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Gas bubbles within the circulation can obstruct vascular flow (and cause distal ischemic injury) almost as readily as thrombotic masses can. Air may enter the circulation during obstetric procedures or as a consequence of chest wall injury. Generally, more than 100 mL of air are required to produce a clinical effect; bubbles can coalesce to form frothy masses sufficiently large to occlude major vessels.
Kumar, Vinay, Abul K. Abbas, and Jon C. Aster. Robbins basic pathology e-book. Elsevier Health Sciences, 2017. Kumar, Vinay, et al. Robbins and Cotran pathologic basis of disease, professional edition e-book. Elsevier health sciences, 2014. www.amazon.com... www.amazon.com...