पार्किंसन बीमारी में दी जाने वाली दवाओं को जानिए | Dr. Kamal Singh 

In this video, Dr Kamal Singh speaks about various medicines used for the treatment of Parkinson's disease.
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Parkinson's disease is incurable, but symptoms can be managed through medications and, in advanced cases, surgery. One common medication is carbidopa-levodopa, which increases dopamine in the brain to control symptoms. Carbidopa prevents the breakdown of levodopa before it reaches the brain, reducing side effects like nausea. It's crucial to manage "wearing off," where symptoms return as the medication's effect diminishes, and distinguish between "on" time (when symptoms are controlled) and "off" time.
Over time, individuals may need more carbidopa-levodopa as Parkinson's progresses, reflecting the disease's changes rather than the medication's failure. However, carbidopa-levodopa primarily treats motor symptoms like slowness and stiffness, not non-motor symptoms such as fatigue or cognitive difficulties. The perception of reduced effectiveness may arise when new, unresponsive symptoms develop.
Carbidopa-levodopa may alleviate tremors in many cases, but its efficacy varies. Specialists often prioritize addressing symptoms causing disability, such as slowness and stiffness. Side effects can include orthostatic hypotension, dyskinesia (involuntary movements), and various gastrointestinal issues.
Dopamine agonists like pramipexole mimic dopamine effects without converting into dopamine, providing longer-lasting relief. While not as effective as levodopa, they can complement its effects. Side effects may include hallucinations and compulsive behaviors.
Monoamine oxidase B (MAO-B) inhibitors, like selegiline and rasagiline, increase dopamine availability by inhibiting its breakdown. They can be used alone or with other drugs and may help prevent wearing off. Side effects include headaches and increased hallucination risk.
Catechol O-methyltransferase (COMT) inhibitors, like entacapone, extend levodopa's effects by preventing its deactivation. They are effective in combination with levodopa but may increase dyskinesia risk.
Anticholinergics and amantadine, while used in the past, have limited benefits due to side effects. Anticholinergics may worsen certain symptoms and are not commonly prescribed for Parkinson's. Amantadine, however, can improve slow movements and rigidity, especially in the early stages.
Adenosine receptor antagonists (A2A receptor antagonists) like istradefylline may reduce "off" time without worsening dyskinesia, providing an alternative approach to symptom management.
In conclusion, managing Parkinson's involves a range of medications targeting different aspects of the disease. Each medication has unique benefits and potential side effects, and their effectiveness may vary between individuals. Regular communication with healthcare teams is crucial to adjust doses, address side effects, and optimize symptom control throughout the disease's progression.
This video addresses following questions:
पार्किंसन रोग कैसे होता है?
पार्किंसन रोग का मुख्य कारण क्या है?
पार्किंसन रोग का इलाज क्या है?
पार्किंसन को हिंदी में क्या कहते हैं?
पार्किंसंस रोग के लिए सबसे अच्छी दवा क्या है?
क्या पार्किंसन रोग का इलाज संभव है?
लेवोडोपा का उपयोग पार्किंसंस में किस लिए किया जाता है?
पार्किंसन रोधी दवाएं किसके लिए उपयोग की जाती हैं?
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