The Science of Aging 

I wonder how many times a week you guys buy expo markers lol

As a scientist that's studied and researched in this field, I just wanted to say what a great explanation that was! Respect :)

LOL "why is my telemore so short..." 'you got that from your father" Come on.... We all saw that joke right??

CHANGES SEEN DURING AGING ARE- 1.Increased free radicals*& decreased levels of antioxidants. 2.Decreased expression of IGF-1 gene* 3.Increased cross linking of collagen* 4.Increased somatic mutation due toDNA damages* 5.Telomere shortening*

This makes so much sense, I thought I was part of a family of demigods because my great grandparents are currently 90 and 91, and I had so many plans with being immortal too ...

Why do we smile?

So basically, telomeres are the reason my grandma shat herself at Thanksgiving.

telomeres is the one thing that should get the most funding for research, they hold the key to the most important technology in history.

I dont wanna die amd lose my thinking forever.

I would be interested in a video about ADHD inattentive, hyperactive and combination types. I have been diagnosed as a young adult (23 inattentive type.) and it has changed my life substantially for the better I'd love to know more and understand it better and your videos do such a great job!

It is scary that one day you will no longer be conscious or alive the most scary part is that there is no way to stop it or come back

Why do stomachs growl or rumble when we're hungry..?

science. making the world better, yet when explained makes you fear for your life.

I have a question! How come humans evolved into the superior life form? Why didn't another species that has been here longer evolved?

10 years in the future: Little Jimmy suffers from premature ageing disease. At 15, he has aged twice as fast and as a result is already bald, pot bellied and somehow unable to pay his mortgage even though he still live with his parents. Doctors now have developed a revolutionary technique to slow down the ageing rate of Jimmy to that of a normal healthy person. Doctor: "Congratulations Jimmy, now you won't die at 35, instead now you'll die at 70 like you should. Thanks to science!." Jimmy: "Only 70? But my grandparents are 95." Doctor: "Yes but your genes say you should die at 70" Jimmy:"How hard is it to make it longer than that?" Doctor: "Extremely easy. We just move this slider right here. See, it's at 70 now." Jimmy: "How far does it go?" Doctor: "Up to 100 million. It could go higher but we couldn't fit it on the screen." Jimmy: "Could you make it 80 at least?" Doctor: "No." Jimmy: "Can I do it?" Doctor: "No, only a professional has the required training to move the slider" Jimmy: "Can you move it to 75?" Doctor: "No"

AGH THE BACKGROUND MUSIC IS STARTING TO KILL ME!

what is being in your 'prime' as a young adult? Why/how/are we able to classify someone's prime age?

Another thing to take into consideration. Telomeres are also negatively affected by the amount of calories that our body processes. Food intake directly affects the telomeres. People who usually eat less quantities of food without taking into account the nutritional facts live much longer than the rest of the population. It is a true fact.

why is the sky blue?

No one asks, "why does a car age after you use it for 5, 10, 20 years?" So why should the explanations for humans be any different than a machine? To ask the question seems to imply a purpose, or an evolutionary program. And the video states this as such. But no one has proved that cellular regeneration can rid the body of advanced glycation endproducts, or Amyloid for example. Those are still components of aging.

thank you guys, you've helped me with my coursework and made doing my coursework way more enjoyable

Make a video what happens when you die

I'm so scared of death

They should make more videos

"EVERYBODY GETS A TELOMERE!!!"

how would living for a thousand years (or longer) effect your memory

Growth hormones also play a vital role in aging because it is essential for development as well as biological maintenance. Growth hormones induce cell proliferation, it tells the cells in your bodies to multiply, but too much GH can be a bad thing because cells can only divide so many times.

AsapScience: We're program to die Me: *gets scared* Me*thinks*; god why! Relatives died Me cries in bathroom

Can we become immortal?

some cells, like your skin, don't need added telomere length because they are completely replaced (unless they are cancerous). Your brain cells aren't replaced. The very complex science of metabolism tries to be efficient by caring for the things you really use. Older runners have longer telomeres than sedentary people (and even grow telomere length). Maybe because running places so many demands on the body, more repairs are made using many mechanisms.

Can u make humans immortal

what is the difference between growth and aging

I'm creeped

Blood type what the difference

I'm a little confused about the 50 figure for being able to replicate. Wouldn't that mean we reached that at a really young age? Or is it 50 times after the telomere has been removed? And does that mean we all have a pretty similar lifespan once that senescence has been reached, it just means the part before it varies between each person? thanks

I don't want to die

Why does food have fat in it?

We watched this in my Gerontology class yesterday!! I was like ahhhh AsapScience!! Go RU-vid!! This video is very helpful!

aging isn't natural or positive in any way, the real question is why can't people accept that something bad happens to them so they justify aging? we need a world wide program to end aging with about 20-50billion$ of budget/year edit - actually aging is positive since if people you don't like age you benefit, like with everything, but some people make those indirect benefits to be a justification which is just so horrible imho.

