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The Clotting Cascade EXPLAINED! 

ICU Advantage
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Discussing the complex clotting cascade. 📝 Free Quiz: adv.icu/3Px3yXI
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When bleeding is present, our blood needs to transform from a liquid to a gel in an attempt to slow and stop the bleeding. This process of hemostasis is a complex one and the most complex part of this is what we refer to as the clotting cascade. The cascade allows the rapid conversion of Fibrinogen to Fibrin, a crucial component to forming a stable clot. The cascade involves multiple steps and enlists multiple helpers to "cascade" into a large volume of fibrin. We have both the Intrinsic and Extrinsic Pathways that both feed into the Common Pathway and result in clot formation.
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0:00 Intro
1:32 Hemostasis
4:51 The Cascade
12:46 Extrinsic Pathway
14:33 Intrinsic Pathway
16:53 Entire Cascade
19:29 Wrap up
#ICUAdvantage #ClottingCascade #Hemostasis

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26 июн 2024

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Комментарии : 79   
@ICUAdvantage
@ICUAdvantage Год назад
❤ Show your support with an ICU Advantage sticker! 👉🏼 adv.icu/support 💲 10% off EACH Month @ Nurisng Mastery membership: 👉🏼 adv.icu/mastery NOTES for this lesson (and all previous lessons) are availably only to RU-vid and Patreon members. Links to join both here ⬇ ► RU-vid: adv.icu/ym | ► Patreon: adv.icu/pm
@ilonaspeicher760
@ilonaspeicher760 Год назад
@t1g3r2009
@t1g3r2009 Год назад
As a Clinical Hematology Professor, I approve! Love your videos!!!
@ICUAdvantage
@ICUAdvantage Год назад
Awesome! So cool to hear this. Thanks so much Luis and glad you enjoy them.
@ivantarandovskiy4765
@ivantarandovskiy4765 Год назад
You really approve that calcium is needed for conversion of fibrinogen to fibrin? And that platelet phospholipids are not needed for prothrombinase formation?
@josetrujillo738
@josetrujillo738 Месяц назад
You are exceptionally well spoken: you speak very clear and explain very nicely.
@josetrujillo738
@josetrujillo738 Месяц назад
It is very desirable.
@fredoxychannel923
@fredoxychannel923 Год назад
I don't know why school teachers can't explain vividly and briefly like this. Thank you man. Keep up the good work 👏 🙌 👍 👌 💪
@ICUAdvantage
@ICUAdvantage Год назад
Thanks so much for that. Really glad I was able to convey the info so it made sense.
@malikasha
@malikasha Год назад
U mean medical schools?:)
@fredoxychannel923
@fredoxychannel923 Год назад
@@malikasha yes med school,.all my doctor teachers know is to make med school a hell life.
@malikasha
@malikasha Год назад
@@fredoxychannel923 haha I see, dont give up
@nygeek6471
@nygeek6471 Год назад
Because they don’t actually know it
@christinafurneri9699
@christinafurneri9699 Год назад
Some tips to help remember : PT = tennis (played inside) = intrinsic pathway versus aPTT = table tennis (ping-pong, played outside) = extrinsic pathway Common pathway = 10, 5, 2, 1 = like $ currency Intrinsic = numbers 8 through 12 (except 10) Thank you so much ICU Advantage! You have greatly helped this pharmacist prep for hospital residency!
@ICUAdvantage
@ICUAdvantage Год назад
Thanks for sharing that! I really like the currency part! And you are very welcome. Truly happy to know I'm able to help!
@bonniehuang8696
@bonniehuang8696 Год назад
Forgive my ignorance, but I thought tennis is played outside and table tennis is played inside?
@christinafurneri9699
@christinafurneri9699 Год назад
@@bonniehuang8696 oops! True, I meant the opposite :(
@igorbesel4910
@igorbesel4910 Год назад
I am also teaching from time to time and really can´t get my mind wrapped around this cascade. Great Job wrapping this thing up.
@ICUAdvantage
@ICUAdvantage Год назад
Nice! Happy to help Igor!
@michaelmoyer1865
@michaelmoyer1865 Год назад
“All bleeding stops eventually”, is my favorite one liner
@ICUAdvantage
@ICUAdvantage Год назад
Haha yes and it’s so true!
@parkerphelps5202
@parkerphelps5202 Год назад
Thanks so much for making this video! I was just looking into learning more about this topic the other day. I definitely have a better understanding of it now
@lobarita
@lobarita Год назад
Watched and read many things trying to understand this, and this video was what put it all together for me.
@senioracademia1947
@senioracademia1947 24 дня назад
Woah, clear and concise thank you!
@Flying.thomson
@Flying.thomson 7 дней назад
Thank you very much sir for this valuable information!!
@hannahmacababbad5195
@hannahmacababbad5195 Год назад
I particularly enjoyed this presentation!
@waseemahmed6990
@waseemahmed6990 Год назад
Very logical and good explanation, thanks
@kenirole2433
@kenirole2433 Год назад
Incredibly easy to follow lesson... thank you
@ICUAdvantage
