Important point that I picked is patient cannot be criteria guided, they can present different from books description. So until we seek new things and anticipate discovery, we can't find something new treatment means of helping patients.
Agreed. He's getting older, looks pudgy, and would probably benefit from 150 min cardio per week (to improve cognitive functioning in older adults -- multiple studies, pubmed). But his point that antidepressants are more harmful than American psychiatrists are trained to believe is valid: they induce manias, psychosis, and worsen the natural course of a more benign disorder -- were it were treated with mood stabilizers to begin with. (Source, me: Mass Gen/McLean post-residency fellow at UCLA.)
