RU-vid channel for presentations at the Nephrology Grand Rounds at the University of Ottawa. This will feature select presentations from the grand rounds, and are meant for educational purposes alone.
Hello my daughter have xlinked alport syndrome 1 is she is hearing from 50 db in right ear, ledt is fine...is this cause kidney issue in both ? On one kidney? Whixh medicine is suitable for her
AFIB has been on the rise globally. A huge jump in cases of AFIB across the globe was in the year 2020. G5 began to deploy in 2018 and world wide in 2019 In 2020 , G5 is in every hands of cell phone owners. AFIB rates have surged worldwide, notably spiking in 2020 alongside the widespread deployment of G5 technology. This significant increase in AFIB could indicate a potential correlation between the two. Either that or it might be my gas station sushi I had last night.
morbidly obese with BMI >40 - feel femoral has multiple issues - just going to be moist once the pannus falls back on the catheter post placement, more issues with kinking and need to keep the leg straight. agree planning for a future access but no one size fits all. More obese - more likely IJ
Sorry my question is it convenient to remove temporary line and insert permcath during bactreamia? As our center refused until culture becomes negative
Long term use of Ace inhibitors cause severe damage to the kidneys as shown in a recent study, especially when already hypoxic. Most women are asymptomatic in the more common XLAS, so the risk of Ace inhibitor damage is probably much higher than potential benefit in that group. Since at birth the basement membranes use a different fetal collagen 112 network, not only in Alport disease, I wonder if those are just more susceptible to iron like in other fetal/nonfetal cell diseases. 21:16 indeed she just said it. Yep, serum iron reduces collagen production, so presumably in particular a1a1a2, and increases MMP: Effect of free iron on collagen synthesis, cell proliferation and MMP-2 expression in rat hepatic stellate cells, 2002 17:44 this bell curve is much too wide. The 95% confidence interval is at most 40-60% for x inactivation at 100-200 embryo cells, which should hold also at tissue level. So the right side is very rare. 29:48 to update recommendations based on a handful of patients is absolutely ridiculous, in particular when it involves a very mild form of the disease that wasn't even included in the trial. I thought panels always scream for more data. The non randomized arm with slightly larger numbers did not even show a statistically significant difference, and an endpoint of proteinuria is hardly what matters 34:40 people should really be told that you should not exercise 48 hours before a proteinuria test. I believe the recommendation is 24h. Exercise dramatically raises protein in urine many fold even after 30 hours. 39:53 bardoxolene basically is just a patentable version of oleanic acid (olive oil). The trial was successful increasing egfr. Yet the fda wanted to 'see more data' and denied drug app. Oleanic acid also activates nrf2, and has been shown before to improve ckd. So this seems to work pretty well then, olive oil that is, in Alport. A similar compound was shown to reduce fibrosis, and bardoxolene was shown to improve pulmonary hypertension in connective tissue disease. 41:33 more patients were actually dropped because of elevated liver tests. These, like proteinuria, can be elevated, for over a week after exercise so maybe the people on the trial just felt better and worked out. The patients with more complications were in the placebo group.
I am 41years old. My gfr is 84. My urine is very foamy. My dna report shows homozygous variants on my col4a4 gene. My doctor said i have no blood or protein in my urine
Sir i am suffering by alport syndrome since childhood I am 19 now I had by kidney transplant 1.6 years ago and i am fine now After my transplant my hearing loss is decreased from 62% to 53% and i wear specs now
yes you would have an element of natural immunity - but natural immunity is not durable (ie wanes with time) and may not be protective to all variants out there.
