Treatment options for patients with LBCL who relapse or are refractory to initial treatment 

Tycel Phillips, MD, City of Hope, Duarte, CA, discusses treatment options for patients with relapsed/refractory (R/R) large B-cell lymphoma (LBCL). For patients with primary refractory disease, CAR-T therapy is often recommended, but if it fails, chemotherapy with bendamustine and polatuzumab may be more effective than bispecific antibodies. Patients who relapse after initially responding to CAR-T might benefit from CD20/CD3 bispecifics. If these are ineffective, alternatives include loncastuximab tesirine, the combination of rituximab, polatuzumab, and bendamustine, or lenalidomide with tafasitamab. The ECHELON-3 trial (NCT04404283) also highlights brentuximab vedotin plus lenalidomide and rituximab as an option. More treatment options are available for those who relapse after a year. This interview took place during the 2024 American Society of Clinical Oncology (ASCO) Meeting in Chicago, IL.
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