I will have to be honest though, I'm not actually interested in Danganronpa itself, only in Sayaka. So naturally, her death is the only one that affected me, and I don't particularly feel sad toward other characters' deaths. (Celestia is the only minor exception)
I imagine this is how the conversation went between Mondo and Chihiro in the "S" universe, where Mondo didn't have the stress of exposure looming over him. Obviously, there would be some differences, but the general reactions would remain the same: the shock, the initial "Haha, good joke" denial, the realization, and finally, the acceptance+support. Of course, this would probably go for any interaction that involve a reveal like this. It's just a matter of how the characters treat this new discovery.
I bet Chihiro is just listening to all of Makoto's advice being like "Wow, this bitch is just making shots in the dark, he has no clue what my goal is"