The videos accompany the text book ‘Molekulare Onkolologie’, 3rd ed., published in the Georg Thieme Verlag, Stuttgart, Germany. In malignant tumours, pathways that control cell growth and cell death are disturbed. In addition, the communication between tumour cells and their environment is altered. In order to interfere with pathways governing malignant growth, the molecular basis of the pathways should be understood in detail. The videos intend to serve this goal. Once the pathways can be targeted, new therapeutic options for cancer patients may ensue.
Update 2017: New videos are available accompany the textbook ‘Cancer Signaling: From Molecular Biology to Targeted Therapy’, published by Wiley-VCH in 2017. The link is posted under the "links" section.
THE AUTHORS: Prof. Dr. med. Christoph Wagener Prof. Dr. med. Dr. rer nat. Oliver Müller
This brings to mind the words of the Psalmist……..”I will praise you for I am fearfully, and wonderfully made. Marvelous are your works and that my soul knows RIGHT well”! PWG
LOL @ "homogolous" rather than "homologous." Feels like when Bush says "nucular" instead of "nuclear." ....Otherwise a very helpful video xD Thank you!
The way you guys illustrate the beauty of chemical structures dictating the faith a human life (such as the case of threnonine 315 to isoleucin mutation) and that we can overcome such destiny thorugh the deep and detailed scientific knowledge behind pathophysiology, biochemstry and pharmacology is so awesome. it's hard to find content like this
Could you please explain a mutation in this particular pathway? I assume activation of the PKC pathway induces Raf kinase, thus induces the kinase cascade and induces cell growth. So I would assume that a mutation in PKC would lead to no cell growth? Am I correct?
