! for the whole video or certain parts?

@ryansanders2009 3 месяца назад

It’s my understanding Dopamine also plays a role in thyroid function

@PsychiatrySimplified 3 месяца назад

Yes that’s right. dopamine stimulates the production of thyrotropin-releasing hormone (TRH) and inhibits the production of thyroid-stimulating hormone (TSH). The HPT axis also regulates dopamine release.

@Truerealism747 3 месяца назад

@@PsychiatrySimplifiedthis is why ADHD causes low thyroid

@ShadowMan66 3 месяца назад

Dr Rege off topic here sorry but wanted to ask you as I am trying to come off Tramadol 100mgs twice daily due to Australian Drs only being able to prescribe it once a month as of 2020 and you have to go to the GP for this in person. Is Cymbalta a good neuropathic pain killer? My Dr has put me on it at 30mgs going up to 60mgs in a month. Have you heard of people being able to come off Tramadol opioid type drugs by reducing and substituting it with Cymbalta for this sort of pain? Having to go to the Dr once a month every month for a 30 day supply of Tramadol is getting tiresome.

@PsychiatrySimplified 3 месяца назад

Can’t speak specially in your case but yes Duloxetine is effectively used for pain and can help. However in the transition duloxetine plus tramadol poses a risk of serotonin syndrome hence has to be done properly. Also Duloxetine pain benefits occur above 60 mg. Ps not advice

@ShadowMan66 3 месяца назад

@@PsychiatrySimplified Thanks for the reply, my Dr has assessed the risk of serotonin syndrome and decided that the Duloxetine may benefit my neuropathic nerve pain and help me come off the opioids they kept me on for 31 years. What dose is considered effective to dull this kind of pain as I thought it was 60mgs?