The Science Behind Ageless - Andrew Steele

Просмотров 10 тыс.

% 495

Here I had great fun speaking with @DrAndrewSteele, author of the book 'Ageless: The New Science of Getting Older Without Getting Old' and science writer and presenter. Andrew previously obtained a PhD in Physics before moving into computational biology.
Here we discuss the science behind Ageless, theories of aging, and future technology that could help us live longer healthier lives.
Andrew Links:
andrewsteele.co.uk/
statto
ru-vid.com
Get a copy of Ageless at ageless.link/
Find me on Twitter - EleanorSheekey
I have Patreon - www.patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Physics & What led you to Biology - 00:50
No thermodynamic obligation to age - 06:38
Ageless & theories of aging - 10:00
Lipofuscin and removing damage - 20:00
Why do we age? - 25:00
Senolytics, stem cells, cellular reprogramming - 29:15
Neurodegeneration - 37:00
Computational/Machine learning approaches - 41:00
Epigenetic clocks/Statistics - 53:00
Science communication - 57:30
Advice for improving health & career - 1:00:00
Icons in intro; "www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com

Наука

Опубликовано:

18 дек 2021

Ссылка:

Скачать:

Готовим ссылку...

Добавить в:

Мой плейлист

Посмотреть позже

Комментарии : 61

@TheSheekeyScienceShow 2 года назад

I hope you enjoyed our conversation! See links in the description!

@johnnyjava_ 2 года назад

Hi Miss Sheekster, I love your accent (oh, and content too :-) ). What area are you from (not stalking here). You lose me sometimes but I'm learning a new dialect. It's a skill we have here in the great "melting pot".

@DrAndrewSteele 2 года назад

Thanks for having me on your channel! It was a really great chat :)

@starryfolks 2 года назад

Good job with the interview and really inspired by the pioneers in the ageing field.

@joelmccoy9969 2 года назад

Don't interview East Texan or Louisiana scientists they are either too, too, fast or slooow!

@DrAndrewSteele 2 года назад

@James Robert Clark III Happy birthday! And hope you enjoy it :)

@themacso4157 2 года назад

Very insightful content! I hope 2022 will be a great year for science innovations

@ArticBlueFox96 2 года назад

This interview was absolutely incredible. Great video.

@SirTenenbaum 2 года назад

Thanks for the interview! Ageless was a great book and everyone should read it!

@michaelshannon9169 2 года назад

Fascinating talk. You could really sense his enthusiasm in these matters.

@elliottrubenstein1746 2 года назад

Loved interview. Thanks.

@lexosney6432 2 года назад

Good interview. Exactly what we need free thinking people from other diciplins especially scientists from a physics background.

@christopherellis2663 2 года назад

"Sticky end", recycled into Owls. My hair is regaining its colour, at 72. 💙💛❤🙏

@amperage8032 2 года назад

What do you attribute the return in your hair?Sorry, I didn’t get the reference.

@marilialevacov2939 2 года назад

Very interesting interview. As usual. I always find incredible the large number of lurkers that accompany each of your videos, compared to the number of "likes". Lurkers are typically members of the online community who observe, but do not participate by “liking” or commenting. Lurking allows users to learn the subject being discussed without letting the owner of the post identify them. They are lying hidden or moving about secretly and probably, later, some of them will be creating their own posts about the subjects and the state of the art research that you generously share online. :-)

@paulwolf3302 2 года назад

Did you see the Modern Healthspan video published today on NMN and telomeres? I was reminded of one of your older videos on telomeres, I think you said something about immune system cell telomeres being more variable or easier to repair than most, so maybe not representative of the telomere repair in all kinds of cells. Maybe I got this idea somewhere else, I don't remember. I expect they use these kinds of cells, called peripheral blood mononuclear cells, or PBMCs - because they're easy to get from blood, but it may be measuring something that doesn't occur to the same degree in other cells. Anyway, to those of us who've been taking NMN, it's surprising and exciting news.

@birage9885 2 года назад

I enjoyed listening to this guy, very good cadence and informative, and for me, easy to understand, since I sometimes have trouble listening to people with British accents {I am American}. I will have to check out his book.

@machinized 2 года назад

Superb!

@LanceHitchings 2 года назад

Great interview! How did you get him on your show? I read the book, loved it, and I've been trying for months to interview him.

@vertolive6678 2 года назад

Oh hi Lance ! I am following you in your journey! You, others and Sheekey permit to relativise aging. Keep going !

@TheSheekeyScienceShow 2 года назад

Thanks Lance, i just emailed!

@surfreadjumpsleep 2 года назад

She blinded him with science. But that wasn't a problem due to epigenetic reprogramming.

@starryfolks 2 года назад

Nice

@RobertPowellRN 2 года назад

Simple, she is amazing!

