Cellular biology is so complicated, however there are less than a handfull of true experts educating people about our metabolic functioning. I'm so happy to see uric acid functions finally being added to these educational discussions. Insulin, Uric Acid, Leptin, among others, are multifunctional components to metabolism and really have to be understood how they interact and modulate metabolism and thus health on every level. Knowledge allows you to know how to manipulate your metabolism to achieve optimal cellular function and thus optimal health. Thank you.
Yes I thank this channel for knowledge!!! I was looking for culprits, but at the end I pray to God our good giving father for help and guidance. And it’s I myself that has to learn, maybe read, maybe listen. Pointing my finger at the supermarkets or food manufacturers will not help. How can I cook more fresh and healthy. What food is tasty, sustaining and long term healthy? Today my supermarket gave me a free coupon for their cheap burger buns or a can of peas. And even for free I won‘t touch it - why should I take *poison* just because it’s free or *cheap* Sirs and Madams? The chemically glued sugars of the burger buns will hurt my intestines, spike my insulin like a diabetic and ruin my gut wall for several days. The gluten will inflame even my brain for weeks. The lectins in the peas are activating and spiking my immune system because of the lectins and pesticides. If a food is more poison than health don’t touch it. Frickin Change Your TV program to Dr. Perlmutter, Zoe, ‚Good Energy‘ and all their friends 😘😘😘
I got gout 2 years ago during the holidays. My Doctor stated it was due to shrimp and high processed meat consumption. I wasn't eating any of that but I was eating a lot of sugar because it was during the holidays. I quit eating the fake sugar and only consuming fruit and I haven't had it ever since.
I used to eat ground turkey for breakfast. I started having joint pain after a while.. I stopped and the joint pain went away. Lentils did that to me as well.. but now years latter lentils don't bother me anymore. I eat ground turkey from time to time.
I walked around 15 yrs ago or rather I limped around for a full year. I tried everything I was told by so many people. Pasta only, chicken only etc. What worked for me is one day a co-worker said to me "its probably all the soda you drink everyday that is causing you to limp around like that!". I battled back with the but its diet soda argument. A week later I was on my way home and stopped at my usal stop before heading into apartment and purchased my diet pepsi big gulp. Got home, took my shoes off and raised my aching feet on my desk and started sipping on the big gulp and it hit me like a warhammer! I went into bathroom and flushed the massive diet soda down the drain. 2 days later I was at work and a co-worker says....hey your not limping!!
I've been working on my uric acid for years since Drop Acid came out and I've collected several years of blood tests. I enjoy other vices, but my fructose intake has been on notice!
I wonder what percentage of leaky gut is caused by the ingestion of microplastics that are now prevalent in our organic food?🐸❤Excellent discussion, thank you
1 standard drink is .5oz pure alcohol, and over 14 standard drinks a week is considered a heavy drinker. A 6oz pour of 13.5% ABV wine is .8oz alcohol or 1.6 standard drinks. So 2 of those a day is over 22 standard drinks a week which is well into heavy drinker territory, not moderate. “Heavy drinker” is far less alcohol than most people associate with heavy drinking. 2 actual drinks a day is almost always more than 2 “standard” drinks a day.
I listened to a utube webinar by Dr. Richard Cywes and he claimed that all consumed purines has a much lower affect upon raising uric acid than our own catabolism or our breakdown of our cells as they get renewed. He claimed this was based upon his experimental observations. I’m just talking about the purines. He claimed that ingesting purines from meats and so on have a hard time getting through the intestinal blood barrier assuming the intestinal barrier is healthy. What is your take on his statements? But he did agree that sugars particularly fructose has by far the greatest affect upon raising uric acid levels.
a long while back when I was in the military I was hospitalized for massive swelling in my leg by some unidentified infection. I was on longterm intervenious antibiotic, maybe penicillin, then a number of other antibiotics via injection. Eventually the swelling went down and I was discharged (after over 20 days). I soon found I could not eat solid food. Just clear broth. This went on for weeks before I could eat semi normal again. To this day I have had a irritable bowl and have developed a wide range of inflammation and autoimmune conditions. Could my gut health been compromised?
You could have had lyme disease and may have contracted it again. Most doctors do not know about it. Please just send your blood to Igenex Labs in California or order their new kit for blood testing for lyme and other tic diseases.
