Amazing video and project. You are the best anti-aging communicator out there! I wonder what biological age you would get if you change ALL the biomarkers to the expected population values?
For hsCRP another candidate is: Metabolic factors and high-sensitivity C-reactive protein: the HUNT study 2011, Laugsand et al. This paper splits into metabolic risk categories, which is sensible given your diligence here.
@@conqueragingordietrying123 Another couple of papers are: -Sex and age differences in the association between high sensitivity C-Reactive Protein and all-cause mortality: A 12-year prospective cohort study, 2023. Sadly this one is paywalled, but I believe it has a nice plot vs age. -Socioeconomic status and C-reactive protein levels in the US population: NHANES IV, 2005, Alley et al. This one has a plot with a fraction higher than a certain value vs age, and has an interesting odds ratio analysis.
Michael, you said you decreased your fat intake to improve your glucose levels. How did you replace those fat calories? Complex carbs? Protein? Great video, thanks for sharing!
Excellent and informative analysis. Thank you, Michael! Keep on! I'm always puzzled about the inclusion of calendar age in Levene's BA calculation. The calculator is highly (overly) dependent on calendar age. For example, if you keep the same biomarkers that you reported here but change your age to 35 it will say your BA is 20.93. If you keep the same biomarkers and enter 70 as your age, your BA comes up as 51.63. So, if someone manages to keep their biomarkers constant over time, the calculator still says you got older. I'm sure you are aware of this behavior of the calculator. I think a better way to do this is to remove the calendar age input. Thus, a better calculator would just be one that determines the total biomarker deviation from optimal values and calculates a "total biomarker score" with a reporting on a scale from 1-100.
Hi Phil, yep, a maximal PhenoAge reduction is ~20y, even with the most youthful biomarkers at older chronological ages. Chronological age on its own is associated with an increased all-cause mortality risk, but the inclusion of the biomarkers improves upon only including CA as a predictive tool for risk of death. Outside of biological age clocks, I think tracking individual biomarkers, as shown in the video, is a good approach, too.
For RDW I think you are aware of the other candidate: Effect of age and gender on reference intervals of red blood cell distribution width (RDW) and mean red cell volume (MCV), 2015, Hoffmann. Much larger N, but wide age categories. Its hard to find plots with individual points these days with stronger ethics standards.
This is great, thanks @espinosalexis. I don't want to pick on Paul (again) in a video, so I'll likely reach out to him directly, to see if he'd be open to a collab
Yikes, my RDW was 18.1, but it went way down after I resolved my anemia. If someone is similar then if you're due for a colonoscopy also get an endoscopy at the same time. Mine was caused by long-term bleeding from hemorrhoids and possibly from ulcer (per the endoscopy and I went on antibiotics).
On the lymphocyte % plot, looks like some outliers are there, probably silent infections. Whether they are from low lymphocytes or immune cells need further digging because of the percentage ratio.
@@abdelilahbenahmed4350 I'm not sure what your referring to, but you'll probably see it revert to baseline next time as Mike usually only makes small changes test to test.
Great insight as usual 👍 in 2015 your biological age was already 6years younger than your actual age, 42 chronological 36 biological, how was your lifestyle before you started testing frequently? were you living a similar healthy lifestyle or it's because of good genetics?
Generally healthy, but without the guidance that I have now from following correlations with diet That plus a ~20lb weight loss have helped improve most biomarkers I don't have good genetics-prior to my dad (still alive at 81y), all men were dead before 67y, no women > 100y
My most recent blood tests. I don't track my food. The improvement is purely from drugs and supplements (+ some luck). Calendar Age 45.78 45.82 45.87 Ptypic Age 30.57 30.21 28.73 Calendar Age - Ptypic Age 15.22 15.61 17.13
Such an informative video! What, other than normal aging, could cause a drop in serum albumin? Could overtraining before a blood test cause a temporary dip? Could iron deficiency cause it? You are right about not sweating a change on one blood test! It is stressful.
Thanks @jpintero6330. Maintenance of albumin levels involves synthesis vs degradation. The latter can be impacted by inflammation... In terms of overtraining, it's an easy experiment to test-if you rest for a day or 2 before blood testing, is albumin the same, or higher? For me, and prior to every test, the day prior is as close-to a rest day as possible.
mcv ( lower better ) and urea ( lower better ) and bmi ( lower better ) and albumin ( higher better ) and especially ferretin ( lower better ) read this week in some report is most predictive of biological age .
I noticed that my glucose reading is heavily impacted by the time and the amount of my last meal. The lab asks for 12 hours fasting, but if I skip the dinner on the night before, or eat a little, my glucose can be 10 points lower. If I ate a lot, even 12 hours before, it affects it. Also, if I do my morning exercise before the test, it messes with it, too. So, to get a meaningful data sequence from glucose, it takes a lot of consistency. Alternatively, I can wear CGM and take the averages after sleep, for example.
Yep, that's a good point. before every test I've standardized the fasting window (16-18h), with minimal activity (close-to a full rest day) on the day before each test. I also eat close to the same diet on the day prior, too, to try to standardize that, too.
You shouldn't exercise before a blood test if you are interested in a fasted and rested state. It will change many of the biomarkers. It sounds like you have a slow GI passage time, so you'll need to be consistent with meals to get repeatable glucose values.
I'd like to know if your parents are roaming the Earth and their overall health. Also, do you have health and longevity in your DNA from your grandparents? I guess you are the lab test guy for the longevity trial you are running---but it would be interesting to me to know if you already have a family lineage with long and robust health. Thanks.
