25. Cancer 1 

He is a great explainer... Thanks MIT for sharing this... Worth watching..

Great stuff!! Keep up on sharing knowledge to the world guys!! May god repay your kindness ❤️

(On Wednesday of February 8, 2023). Cancer (Neoplasia or Proliferation Disease State) is a Pathologic Growth of Tissue (Neural, Muscle, Epithelial, or Connective Tissue): 1) Dysregulation and Degeneration of Normal Tissue Growth (Normoplasia or Euplasia); 2) Genetic Molecular Mechanism of Gene variation or Pathologic Changes within the Genome; a) Oncogene (Proto-Oncogene Transformation) is a Pathologic Growth Signaling Gene expression, usually a Transcription Factor of Growth; b) Proto-Oncogene is Beneficial and when Normal promotes Cell Survival (Growth and Proliferation); c) Loss of Regulated Proto-oncogenic Function (CDKs, E2F, Wnt, MYC Gene Variation et al) is a Possible Mechanism of Neoplasia, also known as a Gain of Function (GOF) mutation (Accelerated growth or Loss of breaks analogy); d) Tumor Suppressor Genes (TSGs) are marked by a Loss of Function Variation of a Gene (Mutation otherwise), usually a TF (p53, BRCA1,2 etcetera); e) TSGs are known also for Regulatory Function of Cell Repair (DNA Repairing) and integrity of a Cell. Caretaker or Custodians of the Genome are other epithets, f) Growth Signals (Growth Factors [GFs]) regulate Gene expression of Cyclins (G1 Cyclin Specifically to G1-S Cyclin [Commitment to Cell Cycle Signal]) and Other Cytokines (Il-6, TNFs) can be Signal of START; g) E2F (TF) where RB Protein Bind to such represses (mRNA biosynthesis of E2F) where the Phosphorylation of RB (Retinoblastoma Gene; First Cloned Gene) deactivates Such and E2F is capable to Bind the Promoter Region of DNA Molecule (Biosynthesis of mRNA or Transcription will ensue); h) RB Gene Variation (Mutation) can have Neoplastic Growth Processes leading to Neoplasm therein: 1) In Sporadic Variation, there is no History or Diathesis of Neoplasia specifically within the Retina and usually manifests unilaterally (affecting only one Eye); b) 2) Familial RB (Diathesis) is an Inherited and pathologic Variation of RB Gene (Bilaterally manifestation) and implies predisposition to this Proliferation Disease. The Inheritance pattern is Autosomal Dominant (AD) involving equally Female and Males and involves all generations therein (no Generational Latency as in Recessive Inheritance) phenotypically. However, the actual Process is Autosomal Recessive (AR) with a Predisposition (Somatic Transformation of Homozygous Significance i.e. Phenotype Post-Gametogenesis Manifestation [Retinoblastoma Neoplasm]); a) Point Mutations, b) Chromosome Loss, c) Deletion, d) Gene Repression. In Colon Cancer and Famlial Adenomatous Polyposis (FAP): 1) Dysregulate in the Wnt Signaling in the Stem Cell Niche Process; 2) Neoplasia Pathogenesis: a) Mutation of Euplastic Tissue; b) Dysplasia; c) In Situe Neoplasia (Anaplasia); And d) Francoanaplasia (Metastatic and Invasive Neoplasia); 2) Adenopolyposis Colon (APC) Gene Aberrance; a) Wnt Signaling Constituively activation; b) Further Genetic variation Inducement;......Translocation of Philadelphia Chromosome (9,22 Transformation) in CML in the Abelson Protein And Gene. (Proto-Oncogene) PhD Adam Martin, Es geht gut und nicht vergessen niemal Gesundheit werden haben warum Gesundheit geben. Heil!

Excellent explanation!

Thank you sooooooooo much for those great lessons!!!!!

So interesting love it!

It's a great class

Very good

tbh ngl, im enjoying watching these,even tho I'm still grade 11

Are there family inheritance trees out there where heterozygous individuals are marked as well (if known)?

mere kajan ko cancers ki problam ho agi se usne bhut se doctor seelaj krwya koi frk nhi pda fer osne planet ayuveda se apna treatment krwya or oski cancers problam thik ho gai .

Chalk? What about PP slides?

Hey all, Does anyone have any lecture notes on this lecture by any chance? Thanks :)

What pathogen is causing the mutation…

this is my asmr lol i fell asleep at s

What’s with the close up’s on the lecturer?

😅Detailed lecture assimilated thanks

Aneuploid.... chromosome extr??only one..?..genetic integrity caretaker genes.....

If it has defective brakes and it keeps on dividing uncontrollably it would grow to an enormous size. A fertilized egg becomes a 8ob baby in just nine months. So unregulated / uncontrolled cell growth would be at least his in a year. That is not what we see.

I lov cancer ♋

I’m not sure making science the Oscars is a good idea. I mean have you seen how scary that event has become? 😹 Thanks for another lecture about the beautiful function of our bodies.