The antibiotics will have seriously impacted your gut bacteria (microbiome). If you haven't already supplemented with probiotics maybe you should. Make sure there is a wide variety of gut bacteria in the supplement beyond lactobacillus acidophilus. The microbiome is responsible for most of the body's serotonin production along with being vital to the functioning of the immune system.
@@joyshuman2727that's ist t do it's a lot of peope starting place then Trial things n?where did you travel to what is prevalent there metals check high or low ?
N you're imune system will be shot after that like the person above said y imune system will be shot y need to restart rebuild y fighting system it takes a while to do and fresh
I noticed that fructose is a ketose sugar and glucose is an aldose sugar. But is I think also a ketose like fructose. Does allulose or other ketose sugars also raise one’s uric acid? Or because of its particular stereochemistry of hydroxy and hydrogen groups, they will not get metabolized the same as fructose ???
Controlling blood sugar are you better off having more sugar say 200g-300g at one time than over a week of more higher spikes. Does it make a difference? Is one worse than the othet?
try a strict therapeutic ketosis diet. get his ketones high. the brain prefers ketones for fuel. Alzheimer is known as type 3 diabetes. a friend's husband had 2 strokes, was on insulin, metforman, bp meds, OZEMPIC. he was wheelchair bound couldn't function mentally. within a month, he was off all the T2 meds, losing weight, coming back mentally and gained mobility. Good luck. it is a lifestyle change.
That says it all. No fruits, no seed oils, no veggies, no grains. If it Flys, swims, roams the land or the barnyard, that's what humans are designed to eat. If it comes in a box, bag and/or has a barcode, that's what you do not eat, as a general rule. Granted meat and dairy has barcodes, but only if you buy it from tge grocery store. I eat wild hunted animals, eggs and as much dairy directly from the farm which not every person can do. I'm 73 and my doctor, on Wednesday, just 2 days ago, confirmed that all my systems, especially my brain is functioning as a super healthy 30 year old. I'm living proof the carnivore lifestyle IS the proper human diet. I hope this inspires you. Find what works for YOUR BODY. 😅
But other are OK to help I eat liver and heart small amounts until I feel better eggs then salads but low spinich on the uric acid greens we have lots that don't cause uric acid nuts n mct oil for the brain not loads n inter mitant fasting to help body refresh its parts? With a try
I see alot of people in the comments making excuses for their carb/sugar addictions ! No fruit is required for humans. Can we eat a few fruits ? Sure, but fruits are not required to be completely healthy, ive went long periods with them. But eat berries and occasionally a few other fruits.
Can time-resolved and localized measurements of uric acid or other metabolites near cells help in understanding the effects of uric acid? I’ve been working with localized measurements, and uric acid has become an interesting target. However, I don’t have a strong background in biochemistry or biomedicine to fully grasp how this could be useful.
This actually is true. Increased water daily and one food free day per week would reduce people's weight and help uric acid levels but you have to change your diet to prevent gout. Red meat cut it right back to 2 days a month. Higher visits to McDonald's KFC Burger King have given people obesity problems world wide. Reduce that fast food visit and don't ever regularly take your kids 😅
And all the millions of people who don't live in your bubble ??? Tracking blood sugar with a CGM is beyond the means of the average person.... Here in Canada a CGM is nearly $100 from Walmart for 14 days.... and a organic turkey from super market is $70... for organic veggies , you would need to get a second or third job ....
They're just giving you the answers. They can't our terrible system. I do not own one of those machines, I just control my blood sugar through diet. Healthy fat, fiber, protein each meal. If I have a snack, I have it after eating a high protein meal. Consume less than 20 g sugar per day (I don't always do this because I eat a lot of fruit but this is the aim). Apple cider vinegar. Walking after a meal. The machine they mentioned gives perspective and motivation to ppl, that is why they recommend it. Even for a month bc it provides a lot of details on how out meals affect us during the month. But it isn't needed if you already know. I have a simple finger prick machine and use it when I've gone off track with my diet and am curious. I can tell where my blood sugar is sitting now based off how I am feeling.
It's basically the ultimate elimination diet. Problem is like some people that want the magic pill to fix their issues, this way of eating will give you that same sense of healing. Not everyone reacts the same way to it either. We have to think is it really healing if you have elimated all major offenders and eat strictly meat forever. Sounds like a magic pill to me. Great to utilize when trying to heal but I think it's more important to understand what actually went wrong and heal that so you can incorporate a variety of foods. Plus I ran across several videos chronologically listing people and their time of death and all the longest lived people were plant based. Actual people as evidence.
