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Type I hypersensitivity (IgE-mediated hypersensitivity) - causes, symptoms, pathology 

Osmosis from Elsevier
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Комментарии : 614   
@augustocoelho2447
@augustocoelho2447 7 лет назад
I got scared at the bee time😂😂😂
@laradicecubicadi216
@laradicecubicadi216 6 лет назад
fuck me too
@kundynsingh8455
@kundynsingh8455 6 лет назад
Me too 😂
@nabeelmohdrafi
@nabeelmohdrafi 6 лет назад
Lol...me too... I was looking around of what it was
@taylorbrady4213
@taylorbrady4213 6 лет назад
Scared the absolute SHIT outta me...
@imenehinague5728
@imenehinague5728 6 лет назад
ME TOO x'D
@dayapreetsinghsodhi7658
@dayapreetsinghsodhi7658 6 лет назад
Short , simple and crisp ,, nicely made videos , you people cover everything that the topic needs , love 💌
@mima8960
@mima8960 5 лет назад
That was phenomenal 😱😱 nooo words to say 🎩🎩🎩🎩
@norka3322
@norka3322 7 лет назад
Pharmacy student here to say thank you. Good luck to everyone who is having exam soon like me.
@ebunoluwaajayi8849
@ebunoluwaajayi8849 7 лет назад
how can i get more of his videos
@QSR369
@QSR369 8 лет назад
nice... which software did you use?
@osmosis
@osmosis 8 лет назад
Camtasia and Sketchbook
@soniyaandcousins9887
@soniyaandcousins9887 7 лет назад
Tq so much
@riyag5773
@riyag5773 5 лет назад
God sent
@dr.chinmayjain6541
@dr.chinmayjain6541 6 лет назад
Awesomosis👌
@Ryma907
@Ryma907 5 лет назад
I can't imagine how people used to pass exams before osmosis.
@bijayanandanayak3116
@bijayanandanayak3116 3 года назад
Yeah man
@adamjensen4109
@adamjensen4109 3 года назад
i know I'm kinda off topic but do anyone know a good site to stream new tv shows online ?
@mdarbaz5506
@mdarbaz5506 3 года назад
Bcos of book dude😂
@leizero
@leizero 3 года назад
There's this process called "reading" and things called "books". While doing the process, comprehension is necessary to understand the things being read. Once stored inside the organ called "brain", you can retrieve the information and apply it when answering exams. Hope this helps!
@edinapercsi9364
@edinapercsi9364 2 года назад
well I guess they could pass but they didn't enjoy studying that much without osmosis, love you guys, thanks agaaaain
@hamzah580
@hamzah580 7 лет назад
anyone else jump when hearing the bee sound!
@laluna5548
@laluna5548 4 года назад
I got so scared omg
@hasanmustafa9071
@hasanmustafa9071 4 года назад
I
@ANGEL-dn3pr
@ANGEL-dn3pr Год назад
Samee
@joannakarwowska
@joannakarwowska 3 года назад
This is the best! BEST WAY OF EXPLAINING, BEST TYPE OF VIDEOS and BEST LEARNING METHODS! THANK YOU! As soon as I have money after graduation I'll support you :)
@osmosis
@osmosis 3 года назад
Thanks, Joanna! Our pleasure to be of help in your studies! 🥰
@sftx87
@sftx87 8 месяцев назад
Have you graduated yet? :)
@ericthebikeman8559
@ericthebikeman8559 5 месяцев назад
@@sftx87 I bet she graduated. SHE WOULDN'T FORGET ABOUT HER PROMISE, WOULD SHE?
@virajkeskar
@virajkeskar 7 лет назад
This is amazing. Especially when you add sound effects somewhere makes us feel like sticking up with the topic more. And being MBBS student, we have more topics to cover up in limited time; which OSMOSIS channel is making it simple. Thank You for such a nice gift. Keep uploading and helping us :P
@hokagedes2207
@hokagedes2207 Год назад
6 years ago...hmmmm I'm hoping that you have become a very successful Doctor ^^
@shivi733
@shivi733 Год назад
@@hokagedes2207 Nice way to pass time....btw I am doing exactly the same 😉
@hokagedes2207
@hokagedes2207 Год назад
@@shivi733 Well Goodluck, I hope you become successful in your career, if that is what you meant by "nice way to pass time, im doing the same"
@Christmas7731
@Christmas7731 8 лет назад
had a 90 min lecture on this today ab you explained better than my lecturer, in 9 min!! omg thank you!
