The main challenges that remain in diagnosing AL amyloidosis 

Mario Nuvolone, MD, PhD, University of Pavia, Pavia, Italy, outlines key challenges that remain in the diagnosis of light chain (AL) amyloidosis. First, this disease is rare, and often has clinical presentations which mimic other more prevalent conditions. Furthermore, there is limited disease awareness in the medical community, and particularly amongst cardiologists, who, when suspecting amyloidosis, often first think of transthyretin (ATTR) amyloidosis. Finally, even when clinicians suspect AL amyloidosis correctly, the requirement for histological demonstration of amyloid deposits followed by the need for highly advanced diagnostic tools makes the diagnosis itself challenging. This interview took place at the XIX International Symposium on Amyloidosis (ISA) in Rochester, MN.
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