Always is interesting and helpful to hear what Dr.Perlmutter and Dr.Rick Johnson have to say about ... Fructose/Uric acid/Mitochondrial metabolism; thanks for your presentation
Fructose is also the biggest contributor to Advanced Glycation End Products. Fiber or any complex polysaccharides will modulate the large intestine microbiome to produce, through fermentation, much greater numbers of short-chain-fatty-acids (SCFAs) which then increase serum GLP-1 as well as providing many other broad health benefits.
I eat a few blueberries and peaches 🍑 in season…my blood 🩸 sugar does not go up… I don’t have to lose weight.. in fact I have to be careful I don’t lose weight..
It doesn't matter if you are a healthy weight. The majority are metabolically unhealthy. When I weighed 110 lbs, I had hashimoto's hypothyroidism and blood sugar issues. Mine would drop, I wouldn't catch it high very often. Now years later - I put my AD in remission, but if I go off track with my diet, my blood sugar will go to 8. Isn't good for someone who eats perfectly everyday to balance blood sugar.
Dr Ben Bikman, who wrote Why We Get Sick, talks about it in this video minute 30. ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-Eh6pg3jBPEk.htmlsi=bTW86Hlfq9KrBrso Hope this helps!
Fructose is still the main problem. Your body makes fructose which metabolizes into uric acid especially if your blood glucose is not very well controlled. Then the uric acids makes your liver produce more gluose which makes more fructose. Stuck in a fructose loop. I have this problem.
I’ve tried a low-carb diet and even switched to a carnivore diet, but my uric acid levels remain high. Although many people have claimed that the carnivore diet helped them, it doesn't work for everyone. :(
Meat, especially entrails, some fish, high fructose beverages, legumes, alcohol. Try avoiding white flour, not carbs in general. Avoid regular and diet soda. As little beer as possible - not even non alcoholic. Stick with water, unsweetened tea, coffee. Milk is fine, in fact dairy products in general - low fat dairy products specifically. Eggs are fine, too. If your liver and kidneys are healthy try nettletea from time to time. That being said you can have pretty much everything if your general daily diet is "good enough". The key is moderation. A gout patient.
Re: C-section, be mindful that anesthesia drugs get passed through to breast milk. And, when a mother doesn’t nurse and uses formula, do you know what’s in your baby formula? Is the carbohydrate GMO corn? Corn syrup solids?
Another reason that C-section incidence is at 30+ percent is because they stopped teaching how to do difficult deliveries in 2005. That information came from a nurse friend of mine. I’m sure Dr Perlmutter is right in stating that women are not in great health, which makes delivery more dangerous.
And what is a mother supposed to do? Yes that is the case and those drugs take a while to clear, the breast milk is mist definitely affected even in taste.
Amazon doesn't offer uric electronic acid testers. There are some websites sale some models but there are no reviews available. Anyone?.... any recommendations about device to monitor uric acid?
I was confused by your comment that fructose is directly metabolized to Uric acid. There is no nitrogen in fructose. It took a while to find the answer. ATP -> ADP -> AMP -> few steps to uric acid.
Surely it's certain fruits ,,, fructose is turned to sugar and sugar feeds cancer it is also energy but all our fruits are now big fuller of sugar and we eat to much try sprouting 😅
The suggestion to stop eating sugar, starch, salt and umami flavored foods as suggested in another uric acid video I watched is kinda crazy as that leads to a place of having nothing to eat anymore. I think a starch and meat aka a very low fructose diet is ideal for this. Recently, after 6 months of intense joint pain with some walking around with crutches sporadically I delved into my food list and found a whopping 100gms sugar per day. Hot sauce, pasta sauce, and a bit of fruit were the culprits and cutting everything out fructose wise gave me great relief.
Grains can have glyphsate spray to dry and feed to cows it can be in . Cows n bullocks eat grain then we drink eat meat it's second hand in our food but Europe, has stopped glysophate so should be OK here ?
Can time-resolved and localized measurements of uric acid or other metabolites near cells help in understanding the effects of uric acid? I’ve been working with localized measurements, and uric acid has become an interesting target. However, I don’t have a strong background in biochemistry or biomedicine to fully grasp how this could be useful.