@mmedrano21
@mmedrano21 6 лет назад
AthenianLove 2 reasons: 1- the person who can break down a complex process is simply smarter than the person who makes that complex process exceedingly complex and convoluted. 2- the person giving the lecture, along with the faculty of a given institution feels the need to justify themselves, their education, and their job by taking a topic that could probably be understood by a middle school student, and removing any context by breaking it up into their constituent parts; consequently, breaking up what should be very clear and concise material, into pieces that we have to, unnecessarily, put back together, ultimately, wasting our time, money, and confidence. I suspect the publishers of the books play a role in this as well. After all, it’s much easier to sell books at a premium price, along with often unnecessary revisions, when the material is put together in this convoluted manner. It’s all a racket that is sanctioned by the department of education.
@Ur1z13l
@Ur1z13l 6 лет назад
Lol Cracked me up! Tellin' it how it iz
@elyseb.-m.7148
@elyseb.-m.7148 6 лет назад
TOTALLY TRUE.
@upsideuop833
@upsideuop833 6 лет назад
Jamille Vicente Teachers at uni in your country explain u smth?! Wow!
@jessintaoseni1354
@jessintaoseni1354 6 лет назад
@@mmedrano21 Thank You! SMDH
@rawrNinjaAmbush
@rawrNinjaAmbush 7 лет назад
This is literally the cutest way possible to summarize my lecture. I WISH MY MAST CELLS ACTUALLY LOOKED LIKE THAT. Also thank you because I need this for my Immunology final
@hellobro2465
@hellobro2465 2 года назад
I passed my 1st year medical exam just because of osmosis, Revisiting this video, cuz I am in love with the presentations and the simple but powerful illustrations....thanks man for whatever you're doing...you are saving the lives of countless medical students all across the globe...keep up the good work, lots of love from India🇮🇳
@osmosis
@osmosis 2 года назад
Oh wow, your comment is much appreciated! Thank you for letting us know that we're able to help you in your medical journey. More power to you! 😊
@UpliftedBrother
@UpliftedBrother 2 года назад
7:20 that bee sound scared the crap out of me
@valeriavilla9848
@valeriavilla9848 3 года назад
loved the video, but the ilterleukines secreted by the TH2 should be IL-4, IL-5, IL-13 instead of IL-10.
@LAisyourgirl
@LAisyourgirl 7 лет назад
As a veterinary student this was by far the most efficient and informative video I've seen on this subject. Thank you for going in depth enough for the medical professional , yet keeping the topic simple so I could understand the big picture concepts!
@osmosis
@osmosis 7 лет назад
That's what we strive for! Thanks for the kind words, LAisyourgirl! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on RU-vid? Check it out here: bit.ly/2u35D6J
@DamjanPeshovski
@DamjanPeshovski 2 года назад
I'am also a Veterinary student and this is way better explained, and it helps with making a concept from all that information in the books. GOOD WORK!
@jessalysilva4853
@jessalysilva4853 Год назад
Why can't my book be this simple??????????
@sheilanwachukwu7155
@sheilanwachukwu7155 7 лет назад
I use youtube to study a lot ..... literally it feels like you took my professor's words out of her mouth... you could not have explained it better, I could give you a hug.
@arsalanijaz6469
@arsalanijaz6469 8 лет назад
On robbins general pathology 9th edition page 111 it says IL-13 not IL- 10. Please confirm it.
@mrcash9898
@mrcash9898 7 лет назад
On Abbas Immunology it says IL - 13 as well. IL-13 is produced by mast cells and helps triggering Th2 differentiation, B cell isotype switching for IgE, mucus production by epithelial cells (this aggravates asthma and rhinits) and alternative activation of macrophage. This alternative activation of them stimulates fibroblast to produce collagen, hence promoting fibrosis in the long term. Cheers from Brazil!
