Really informative video gents. Fabuli. 1 - Androgen Receptor Basics: The androgen receptor is a protein located throughout the body in various tissues. It binds to androgens like testosterone and DHT, leading to gene transcription in the nucleus. Androgen receptor sensitivity varies due to factors such as receptor density and the folding quality of the receptor protein, influenced by the length of CAG repeats within the gene. 2 - CAG Repeats and Health Implications: The number of CAG repeats in the androgen receptor gene affects androgen sensitivity, with implications for muscle building, risk of certain cancers (like prostate and breast cancer), and conditions like sarcopenia. Average CAG repeat length varies by population, affecting disease susceptibility and physical characteristics. 3 - L-Carnitine's Role: L-Carnitine, a small peptide, enhances energy metabolism, reduces muscle protein degradation, and increases muscle protein synthesis. It positively affects the androgen receptor by increasing receptor density and activity, thereby promoting muscle hypertrophy. 4 - Heat Shock Proteins and Androgen Receptors: Heat shock proteins stabilize androgen receptors and other proteins within cells, responding to stress. Their levels are crucial; too high or too low can have implications for diseases, including cancer. Practices like sauna use may naturally upregulate these proteins, potentially benefiting androgen receptor stability. 5 - Nutrient Timing and Exercise: Timing of nutrient intake around exercise can influence muscle protein synthesis and possibly androgen receptor activity. While there's no clinically significant anabolic window, consuming nutrients post-workout, especially with L-Carnitine, can enhance muscle building effects.
Seems there is another science based channel which I "must" watch regularly now... I like the length of these episodes, not too long, but still a lot of good information.
Wonderful conversation. Question for you (possibly for another episode): can someone be in the normal range but still be too low? For example, can the body want to be around 700 but someone's producing 500?
So how much L-Carnitine should I take orally to get benefits? I don't like to inject anything but the bioavailability of the oral L-Carnitine is very low :(