I don't care if I die I just don't wanna get old.

So basically, we need to invest our money, time, energy, and resources into finding a way to make longer telomeres. They are the key to an even longer life than we already have.

i like how he neglected oxidative stress damage which is widely believed to be linked to certain disease and cancers [cancer, Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, fragile X syndrome, Sickle Cell Disease, lichen planus, vitiligo, autism, and chronic fatigue syndrome (wikipedia)] not to forget glycation, ...err chronological age also but that is a comparatively small factor.

asapscience is so enlightening and informational that i believe they (it,he,her/them) could do a lot of great things to help earth and human beings, even if theyre only suggestions. they should make videos on possibilities of time travel/how it would be possible, and other possibilities/how possible vids such as being immortal and maybe refurbishing ozone layers and cleaner resources and cloning and life on other planets and the void of space etc etc

I'm terrified now

So since my parents lived into their mid-90s, do I have a better chance of that too?

My grandmother's three sisters lived to their late 90s and she lived to 96. The youngest sister is still alive in her mid 80s the last I checked. The women on my father's side live to their early 90s. So, I might get to 100, who knows.

That is beyond our understanding. From what we know, when you're dead, that's it. Everything you were made out of, decomposes and goes back to being a non-sentient (i.e., without a mind and being incapable of thought, feeling, and consciousness) part of the universe. Hypothetically, you could reincarnate. Then again, hypothetically speaking, anything or nothing at all could happen after we die. Simply put in all honesty, we don't know, and we likely never will, at least not for awhile.

Could light photon oscillations of vibrations form the process of aging that we see and feel as the flow of ‘time’ a process of continuous energy exchange or continuous creation? With light being a wave over a period of time and a particle as time unfolds with each photon electron coupling. The electron is the most spherical object in the universe so this can form the low entropy for the increase in entropy that we have in the Second Law of Thermodynamics.

You put Aging. The proper way to spell it is Ageing.

I admire both, they have the common goal of making people smarter.

this area is still being explored, and is not understood completely, it is premature and Irresponsible to make this kind of videos

He just explained that cells will start to lose function after around 50 divisions. So once brains cells in certain areas of the brain lose function, memory starts to go.

I just listen in class, and i find this interesting so i just want to know important stuff, so i know a lot what other people must think is needless knowledge. I am only 16 so it is just how much u wanna go for it, as to know stuff like this! But i must say be careful how u do this, because your peers might not see it as a good thing to be eager to get wise. So what i did was listen at my teacher, looked up words i didn't understand or used my spare-time reading it for fun. :)

Well, aging/dying is pretty useful. Being old can mean that you cannot reproduce or help your young survive anymore, which means that you are not contributing to your species' survival. Therefore, death due to aging just helps to get rid of the organisms that cannot contribute to their own survival, and prevents them from taking away from their own survival.

this channel can be used for school! hope you guys really make it

No, their telomeres do not physically get passed onto you when you are conceived rather the genetic material for creating telomeres gets passed on so however long their telomeres are initially will affect how long yours are.

Humans are exposed to a yellow star(sun) everyday so we get radation from a yellow sun but if we were exposed to a red star could something happen to our cells, could we become more superhuman like or would we just die of due exposer to a different star??? plzzzzz do one on this I really want to know if my theory is right plzzz and thank you

Is it a coincidence i just saw an ad that says "Life is Short" next to the video

I think this is their one video with a LOT of misconceptions. First of all, cells don't stop replicating when telomeres run out. They still replicate; you just start losing functional DNA, which is what causes actual problems. Cancer does not "evade" cell death; in fact, it quickens it because of the rapid reproduction shortening its telomeres. If a tumor is benign but in an inoperable area sometimes doctors will leave it in knowing it will die if the cancer does not spread.

Can we be Immortal?

can you please do a video on mitosis and meiosis. We're learning it at school and I can't get my head around it! Thanks x

So, if you put your brain in a robotic body to become an 'immortal' cyborg, what would happen with the brains aging? Would it eventually die as well? Or is it possible to live 'forever' that way, theoretically?

What are the exhaustive reasons scientifically for human death The exhaustive reasons for human death are complex and multifaceted, influenced by a wide range of scientific factors. Some of the primary factors include: 1. Aging: As the body ages, it becomes more susceptible to various diseases and degenerative processes, contributing to mortality. 2. Disease: Infectious diseases, chronic illnesses (e.g., heart disease, cancer, diabetes), and genetic disorders can lead to human death. 3. Genetics: Genetic factors can predispose individuals to certain diseases and conditions that may impact their lifespan. 4. Lifestyle choices: Habits such as diet, exercise, smoking, and alcohol consumption can significantly affect health and mortality. 5. Environmental factors: Exposure to toxins, pollutants, radiation, and other environmental factors can influence health and life expectancy. 6. Accidents and injuries: Accidental injuries, including those from accidents and violence, can lead to premature death. 7. Healthcare access: Access to healthcare, quality of medical care, and timely medical interventions play a role in mortality rates. 8. Socioeconomic factors: Socioeconomic status, education, and living conditions can impact health and life expectancy. 9. Mental health: Mental health conditions, if left untreated, can affect physical health and contribute to mortality. 10. Lifestyle and dietary habits: Poor nutrition, lack of physical activity, and obesity can increase the risk of various health problems. These factors interact in complex ways, and individual circumstances can vary widely. As a result, the reasons for human death are multifactorial and influenced by a combination of genetic, environmental, lifestyle, and healthcare-related factors. ChatGPT ❤❤🎉🎉

