Wikipedia says "Phren, however, is not exclusively applied to humans. In Empedocles' system, Phren is a general psychological agent to which moral blame and praise can be extended, that darts through the universe as effluences, steers and controls the cosmos in the process and is the measure of what is harmonious and what is fit to exist. It is said that it is strongest at the region found beyond the universe where strife reigns."
