I belieave that Each episode take a different timeline from the MCU movie, ep1 is from Captain America the first Avengers movie, what if Peggy Carter take the serum. And then the episode 2 they have what if with different title and take the scenario from one of MCU movies and so on. Gamora with thanos glaive is one of many timeline in MCU, There is not one timeline but many. Also Josh Brolin is back for thanos voice actor.