Yea but i have seen it in 243- 22 250- 338 win mag also the 22-250 between winchester large rifle shooting 1/4" 100 yd groups . Now the exact same load with cci bench rest primers shot 6" left of point of aim and group was 3" . Thats why when working up loads if i have trouble getting a tight group then i will try same load but different primers and i can always seem to find a happy group.