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【The Key Point explained】Cell Cycle-Specific? Anticancer Drugs【Anti-Cancer Drug Pharmacology】 

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Join Dr. Chat Perche, MD, PhD, for a high-speed study session.
This video is designed so that by the time you finish watching, you'll have perfectly memorized the frequently asked exam topics.
By the end of this video, you'll have perfectly memorized about Cell cycle and Anti-cancer drugs.
Unlocking the points of cancer chemotherapy and the cell cycle!🧬
In this video, I'll guide you through understanding how anti-cancer drugs work with the cell cycle. It's not as complex as it seems - join me as I simplify the process and make it easy to remember. #cellcycle #pharmacologylectures #cancertreatment
【Notes】
▹This video was created based on data as of January 2024, with the purpose of supporting medical students in their exam preparations.
▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited.
【Contents】
00:00 The basics of chemotherapy
00:57 cancer drugs works with the cell cycle
01:03 antimetabolites: mechanisms of action
01:56 topoisomerase inhibitor: mechanisms of action
02:44 plant alkaloids; mechanisms of action
03:21 alkylating agents: mechanisms of action
04:03 anti-tumor antibiotics: mechanisms of action
04:37 cell cycle specific vs. non-specific anticancer drugs
【Reference and figure】I express my gratitude and respect for your wonderful achievements.
1. Judith A. Smith, Anuja Jhingran, 28 - Principles of radiation therapy and chemotherapy in gynecologic cancer: Basic Principles, Uses, and Complications,
Editor(s): David M. Gershenson, Gretchen M. Lentz, Fidel A. Valea, Roger A. Lobo,
Comprehensive Gynecology (Eighth Edition), Elsevier, 2022, Pages 618-636.e1,
ISBN 9780323653992,
doi.org/10.1016/B978-0-323-65....
(www.sciencedirect.com/science...)
2. Benjamin Izar, David P. Ryan, Bruce A. Chabner, Chapter 9 - Principles of Chemotherapy,
Editor(s): Leonard L. Gunderson, Joel E. Tepper, Clinical Radiation Oncology (Fourth Edition), Elsevier, 2016, Pages 171-185.e2,
ISBN 9780323240987,
doi.org/10.1016/B978-0-323-24....
(www.sciencedirect.com/science...)
3. Carmen Avendaño, J. Carlos Menéndez, Chapter 2 - Antimetabolites, Editor(s): Carmen Avendaño, J. Carlos Menéndez, Medicinal Chemistry of Anticancer Drugs, Elsevier, 2008, Pages 9-52,
ISBN 9780444528247,
doi.org/10.1016/B978-0-444-52....
(www.sciencedirect.com/science...)
4. Pommier Y. Topoisomerase I inhibitors: camptothecins and beyond. Nat Rev Cancer. 2006 Oct;6(10):789-802.
doi: 10.1038/nrc1977. PMID: 16990856.
5. Lee JH, Berger JM. Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II. Genes. 2019; 10(11):859. doi.org/10.3390/genes10110859
6. Galal H. Elgemeie, Reham A. Mohamed-Ezzat, Chapter 8 - Anticancer alkylating agents, Editor(s): Galal H. Elgemeie, Reham A. Mohamed-Ezzat, New Strategies Targeting Cancer Metabolism, Elsevier, 2022, Pages 393-505,
ISBN 9780128217832,
doi.org/10.1016/B978-0-12-821....
(www.sciencedirect.com/science...)
7. Kelland L. The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer. 2007 Aug;7(8):573-84. doi: 10.1038/nrc2167. Epub 2007 Jul 12. PMID: 17625587.
8. Han, D., Serra, R., Gorelick, N. et al. Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor. Sci Rep 9, 17936 (2019). doi.org/10.1038/s41598-019-54...
9. Alberts, B. DNA replication and recombination. Nature 421, 431-435 (2003). doi.org/10.1038/nature01407
10. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Alkylating Agents. [Updated 2015 Mar 10]. Available from: www.ncbi.nlm.nih.gov/books/NB...
11. Bhattacharya, B. and Mukherjee, S. (2015) Cancer Therapy Using Antibiotics. Journal of Cancer Therapy, 6, 849-858. doi: 10.4236/jct.2015.610093.
12. Abe K, Ikeda M, Ide T, Tadokoro T, Miyamoto HD, Furusawa S, Tsutsui Y, Miyake R, Ishimaru K, Watanabe M, Matsushima S, Koumura T, Yamada KI, Imai H, Tsutsui H. Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis. Sci Signal. 2022 Nov;15(758): eabn8017. doi: 10.1126/scisignal.abn 8017. Epub 2022 Nov 1. PMID: 36318618.

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8 июл 2024

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Комментарии : 2   
@StudyMedwithDr.chatMD.Phd3210
@StudyMedwithDr.chatMD.Phd3210 5 месяцев назад
I hope you achieve outstanding results on your exam! Best of luck!😊
@StudyMedwithDr.chatMD.Phd3210
@StudyMedwithDr.chatMD.Phd3210 5 месяцев назад
By following the order of DNA synthesis, understanding cell-cycle specific agents becomes more manageable😊
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