@wanderyonder1
@wanderyonder1 7 лет назад
if you search the literature, you will find IL-4, IL-5, IL-10, and IL-13 (among other minor things). so the answer is both are right, and it depends on what people prioritize in their presentation
@tinanoona
@tinanoona 7 лет назад
Yup, you're right.. In my paper, i discussed IL6 too in urticaria. depends what's our focus.
@jayy2451
@jayy2451 7 лет назад
IL-10 should actually be helpful to reduce inflammatory response as it induces Treg differentiation...
@zaphodflys
@zaphodflys 7 лет назад
Yeah IL 10 is anti inflammatory, or at least that's what I learned
@AK-ms5ou
@AK-ms5ou 2 года назад
when the bee sound came, I thought there was a bee in my room and got scared
@mitsukislife
@mitsukislife 4 года назад
WOW that bee sound scared me SMH LOLLLLL I had to come to the comments to make sure I wasn't crazy 😂
@raazaaaa
@raazaaaa 4 года назад
What is the tool u use for these lectures. Plz reply
@barberj1945
@barberj1945 4 года назад
Type 1 hypertensitivity Sucks , I'm living with it😭
@AbhishekYadav-hs4ix
@AbhishekYadav-hs4ix 2 года назад
Same here Brother. My symptoms are recurrent coughs when exposed to the allergen.
@pomboe
@pomboe 8 лет назад
please keep doing this man. I already suggested your vids to my classmates who will take the philippine nursing licensure exam and told them your vids are a great help to them
@osmosis
@osmosis 8 лет назад
Thanks so much for recommending our videos to your classmates. If you're interested, we can keep you in the loop on what we're doing regarding nursing stuff if you email hi@osmosis.org.
@marwahany100
@marwahany100 7 лет назад
What about treatment with desensitization method do you have an idea about it ?
@celileon2682
@celileon2682 7 лет назад
what if you have crazy high IgE count (11900+) and sudden onset of severe asthma.... but no other abnormal blood work. cause of symptoms and high IgE remains unexplained. Any ideas?
@MikoSantos
@MikoSantos 3 года назад
Who else is not a student and is watching to understand their own allergies? 🙋
@anuragsosa
@anuragsosa 3 года назад
Not me lol 😂
@5minutebiology
@5minutebiology 2 года назад
The finest channel i can rely upon when it comes to clearing concepts..hats off😊😊
@osmosis
@osmosis 2 года назад
Wow! Thanks for this feedback! 💕
@jerejh3
@jerejh3 7 лет назад
that bee buzzing sound scared the shit out of me omg needed that haha was abt to fall asleep in the med library
@54jb3r7
@54jb3r7 6 лет назад
I love your vids. Final year of medschool and wish I had found you sooner. If I need to review something (or in some cases learn fresh!) this is an excellent resource since it covers the basics. Should you feel you need to go more in-depth there's no shortage of resources but simple and clear quality introductions like these are hard to come by. Amazing.
@brettlee6211
@brettlee6211 5 лет назад
thank you sooooo much for this, you are quite litterally the living mesiah to all medical students around the globe
@emilystevens5739
@emilystevens5739 4 года назад
These videos help me more than my actual pathophysiology professor does, thank you for your service.
@amanibenyahia7014
@amanibenyahia7014 6 лет назад
thank you a lot for the amazing explanation but i have a question : what does cross-linkng means exactly ? i couldn't understand it :'( could you explain please ?!!
@zakihallaq4305
@zakihallaq4305 6 лет назад
awesome video, are you sure though it's IL-10 and not IL-13 that help naive t-helper to defferenciate to Th2
@CorvusHyperion
@CorvusHyperion 3 года назад
I wouldn’t describe allergic rhinitis as a mild symptom, it can be debilitating. I’d much prefer anaphylaxis to a single allergen than severe chronic allergic rhinitis. Long term airway hyperreactivity is associated with long term lung impairment via small airways disease also.
@sbgrfschelbergen746
@sbgrfschelbergen746 4 года назад
Excellent overview. Almost feels I shouldn't try and explain it myself in class (Lecturer Life Sciences at bachelor level)
@বাংলারসুর-জ৬ঢ
Thanks for such clear explanation.I am suffering from IgE mediated hypersensitivity.I use to have 9 times the normal IgE level in my blood when I suffer from Allergic Rinitis.I think the only cure is to take regular medicines to control it.
