The tumour suppressor protein PTEN HD 

The phosphatase PTEN dephosphorylates PIP3 to PIP2, which can then be hydrolyzed to DAG and IP3. In addition, PTEN performs many other functions by binding to and activating or inactivating several nuclear proteins. Through these effects PTEN activates DNA repair and inhibits proliferation and thus acts as an important tumor suppressor protein.
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