NROChemistry YT channel is a space for people interested in learning organic and medicinal chemistry. The channel now focuses on providing insights on different topics:
1. Synthesis and mechanism of action of commercial drugs. 2. Total synthesis of natural products. 3. Named reactions + mechanisms.
Obtaining primary amines from nitriles requires ammonia presence (or other organic base), not acetic acid; Additionally raney nickel requires really high pressure, over 30atm, not just baloon.. Did You received anything beside starting material here?
This is a crazy synthesis! Great respect for the chemists who developed these methods, they are very impressive. The design and scaffolding work that went into this is just breathtaking and very admirable. Thank you for posting!
While reading about the topic, I found that the preparation of these biased opioids has been a matter of controversy. It remains uncertain whether they genuinely enhance therapeutic effects while mitigating undesirable side effects. Nevertheless, substantial research is needed in this domain, and I also hope that a viable solution to this problem will eventually emerge.
Hi. The reaction conditions are available in the SI of the reference paper. I see now that the acidic proton of the terminal alkyne may be problematic; however the reagent is commercially available. To ethynylmagnesium bromide (200 mL, 0.50 M in THF, 2.00 equiv.) in THF was added CuCl (2.48 g, 25.0 mmol, 0.500 equiv.). The mixture was stirred for 15 min under argon before substrate (8.74 g, 50.0 mmol, 1.00 equiv.) in THF (25 mL) was added. The reaction was stirred at 50 °C for 6 h until it was quenched with saturated NH4Cl (50 mL) and H2O (200 mL).
Thank you always for the great videos all the way from Japan! Can you tell me why the secondary alcohol dont go through appel reaction in the second step?