@iAR187
@iAR187 4 года назад
that bee sound was the scariest thing I have ever heard on youtube. I jumped out of my chair and threw my expensive headphones lol
@Shacni.
@Shacni. 3 года назад
Hahaha same here
@ashvw
@ashvw Год назад
Great video! I like how you explain everything simply and with great visual aids. I am trying to inform myself about how allergies work after recently being diagnosed with Alpha-gal Syndrome and this was very helpful. Would you please make a video about exactly how Alpha-gal works and how it ties into everything in this video. Thanks!
@osmosis
@osmosis Год назад
Thanks for your recommendation, Ashley! Our team will be taking this into consideration. Have a lovely rest of the week! 💖
@ashvw
@ashvw Год назад
@@osmosis Thank you for considering it!
@angeknowsit
@angeknowsit 7 лет назад
thanks so much, i can finally understand inmunology :D hope you deliver a lot more videos like these ones THANKS!!
@melylacheb
@melylacheb Год назад
Life saving even after 7 yrs 😮❤
@osmosis
@osmosis Год назад
Still our pleasure even after 7 yrs 🙏🏼
@chris123abc
@chris123abc 6 лет назад
I've read from a medical textbook that there is another way for the B cells to get activated and have class switching occur. The "primed" T helper cells can also physically present the antigen to the B cell, inducing antibody class switching. (Robbins Review of Pathology 10th edition)
@jamesfagbuyi4085
@jamesfagbuyi4085 6 лет назад
That bee sound effect almost made me snap my neck the way I turned my head XD Loved the video though :)
@LeTrashPanda
@LeTrashPanda 2 года назад
For those of us who suffer from this, it happens in milliseconds, it's too late once we've been exposed (even by something in a room that isn't nearby)....great vid, btw. This applies to Long Covid.
@KadeKurved
@KadeKurved 2 года назад
What issues do you suffer from?
@s.shivani7245
@s.shivani7245 2 года назад
My ige is above 5000 and I have itching .are they both connected?
@nc5809
@nc5809 4 года назад
Yeah I never studies for my exams I just substituted my schoolbooks for my pillow. Worked great
@Anand_619
@Anand_619 Год назад
Why won't this histamine bind to h2 h3 and h4 receptors ?
@alchemistarts7381
@alchemistarts7381 5 лет назад
I bet these 181 dislikers are definitely management students 😂😂 🙊🙉🙈
@sagepara
@sagepara 3 года назад
No, they may be having the allergy.
@cxlmski2556
@cxlmski2556 8 месяцев назад
The bee noise nearly had me break my chair 😂
@therightchoice100
@therightchoice100 8 месяцев назад
it seriously made me jump out of my seat!!!! LOL
@ummbreebree
@ummbreebree 7 лет назад
I liked the sound effects :D
@carolclark5776
@carolclark5776 2 года назад
You guys are great and don’t sound all arrogant. It’s refreshing learning. I am finally getting hypersensitivity reactions. I would be glad to donate
@ZdrytchX
@ZdrytchX 6 лет назад
I assume cortizone is a type of corticosteroid. I've used it a lot in te past and honestly It's great in the short term but actually seems to have a negative effect in the long term where my skin becomes hihgly dependant on it. Is there a better long term solution?
@HurricaneQueen777
@HurricaneQueen777 5 лет назад
Amazing. I subscribed immediately. Thank you!💕
@davidmilovanovic1246
@davidmilovanovic1246 5 лет назад
An hour of difficult research explained perfectly in 9 minutes.....
@nopparatjantadet998
@nopparatjantadet998 5 лет назад
Thank you guy , you are awesome. I’ve made it clear in 9 minutes.
@wladyslawjagiello
@wladyslawjagiello 3 года назад
I have sky high IGE, IGA and IGG, a high viral load, an active viral load, etc. since I was a child. My life is spent trying to detox and testing in the allergist's office.
@gbengajohnson4721
@gbengajohnson4721 3 года назад
I'm using this opportunity to appreciate Dr. Anii on RU-vid for his Herbs Medication that i used in curing my Herpes infection. I feel so Happy All thanks to Dr.anii for his wonderful work you can as well contact him now for help. stay safe stay blessed
@AbhishekYadav-hs4ix
@AbhishekYadav-hs4ix 2 года назад
Suffering from high IgE levels. My symptoms are recurrent coughs. Have you been able to find out the specific allergen of yours?
