This Annihilation seems easy due absence of Sarkaz Wither Tank, Londinium Mobile Defense Artillery and "The Last Steam Knight" . Although still need watch out for the Sarkaz Devoured/Maw and Rot Eater.
note for those of us who don't like leaking: you can use S3 Y'alter to spin the bottom lane 3-4 times (depends on level/mastery) to clear them out early
Lol I accidentally brought Typhon S3 instead of S2 and the run was still fine. Typhon just auto attacked the entire stage. Fia (S3M3 no mod) and Thorns S3M3 are pretty much enough to carry the entire anni.