Hi Paul, my dad is 81 and in decent shape, and myy mom is 77. Before that, no men in my family lived past 67y, and my grandmothers lived to 86 and 85y. One reason for my passion in this field is that I don't have longevity genetics, and I'll need to science the **it out of aging to break the human longevity record!
Wow, now I’m wondering if the males in your family smoked or drank. Bothe my grandmothers lived to be 94 but not that I’ve done the 23andMe test it freaked my world out when I found out my dads mother couldn’t have been his biological mother and my fathers maybe father died at 42 from colon cancer. I guess my dad was adopted and never knew cause he thought he was German and that was 100% wrong. But, my dad died at 62 from cigarettes and my Irish grandfather was an alcoholic who managed to live until 72 but he was a mess for 10 years before his death of heart disease. Did you ever have your DNA tested? It can be very upsetting if you your results opens a five gallon can of worms and with not many clues to follow.
Yep-LabCorp can measure below 0.3 mg/L, but I'd have to drive 17-20 miles to go there With that in mind, I'm ok with Quest's detection limit (< 0.3 mg/L)
@@conqueragingordietrying123 I would agree with that, with correlations becoming less useful with lots of measurements below the threshold. Maybe ESR is worth doing instead.
Hi @justsaying7065, yep-I cut strawberry intake to bring oranges (proline betaine) into the diet. Oranges didn't mix well with the yogurt, so I took it out and replaced those calories with chickpeas and sprouts...
@@conqueragingordietrying123 I was thinking exactly the same thing... that it may be one of the key variables. Men's average glucose there is equivalent to a woman's almost 12-15 years older.
What kind of fat and how mich did you take at the beginning? Im more or less on a high fat diet: 80-115g of fat, mostly by nuts and olive oil and some fat fish.
Mostly SFA via coconut butter. I'm working my way back up (from 81 - 95g/d), but this time increasing MUFA while keeping SFA from coconut butter relatively low.
If you want a test of your biological age with no input of your chronological age, you can take OMICage from Trudiagnostic, but it's 10 times more expensive than this test. But it is likely a lot more precise. Levine's test gives me 8-9 years lower age, OMIC gives me my age.
@@maestroharmony343 I have. It’s a completely different methodology, blood test markers versus DNA methylation. I asked the question because if the calculation of Levines phenotypic age requires chronological age as an input as a biological age adjusted measure, that artificially skews the results
@jonathonmills3563 it would be hard for such a small set of markers, only 9, to accurately predict your age with no hint of your real age. As I understand, about 88% of this calculated phenotypic age is explained by your calendar age, but the rest 12% depend on the biomarkers. So, it is not completely useless.
@@maestroharmony343 The Pheno age calculation is useful as is modifying the components, as Dr Lustgarten does. My argument is that Dr Levine accurately refers to it as PhenoAge , not Biological age. Dr Lustgarten should make that distinction
Creatinine datapoint in Levine's estimator is a suboptimal choice. I eat a lot of meat, and my Creatinine is high, which is translated into a low eGFR, but when I measured Cystatin C, it was very good, and eGFR based on it was perfect. Unfortunately, it's a lot more expensive test.
I don't disagree, but the good news is that creatinine contributes relatively little to the PhenoAge score relative to other biomarkers (i.e. RDW). What was your Cystatin C level?
@jamesgilmore8192 I don't bodybuild, I sit a lot at work, so I mostly try to walk and hike when I can. I also do some exercises in the morning to break the sweat. I supplement with 5 g of creatine though.
Hi, I see you are always in a calorie deficit, but do you also want to build muscle or just maintain it? Have you seen that you can build muscle even in a deficit?
The goal is to be as lean as possible with enough muscle mass to be strong and fit, in combination with optimal biomarkers There's a recent pic on the Community tab...
Yep-I can't say if it's causative, but the strongest correlations in my data are for calorie intake (0.71) and body weight (0.62). So getting leaner over the past 3y might've lowered it...
That's tricky, imo At those ages, I think the best approach is to ensure at least the RDA in terms of dietary intake-I wouldn't do all the blood testing that young Once they're older (> 18y), they can choose for themselves if they want to test, and how often
4:35: An RDW of 11.7% would be more likely to be found in youth? Sorry, but I can barely see any circle below 12% for people below 70, but many for older than 70.
Pheno age is based on nhanes, see: Red blood cell distribution width and mortality risk in a community-based prospective cohort: NHANES III. RDW Quintile 1, mean age 39 has a range 10.90-12.35. Whereas the figure is from an Italian study. The difference is probably from different analysers.
@@conqueragingordietrying123 I merely commented on that particular other statement about the 11.7%. The dots/circles in your own chart disagree with 11.7% more likely being found in youth because only people older than 70 had such low values.
Hi again :) Ok, im really into tracking so im doing this xcell spread sheet and I have some questions... I'm not seeing ...Where does it calculate your biological age?? can you please tell us more about row 16 please and thank you :)
Hi @HopeItStixStudios, I can't say what may work for you, but Omega-3 intake and weight loss may play a role: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-cOg91UU6NNY.html
Did you take a real blood test for RDW or read Trudiagnostic estimation in OMICmAge? Because they are off a lot usually, since they don't measure it directly.
@HopeItStixStudios they only do the prediction of it based on epigenetic data. I talked to them directly, they told me not to pay attention to those numbers (blood marker equivalents), they even think to remove them altogether since they may be confusing more than useful. But the percentile number is important.