@ICUAdvantage Год назад
So great to hear this Ken!
@RdGdGW
@RdGdGW Год назад
I absolutely love your lectures.
@ICUAdvantage
@ICUAdvantage Год назад
Thank you so much Rose!
@dianachen4986
@dianachen4986 Год назад
thanks it really helped!!!
@rolandrojas8473
@rolandrojas8473 Месяц назад
Great lecture
@doc.asifali
@doc.asifali 7 месяцев назад
Thank you so much sir.❤
@abesha9928
@abesha9928 Год назад
Thank you
@fatimahassan8043
@fatimahassan8043 Месяц назад
Thank you sir 😢
@emekaanikwo8282
@emekaanikwo8282 2 месяца назад
This is awesome.❤ Thanks a lot
@MariAngelical23
@MariAngelical23 Год назад
I finally understand this!! 😊 🙏 thank you so much!!
@ICUAdvantage
@ICUAdvantage Год назад
Woohoo!! Happy to help!
@MariAngelical23
@MariAngelical23 Год назад
Your the best !
@dgmnhn2098
@dgmnhn2098 11 месяцев назад
Thanks !
@cezarzagorneanu5905
@cezarzagorneanu5905 Год назад
Loved it. Thank you so much 😊
@ICUAdvantage
@ICUAdvantage Год назад
Glad to hear it!
@faithbolding4597
@faithbolding4597 Год назад
Love your videos!! Thank you!
@ICUAdvantage
@ICUAdvantage Год назад
Thank you Faith! ❤️
@medicalchalupa9928
@medicalchalupa9928 Год назад
Started scribing in a heme/onc clinic and this video is gonna help a ton
@ICUAdvantage
@ICUAdvantage Год назад
Glad you liked it!
@collin4555
@collin4555 Год назад
Very helpful in developing my understanding of my factor VII deficiency hemophilia on a mechanistic level
@melissarainchild
@melissarainchild Год назад
thanks for explaining something pretty complex...
@ICUAdvantage
@ICUAdvantage Год назад
You’re welcome and glad I was able to do so in a way that made sense!
@MrM49901
@MrM49901 Год назад
Thabk you so much! This helps very very much!
@ICUAdvantage
@ICUAdvantage Год назад
Glad it helped!
@hersheygo7931
@hersheygo7931 Год назад
thank you so much!
@ICUAdvantage
@ICUAdvantage Год назад
You’re welcome!
@shubhangikamble3177
@shubhangikamble3177 4 месяца назад
Thank you ❤❤❤❤
@ICUAdvantage
@ICUAdvantage 4 месяца назад
You're welcome 😊
@bahiachibi895
@bahiachibi895 10 месяцев назад
🤩thanks
@kevinmills8617
@kevinmills8617 8 месяцев назад
This is excellent, from a University College London Professor of biochemistry, I also approve.
@safnasagar988
@safnasagar988 4 месяца назад
Pretty complicated but explained well❤
@ICUAdvantage
@ICUAdvantage 4 месяца назад
Great to hear! And yes, it is quite complicated!
@MrBogombo
@MrBogombo Год назад
One question, with txa it stops the process of fibrinolysis by binding with plasminogen. Why during a massive hemorrhage is the body trying to breakdown its own clots? Something I could never understand. Great videos!!
@ivantarandovskiy4765
@ivantarandovskiy4765 Год назад
Coagulation is much faster than fibrinolysis. Normally, the clot is being lysed after the vessel is regenerated. In massive hemorrhages fibrinolysis does not play big role
@elishevajoseph5301
@elishevajoseph5301 Год назад
Hello! love your videos I've been struggling with this topic for a long time. So thank you! I just have a quick (and rather dumb) question: When you were explaining the intrinsic pathway you said activated factor 12 and 11 activate factor 7 which activates the extrinsic pathway, but you drew the arrow from activated factor 9. Which one is it?😅🙈
@ICUAdvantage
@ICUAdvantage Год назад
Ahh this was my bad! It took me a minute to try and make sense of what was being asked, but once I realized my mistake it all makes sense now. I did draw it correctly, but I completely misread IX as 11 instead of 9. It is activated 9 that activates 7, along with many others. Sorry for the confusion!
@elishevajoseph5301
@elishevajoseph5301 Год назад
@@ICUAdvantage Thank you so much!!!
@rashmeechavan8745
@rashmeechavan8745 2 месяца назад
@DavidTiptonJr
@DavidTiptonJr Год назад
My head hurts 😂
@ICUAdvantage
@ICUAdvantage Год назад
Hahaha yeaaahhh...... this will do that!
@michaelburatovich3199
@michaelburatovich3199 Год назад
Every time I teach this pathway, I run out of blackboard space.
@ICUAdvantage
@ICUAdvantage Год назад
Hahaha I could see that!
@mikelestala7382
@mikelestala7382 5 месяцев назад
Notes?
@HOOPSZ4LYF
@HOOPSZ4LYF Год назад
Where can I find the notes please??? ❤
@ICUAdvantage
@ICUAdvantage Год назад
Hey Larysa! First off, thanks so much for your support! Unfortunately RU-vid doesn't make it very clear. If you go to the main "ICU Advantage" RU-vid page, then at the top look for "Community" and that is where you will find the link to the notes and the current months password. Let me know if you have any issues and feel free to shoot me an email if you still do! Thank you! -Eddie
@shreyansh_sdu_9362
@shreyansh_sdu_9362 11 месяцев назад
Flabbergasted
@thepalettewhispererasmr1227
Holy craps...that's why EDDIE WATSON is the GOAT. Complex indeed
@lobarita
@lobarita Год назад
Thanks !!!!!
@ICUAdvantage
@ICUAdvantage Год назад
Yw!!
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