@ozzlicious
@ozzlicious 6 лет назад
This video is so incredible. It's informative, and I love the animation.
@realpionear9847
@realpionear9847 5 лет назад
I literally thought hipersensitivity was being way too much aware of the environment then you should
@biancarus1354
@biancarus1354 5 лет назад
3:33 in my book is: IL 4, IL5 and IL13 😖
@ananhassan3016
@ananhassan3016 4 года назад
same
@nadanadaa4770
@nadanadaa4770 7 лет назад
Perfect ! you answered all the questions that were going on my mind and I couldn't find answer to regarding this topic.
@Bhh-j2s
@Bhh-j2s 8 лет назад
Very well explained thanks
@kimli913
@kimli913 8 лет назад
Med student here: I thought that Th2 cells secrete IL-4, 5, and 13 (NOT 10). IL-10 is an anti-inflammatory interleukin. Can you comment on that?
@osmosis
@osmosis 8 лет назад
Many cell types secrete IL-10, including Th2 cells. www.ncbi.nlm.nih.gov/pmc/articles/PMC2118719/
@edwardcorty6003
@edwardcorty6003 8 лет назад
The video doesn't say that Th2 cells secrete IL-10. It says that IL-10 is floating around and helps "convince" a naive Th cell become a Th2 cell.
@manishapanda7077
@manishapanda7077 7 лет назад
Osmosis can you say wht are the biological significance of hypersensitivity?
@peanutbutter3392
@peanutbutter3392 6 лет назад
the real contention in this video should be about allergic contact dermatitis caused by latex and rubber and etc on skin.... these are type 4 (delayed type reactions) and should not be in this video
@헤린송-o7i
@헤린송-o7i 7 лет назад
you explanied in 9 minutes what my professor mumbled for 2 hours about .you are saving my immunology test , thank you
@marielpacheco
@marielpacheco 8 лет назад
Very good for teaching! THANKS!
@osmosis
@osmosis 8 лет назад
Thanks!
@abhijithvv2706
@abhijithvv2706 5 лет назад
Do a video about elisa test
@ellohappy
@ellohappy 18 дней назад
that 7:20 fake Bee Buzz GOT ME! I tensed up and freaked out in the library because of y'all! (don't worry, I'm not planning on going into emergency medicine)
@yyy3845
@yyy3845 6 лет назад
IgE (antibodies) attach to mast cells, which makes mast cells secrete histamine. Histamine is an organic material that is excreted to protect yourself, and results in inflammation. I think that's basically it! I've watched this video to understand my allergies, and my blood test result tells me that I have loads of IgE in my body!
@AbhishekYadav-hs4ix
@AbhishekYadav-hs4ix 2 года назад
Have the IgE levels come back to normal or are they the same? I too have high IgE and need some advice. My symptoms include recurrent cough.
@abhijeet8604
@abhijeet8604 2 месяца назад
Great video, makes it easier to learn. Best video for understanding hypersensitivity (including the videos on type 2 and 3)! But i have to point out, IL-10 is an anti-inflammatory cytokine, it helps in terminating inflammatory/allergic reactions. I don't remember its role in promoting inflammation so if there's any please correct me (also correct me if I misunderstood the video) :)
@dianamollo8156
@dianamollo8156 4 года назад
I've learned so much more from this video about what happens to my body when I get my rhinitis allergic reaction than what the doctor explained me. Thank you
@MMTT193
@MMTT193 7 лет назад
Amazing explanation! You literally make so many concepts incredibly easy to understand thank you so much : )
@docteura8823
@docteura8823 7 лет назад
although i study medecin in french .. but i liked watching your explaination .. thank you
@xnaox
@xnaox 7 лет назад
I had to do a presentation on IgE and the molecular basis of nut allergies and this video helped so much. I wouldn't have understood much of anything without this video. Thank you, you explained it so well!
