The Effects of Forced Exercise on Parkinson's Motor and Non-motor Symptoms 

Many thanks for this.... I live in a small town with few connections to others with Parkinson's. Haven't figured out why I have it and have been a big health nut for decades. Ldopa seemed to do me little good but increased L-tyrosine (1500mg daily) and/or phenalalnine (1000 mg daily) DOES decrease my relatively small tremors quite a bit. Only diagnosed about 18 months ago. Smell: My dad lost his smell fairly early on and in his later 70's began to have some small tremors (he was a watchmaker and needed extreme precision). I never suspected Parkinson's - he never had any major shaking, falling, etc.. I noted your comment on not noticing body odor like I used to - extremely interesting. That maybe happening to me though I use deodorant every few days, even if I don't, I seem to have lost that ability to smell body odor and that frightens me! LOL!!! I'll correct that part. Mississippi and Atlanta have similar climates and I try to walk at least every other day, but it's cold and rainy in the winter and during mid summer gets extremely hot and muggy. Those times I have difficulty walking but may change to a stationary bike or treadmill so I can do those indoors. Caffeine, even slight amounts, can set off shaking. Years ago I noticed caffeine could set of instant rages in me for very little reason. Now I take about 25 mg from a pill to help me wake up - but within 30 minutes, the small trembling will start - sometimes a small amount and sometimes enough to make it difficult to put in my contacts. One other thing I'll bring up is I am hypothyroid. I take about 260 mg desiccated thyroid a day plus iodine. I have no idea if that has any connection to Parkinson's but it certainly helps keep my limbs from getting cold, etc.. It has made my receding eyebrows regrow to fullness, hair all over my body (especially legs) regrow and seemingly the thinning spot on my scalp. No one in my family that I know of has had Parkinson's but a number of us suffer from depression. I've taken Zoloft for many years and mention it because it might have side effects I am not familiar with that could affect the brain and dopamine receptors. The dopamine, serotonin and related brain receptors might have some part in the receptors being affected by side effects. I've never been on drugs, smoked, rarely drink. I do have Hypoglycemic condition diagnosed back in the mid-80's and get very sleepy after sugar or lots of carbohydrates. Sorry, I started this out as just a thank you for the video and felt some of these symptoms and factors might connect with other patients in clearing up these Parkinson's problems..... Many thanks!!!!!!

Thank you .very informative.

Great presentation very informative thank you

I dance to african drums, indian drums, latin rythms etc...it improves my symptoms a lot. Perhaps the rythm is a manner of "enforcing"exercise

Great talk!

love his sense of humor...

Very interesting. Thank you

I often see it's other health issues my clients are dealing with that cause them more trouble than their PD. We exercise online 2x/week. They range in age and in degree of PD. One was told his PD is benign after 6 years of working out. He's one happy 74 year old!

Funny thing is when i walk on a narrow raised platform, like a bar or a raised sidewalk curb, i lose balance easily, but if i walk across while doing eskrima motions with a sword, i dont lose my balance. Normally youd expect the opposite.

I was really excited about this when I made the connection that Davis was riding the hell out his bike. Now I don't know what to think. I will definitely continue exercising.

My grandpa has gone downhill quickly with carbidopa-levadopa and always feels better before he takes it. When he takes it he has more falls and instability!

Fascinating. Thanks for presenting this study.

the slides alluded to at the 1:28 mark are not present on the davis phinney foundation website

Thank you so much. I have a 74yo Norwegian friend with Parkinsons that I will start this type of programme with together with supplements of Lions Mane Mushroom, Co Enzyme Q10 + PQQ, sauna use and Red Light Therapy (aka PhotoBioModulation)Terrific presentation thanks so much. Brian Birmingham UK

It is medicine! Forced or not .

This is not good he keeps talking about charts that are not showing on my screen!

13:35 off DBS before ride had strong tremors, after 4hr ride had none. 16:48 initial study 2007... 19:45 assisted lower body cycling 80-90rpm (65-85% of optimal heartrate) saw incidental upper body/sensory changes ex improved handwriting. 22:40 and olfaction resurrected. 24:32 if we see these changes in upper areas and other functions of the body from assisted lower body cycling, then it must be change something in the brain.

Seeing slides would help especially handwriting results pre and post

Thank you for such a positive and informative talk. Have you noticed any improvements if people change their diets eg to Mediterranean or Keto?

Exercise is medicine

😢I work with heavy feed bags hay bales and 60 dairy goats here alone my husband died and I have Parkinsons I force myself to work and walk really far too sometimes I have to run sometimes I have a pic of an animal off the floor I have to give shots vaccines😅 that being female I might be weaker than a man lifting these things been taking care of my goats and sheep for 19 years😅 alone😅 I don't know how long I've had it I was just diagnosed last year I am on a low dosage of levodopa very interested in some clinical trials I live in live oak

e-Trike?

9

The deliberate creation of a disabling condition in a non human species and the administration of electric shocks is morally questionable. Couldn’t these trials have been directly done on Parkinson’s patients without the need for animal experimentation first?

What ppt pppp

What a terrible choice: “forced” couldn’t be more different than “assisted” or “augmented” or “helping hand”. And shocking mice into running is NOT akin to what’s going on with humans (tandem bike or motor). Please explain why you call it “forced”. What a confusing choice of terms. Yet, I’m advocate of Dr. Alberts and pedaling for Parkinson’s- but this confusing name, ”forced exercise” pisses me off, frankly.