Omg I love you guys! Keep making these videos!

another correction it really matter not the lenght of telomerate but levels of telomerase (preserves the length of telomeres across cell divisions). he should have also spiced up the topic with stem cells and the most favored topic of all "women tend to live longer than men"

You should answer: How do we become self driven?

ASAPscience, you are my heros

life makes sense now

Did you know that animals such as naked mole rats can actually re-grow it’s telomeres but that does not mean they are immune to harm

I love the handwriting

This is going to help with my assignment sooooo much!

To give your life meaning

You can only make a copy of a copy so many times before the instructions get blurry...

That is why tsundae is not immortal even though she have young body and power

As far as I know, lobsters are considered immortal can live for hundreds if not more years. What i want to know is how? What makes them 'immortal', and why cant humans do the same.

I don't know the accuracy or relevance to for this information, but its predicted technology to halt aging will be possible around 2045. But again, don't know about accuracy but the fact that we may see something like this in our lifetimes may be possible.

I hope someday we can learn to control our cell divuson

I don't understand how the Hayflick limit affects aging. Take skin cells. Every cell in your skin is replaced about every 1-2 months. So if the Hayflick limit determines that a cell can only replicated 40-60 times, and our skin cells are replicating every 1-2 months, then why do we still have skin after age 10? (2 month replication x 60 replications = 10 years.)

The Science of Anxiety/Anxiousness.

Then there's "Defying the Odds" - mind over matter per se.

''we're programed to die'' these words freaked me out...

That was just one factor of the whole process of aging :D

Yet, I noticed a huge difference in noticeable signs of agimg AFTER peri-menopause. So, there's more to the process of aging.

Posted on my birthday. Mind=blown

Time is the real Terminator. Spares nobody. 🤔

ah! i've seen this one answered on someplace before, answer depends on wether they ever were able to see, a blind person who was born blind would feel his other senses in his sleep (hearing, smell, touch, taste) while someone who like, got his eyes stabbed out could still experience dreams, as you don't actually see them with your eyes

Gravity pulses down and time pulses forward. Pulse gravity up and time backwards (correct mass and energy needed(kinda like radioactive decay)) and you have something to test on biological growth.

If we find a way to regenerate telemeres, will we obtain some form of immortality?

Honestly, I would much rather live forever with a higher chance of getting cancer than die at a mesurable age.

Death is a natural part of life and shouldn't be prevented! Out of every ending their is a beginning always remember that.

I'mm not certain but I've heard that blind people dream only sounds, it sounds pretty plausible to me since one of their strongest senses is their hearing and one of the instruments for them to perceive the world the world around them. it seems like sounds would be one of the things they would use to recall life and past events with.

Make a video about acne, why we have it, how do we get rid of it and what a pimple actually is

So, if we found a cure for cancer, we could begin researching ways on how to keep telomeres and make ourselves immortal. Oh. My. Fucking. God.

Im not a geneticist but why do we leave off the end of the chromatids when replicating and just fix that?

So , when telomeres are ' consumed ' do cells stop dividing or do they divide but not efficiently ? Because how does a cell realise it no longer has a telomere ? And does that mean that whenever extra division in my body is required i'll live less ? And if cells divide 20-50 times , how is organ transplant considered beneficial ? Doesn't that mean it's already expired some of it's time in another person's body ?

Aging sure can be frightening. Man, I hope I have a very short life. I never thought I would live past 17 but here I am many years later. Science, what the hell can it do? Can it save you from eternal damnation? Dear God, please allow me to live as short a life as possible. I can't think of any reason why I have to be here. There is no point in waiting any longer. They have all rejected Love and Purity and embraced Satan.

It is objectionable wording to say that we are "programmed to die". A much more accurate description would be that there was not adequate evolutionary selective pressure or means to make our biology sophisticated enough to avoid aging. Evidently for flatworms there was. But we don't have to die of aging; rather, ti is an extremely difficult engineering problem yet to be solved,

If we have a biological clock, this must run at a constant or average speed which is affected by genetic make up as well environmental factors. So, is there a way of slowing the clock down? A way of prolonging life. Would our other organs like lungs, heart or even the brain be affected? Would our motor functions slow as our cells slow in production? Amazing concept to think about.

Life is like a time bomb it keep ticking until it blows.

I learned about this in my AP bio class!