@TheMattJames
@TheMattJames 2 года назад
eczema is NOT a type 1 hypersensitivity
@jeanyalmega
@jeanyalmega 8 лет назад
thank you so much for your explanation in this video! it really helps me so much!! :)))
@osmosis
@osmosis 8 лет назад
Thanks Jeany. =)
@biomedicelly
@biomedicelly Год назад
Are you sure that IL-10 is a pro-inflammatory mediator?? My professors have taught us that it is anti-inflammatory? :(
@SA-uw1wc
@SA-uw1wc 8 лет назад
This is the best channel on youtube
@osmosis
@osmosis 8 лет назад
Thank you!
@jenc2669
@jenc2669 6 лет назад
Wow, I been reading my notes for hours and this videos really understand the topic. Thank you.
@Nothinghere42345
@Nothinghere42345 2 года назад
This is the kind of allergy I have when it comes to Milk and Wheat and I have severe Mood Symptoms when I have Milk
@evagold5221
@evagold5221 8 лет назад
really great job! and very nice in my eyes !
@osmosis
@osmosis 8 лет назад
Thanks!
@leoashcroft7165
@leoashcroft7165 2 года назад
Bro at 7.21 I literally ripped my headphones off I thought there was a wasp inside them
@MusicIsMyLife31x
@MusicIsMyLife31x Год назад
This is extremely helpful but that bee sound made me jump so hard when I was drinking my tea.
@burakcaliskan5857
@burakcaliskan5857 9 месяцев назад
Does this mean I won't have an allergic reaction the first time I get stinged by a wasp ? because you said the fist time is sensitization ?
@gracepichlmann2615
@gracepichlmann2615 8 лет назад
Please do all the hypersensitivities!! Preferably before Monday.... I have an exam then tehehehe
@osmosis
@osmosis 8 лет назад
They are coming, but we won't be ready for your Monday exam. Sorry!
@gracepichlmann2615
@gracepichlmann2615 8 лет назад
hahaha thats ok! Thank you for the video!! They are awesome! :)
@idrisjohow6404
@idrisjohow6404 2 года назад
Easier than it sounded while listening to my prof....great work
@osmosis
@osmosis 2 года назад
Glad to help, Idris! 💕
@saranawzad7019
@saranawzad7019 6 месяцев назад
It is 100 times better than our doctor, which is do not explain any single thing about that
@screamtoasigh9984
@screamtoasigh9984 4 года назад
Err. In MCAS, you can get degranulation without IgE binding.
@cantwaittodietoday9924
@cantwaittodietoday9924 4 года назад
I love kind and eccentric people not sure why psychiatrist like to target them always trying to portray them as mentally ill and always socially inadept when they are actually they are brilliant people
@Kaizen747
@Kaizen747 2 года назад
My ige count is off the charts and i cant find out why, probably a food allergy, im allergic to wheat
@neemabisht9091
@neemabisht9091 6 лет назад
Please make a vedio on determination of blood by method of absorption inhibition , absorption elution and mixed agglutination asap I need it plss
@Dr.Mnemonics
@Dr.Mnemonics 8 месяцев назад
everything is coverd and good presentation but IL13 is missed
@srita.k9780
@srita.k9780 5 лет назад
whats the difference between IgE, IgG, and IgD? they all look the same to me
@peterking64
@peterking64 4 года назад
Great Vid, is saying genetic predisposition is the cause for all allergies not up for debate?
@hangoo91
@hangoo91 Год назад
I couldn’t get it how the body is react to this substance offffff 😢😢😢😢
@ertugruler9170
@ertugruler9170 5 лет назад
Great way to learn. When i am studying it's always makes me so happy and makes easier thank u osmosis
@MrFlyingDutchkid
@MrFlyingDutchkid 6 лет назад
So.... Are the co-stimulatory molecules on the antigen-presenting cells the actual first reason for developing the allergy? Since those will only be on their surface 'if the person is allergic'? Without those co-stimulatory molecules the naive T helper cells wouldnt become Th2 but the normal Th1?
@doctorjunaid3924
@doctorjunaid3924 Год назад
Can any body explain me difference between allergy and hypersensitivity
@hetvikhetia4354
@hetvikhetia4354 Год назад
You are amazing !!! Never stop teaching !!! Thank you so much
@osmosis
@osmosis Год назад
Always glad to help, Hetvi! 🌟
Далее
Hypersensitivity | USMLE
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