When I visited the Republic of Georgia, my host's mother had the unsavory responsibility of taking me to the hospital after I sustained a minor foot injury. As anyone who has been the recipient of socialist healthcare understands, I was expecting to hunker down in the waiting room for the entire day. After we checked in, I told her I was concerned a doctor might prescribe an antibiotic as a prophylactic (I was barefoot in a swamp...don't ask). She shook her head, said don't worry and told me all about phage therapy! She said she never needed antibiotics until she came to the States, ha. The way she pronounced "phage" really had me scouring the internet, though. I couldn't find anything about it for years. I asked every doctor I came across if they knew about it; no one did. Love Dr. Permutter's mention, here. Utterly confused by its under usage. Anyway, I didn't need antibiotics or phages since she ran into an old fling (who happened to be a doctor there) and flirted us out of the door in 20 minutes.
Yes, stoping carbs and sugars saved my life. No more gout attacks, restless leg issues, and extremity infections and so on. Eat healthy fats and proteins and a few yummy low carbs veggies from time to time. I reversed type two on this plan....Love this guy....thanks
The only fruits I eat are berries. Should I eliminate raspberries, blackberries, or blueberries on my Keto/ seafood, OMAD diet? I don’t eat added sugar, no dairy, no wheat, no starches, no grains because of my Hashimoto’s?
It all depends on their knowledge and experiences in certain areas I m taking turkey tail mushroom tablets and turmeric and cucumin , black pepper tablets n beet tabs t help fight cancer n leaky heart valve probs how can we get to the truth ot all about proffits a lot of the time a nd inter mitent fasting is another to try triall and error is life
Any comments on Nutritional yeast? I have a very low fructose and no meat diet and no alcohol. Yet i still need uric acid meds. Nut yeast seems to be very potent. As you said, yeast is very membrane heavy
Can you explain why smoking cannabis creates a strong craving for chiefly sugar and if one does eat after smoking cannabis, does the THC have an effect upon uric acid levels or our metabolic functions particularly within the mitochondria as well as the whole cell itself???
A basic command to the first created man, but he disobeyed, and now mankind is destined to live a short life, followed by death. Gen. 2:16-17. And the Lord God commanded the man, “You are free to eat from any tree in the garden; but you must not eat from the tree of the knowledge of good and evil, for when you eat from it you will certainly die.”
I noticed that fructose is a ketose sugar and glucose is an aldose sugar. But is I think also a ketose like fructose. Does allulose or other ketose sugars also raise one’s uric acid? Or because of its particular stereochemistry of hydroxy and hydrogen groups, they will not get metabolized the same as fructose ???
To help with my metabolic problems (fatty liver, insulin resistance, gallbladder, etc.etc.etc) I started with Keto, six hours feeding Intermittent fasting and full body workout and cardio exercise. Two years later I started to add some carbs ( limited potato, etc.) and some fruits limited. Basically, once you fixed your problems you need to start to introduce different foods to keep your body metabolically adapted. No sugar or processed carbs ofcourse.
Sugar and vit C have the exact same pathway to the receptors that take these two items to the cell. Trouble is there is a lot more carbs being eaten and because we need far less vit C the sugar is getting into the transformers instead of the vit C . because the carbs crowd them out. It's like a dozen obese people getting into an elevator and a couple of very thin people trying to get in at the same time. Carnivores don't get scurvy because they don't eat carbs. Therefore the vit C doesn't have to fight to get into the receptors to be taken to the cell. The little vit C they get from animal products is sufficient because in actuality humans only require a very small amount of vit C. You need a lot of vit C foods because you are competing with sugar. All carbs are glucose. As soon as say bread for example goes into the mouth and mixes with saliva it turns to glucose in nanoseconds. @@stnln2180
You hesitate to say alcohol is poison for our body, but talk about gut permeability as a common natural condition. Better mention what are causes for gut becoming permeable.
Been keto/ketovore for one year. I eat zero sugar. I do drink red wine once/twice a week. My uric acid level (taken last week) was 7.1 mg/dL. For the most part, all I eat is meat, some veg and peanuts/walnuts. Where is my elevated uric acid level coming from? Not from fructose.... because I don't eat any.
@@BillyBoy66 @Always-xl9db Organ meats, alcohol and seafood and fructose are high in purines. Purines and pyrimidines are fundamental components of nucleotides in DNA and RNA and are essential for the storage of information in the cell. Only disorders of purine metabolism will lead to increased amounts of uric acid in blood and can result in gout.