@grunta101 2 года назад

Good interview:)

@nopara73 2 года назад

This guy is great

@BitesizeWisdomForBusyPeople 2 года назад

I don't think you have done a video on Lutein and its possible role in healthy aging. Check out the study from 2019 "Effect of Lutein (Lute-gen) on proliferation rate and telomere length in vitro and possible mechanism of action". Quote from the paper...."Lute-gen’s effect on telomere attrition indicates that the antioxidant activity of lutein is beneficial and counteracts the effects of oxidation on telomeres in human primary cells." Keep up the great work! 😀

@joelmccoy9969 2 года назад

Eleonore is a known and speaks well. Her interviewees that speak in excess of 330 words a minute need a clearer picture to help read their lips simultaneously as they speak.

@donmountford797 2 года назад

I needed to play this at .75 speed tomorrow him

@SirDeeznuts 2 года назад

very interesting content 👌

@alyousuf 2 года назад

0.75x

@DrAndrewSteele 2 года назад

Hahaha sorry… :)

@miken1463 2 года назад

I think that this interview and Dr. Steele missed an opportunity to research and apply machine learning theory to the inputs (food) that people eat that form the baseline of agelessness. I’m talking about the whole food plant based diet that the longest living humans eat known as the Blue Zones. To be sure their is something happening on the epigenetic level of the people that eat a WFPB diet. I would like to know the biological mechanism that connects WFPB diet and biological age. Therapeutic drugs can only react to people who are ill and do not address the foundation of why they are ill. We know what people need to eat to lower their blood pressure and resting heart rate. Perhaps his next research topic could do this sort of work.

@perverse_ince 2 года назад

Less calories, less methionin and overall protein = less mTOR and IGF1 activity (fasting mimicking) Lots of phenolic compounds, which at least provide hormesis and at best are antioxidants, senolytics, inflammation reducing, gene repairing, Sugar binding etc Out of the blue Zones, only SDA are radically WFPB, the others include animal products, although rather sparsely.

@julioalexo 2 года назад

What do you guys think about Cryonics? I'm thinking in signing up to "Tomorrow Biostasis" for heart-brain preservation in London.

@johnmackinnon3384 2 года назад

Fantastic as always. I’m always shocked that you don’t have more subscribers. I expect that will change in big way.

@marilialevacov2939 2 года назад

However, she has thousands of lurkers.... :-(

@cascador1984 2 года назад

i feel the conversation is artificially accelerated

@dionysusnow 2 года назад

had to check, yes playback speed is set to normal.

@DrAndrewSteele 2 года назад

Definitely sensing a theme in these comments…

@immortalityIMT 2 года назад

Immortality IMT crypto for the longevity field listened to the entire video from start to end

@christopherellis2663 10 месяцев назад

Doubling each eight years us 2^(years/8) 2^(80/8) =2¹⁰ = 1024 It seems that the chances of dying are less than one.

@viktornilsson93 2 года назад

22.30, we dont need lipofuscin, we got serrapeptase. Clean your bloodvessles

@eliezerrodriguez1899 2 года назад

Entropy concept in thermodynamic is analog to senescent cells. Nature dictates that the disorder always increases in any system regardless if it's a human being. Exergy or entropy minimization probably would be analog to healthspan.

@julioalexo 2 года назад

Interesting; thanks for the clarification.

@Kaledrone Год назад

If disorder always increased in living things then living things wouldn't be born and be able to grow in the first place

@bgrune1 2 года назад

Something you are overlooking is the power of a well planned whole food plant based diet in preventing disease and disability.

@austaneousc5802 2 года назад

Not really... Wholefoods and all the good habits we have only compress morbidity. Everybody must inevitably die of some kind of deterioration in their biology. This conversation is speaking in regards to superseding the maximal health and lifespan we are currently able to achieve with lifestyle and nutrition

@bgrune1 2 года назад

@@austaneousc5802 that’s true I was more thinking about staying alive and healthy until some of the therapies in the pipeline become available.

@austaneousc5802 2 года назад

@@bgrune1 And that's totally fine, but that's just a different conversation. So they haven't really overlooked it, if you feel me.

@ivanandreevich8568 2 года назад

Great interview. Random: Andrew Steele looks like Louis from Dexter (the nerd intern).

@joeblack4026 2 года назад

Pls update your microphone/audio ;)

@mrs210 2 года назад

Evolution? Or the Creator?

@bugrasoner 2 года назад

Extremely British! 😛

@investigativereports1622 2 года назад

Oh My Gosh, he is SO Darn cute!

@saliksayyar9793 2 года назад

What is the evidence for evolution selecting for reproductive success as it a selection for individuals. Why would it select for reproductive fitness?

@DrAndrewSteele 2 года назад

Because the more kids you have, the more chances there are for them to pass on your genes!

@christopherellis2663 10 месяцев назад

I read that he thinks that 30~35 years was the lifespan in ancient times. However, two of the people in Abri CroMagnon were over fifty. Get real or get out!