Why do Chemists Care SO MUCH about Transition States? 

You are the best chemistry teacher...

In the category of science videos, I give this one an Oscar for screenplay and production. I also nominate the team for Noble price in education-

I understand almost nothing about chemistry, but I love your videos! Just a suggestion... could you keep the inline text for longer? I always have to pause the video to read them fully 😅

You never fail to provide (in my opinion) the best kind of education on general chemistry, so a thousand times thank you for that! At 2:11 there is a slight error: this molecule is called "acetyl chloride", not "acyl chloride". "Acyl chloride" is a type of compound, whereas acetyl chloride is this specific compound. Acetyl chloride is a kind of acyl chloride. It's like with squares and rectangles: a square is a kind of rectangle.

I love how detailed you go into these topics.

I’ve watched a few of your videos recently, and I think that this one is a masterpiece which manages to touch so many points in sufficient details, despite that they all have their dedicated videos.

CARBOCATION REARRANGEMENT MY BELOVED

This is insane content, I'm so happy to have discovered this at the exact right time when this channel is active.

Sir you are the best, I have hated chemistry then tried to understand it and now After learning from you, I love it.❤

15:39 "*plus some minor details"... I spent probably a year getting through those "minor details" for my PhD thesis 😅. Have you ever considered making a video about TS as bottlenecks instead of active complexes? (to include reactions that happens without an energy barrier)

It's always interesting to visualize how molecules form and the transition state. you made it easy to understand. I've always loved your videos. Thanks

What a treat, thanks. And again, I learned something new. I am solving a related mechanistic problem for months now... I've read in some old articles that oxalic acid can be reduced by active (dissolving) metals despite this is generally not possible with carboxylic acids. I've done the experiment using magnesium in cold saturated oxalic acid. Indeed it produced glyoxylic acid - an aldehyde! And virtually no glycolic acid, glycolaldehyde or ethylene glycol - which is even more puzzling. To this day however, I still struggle with explaining the reaction. Indeed the aldehyde exists as a hydrate, the very reduction is possible because of the unusual electrophilicity of oxalic acid, saturation of the solution and low temperature, further increasing the polarisation of the molecule. What further helps is the acidity of oxalic acid, so we probably have slightly soluble magnesium binoxalate intermediate rather than insoluble oxalate. And finally, the magnesium glyoxylate is a soluble complex! It allows simply filtering off any magnesium oxalate left over and the filtrate is indeed strongly acidic, more than acetic acid, suggesting glyoxylic has been produced. I have even prepared its bisulfite adduct, confirming there is an aldehyde group. I will probably prepare this delicate compound using periodate cleavage of tartaric acid or by ozonolysis of fumaric acid (maleic would be ideal though I don't have it at hand). The simple and cheap preparation with magnesium and oxalic acid intrigues me and I still don't have full explanation - even AI chatbot is confused, sometimes confirming and sometimes denying - but experiment is king and at least this is very practical to quickly prepare glyoxylic acid for e.g. Hopkins-Cole test for tryptophan. In early days, the reagent has been prepared by leaving a bottle of acetic acid sit on a window on sunlight for couple days. The UV rays did its work and the little glyoxylic acid produced in the acetic was enough for the test to work.

As a computational chemist, this video hits hard

PLEASE make a video about pyroelectric and thermoelectric materials you can also talk about piezoelectric materials but I’m specifically interested in pyro and thermo

I have found your channel recently. And as a chemistry student i can say with certainty that you're channel is absolutely great

Brilliant and simply explained. Thank you for sharing your valuable time and knowledge.

My best chemistry teacher! Please make video about quantum chemistry

WOOOOH!!! Thank you for another video!!

I enjoyed your story telling. wonderful!

Amazing! I never realized that chemistry is actually geopolitics.

so basically they all stick together and twist around and contort and thats how catalysts make your products faster. neat.

❤ I was waiting

Always interesting trying to understand something this complex, watching it from Three Twentysix! Would love to watch a series on learning Chemistry from you. Really struggle with Le Chatlier's principle. Although I do understand it to some degree. Just started today Organic Chemistry, and will have my first exam maybe sometime during the next month. Things I find hard; Identifying the limited reagent Redox reactions and redox numbers to name a few. (Yes, I am very new to this).

Sir i love how you present your videos, in a simple way with great facts and funny line. Love from India

I hold much intrest regarding this topic

Kindly make the detailed video of why nitrogen so stable as you promised

another LIFE video, yay

I'm just wondering how hard it is to find the amount of energy, at least theoretically, for a particular arrangement of atoms in a molecule, and to find the lowest energy path to do a step of the reaction.

Great video! All the subtitles are a little bit ahead though, its a bit distracting 😅

Biological transmutations -Louis Kervran Read it.

Please make video on Aromaticity please

Please do a video on enzymes eventually

We probably need to dissect one to find out. Or waterboarding might work.

A video on spontaneous and non spontaneous reaction

My takeaway from this video is, my shocking grade in Chemistry was down to my textbooks.

Weirdly relevant to what I’m studying right now although enzymes in this case but they act as catalysts so close enough.

Can you explain electron spins please? 😅

Can you synchronize the subtitles?

Florite is when the dog catches its tail, then explodes.

*Acetyl-Chloride?

You Just got a haircut, so in a transition state back to your classic look.

Me in the beginning: why not use NaOH

Please

based

Fiiiiiiiiiiiiiirst❤