A Doctor's Guide to AUTOPHAGY and FASTING: Lose weight, reduce inflammation, and live longer! 

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I work as a hospitalist. I don’t eat breakfast or lunch and eat a " dirty keto " supper. I lift weights. I walk 3 miles from 4: 30 AM to 5:30 AM. Study medicine and drink coffee from 5:30 to 6:30 AM. Start work at 7:00 AM every other week. I lost 40 pounds and have maintained it for 7 years. My CRP is undetectable and cholesterol excellent. My mind is sharp and clear. Autophagy and coffee work for me! I cheat only on holidays for family acceptance. Keep up the good work. Love your site!

My husband gets so upset that I choose to do 20/4 - I fast from 8pm until 4pm every day unless something comes up. And I work around it but my husband gets upset for i skip meals. He feels the most important meal is breakfast which I don’t eat any more. I have dropped 25lbs and I am able to maintain my weight of 125lbs and I am 5’6” so this is so exciting! I’m now a small in most of my clothing. It really has changed my life.

Day 35 no sugar, I've never felt this good in my life. 41 yrs later starting intermittent fasting. Thank you💯

I started IF in July and have lost 30 lbs! This is a game changer for me...I recently did a 42 hour fast to boost my autophagy. Thankyou for this information putting it in plain, simple terms! I am no longer pre-diabetic, my thyroid is back in normal range, my joints don't hurt anymore and my plantar fasciitis went away! Game changer!!!

This video deserves an Oscar! AND a Pulitzer Prize for explanatory reporting.

My doctor laughs at me when I bring up fasting and keto. But he is very impressed with my washboard stomach muscle. I’m age sixty 169lbs, 5 years ago I had joint pain, pre diabetic and 200 lbs. I only see my once a year for blood work, and the numbers are good. Most people recommend talking to your doctor, however most of them don’t understand nutrition or tell to eat Three meals a day and reduce fat and eat grains. Food pyramid needs to be changed, the food conglomerates control the government along with the drug companies.

I don't do fasting to lose weight. For almost 3 years I've been battling a myriad of medical issues. I had learned about and been doing IF for several years. Changed my eating. No processed foods. Reduced sugar immensely. I do fasting strictly for medical reasons. I honestly believe it is the only reason I am alive.

I have been on a intermittent fasting journey for around 9 months now. I use the 18/6 method and I have lost 64 lbs. But the real bonus for me has been Autophagy. Every 4-5 weeks I will go on a water fast. The first time was for 72hrs. Then I did it again for 96hrs. The benefit of mental clarity is eye opening. But the benefit I noticed mostly is that the pain I used to experience in both my knees has become so much more manageable. No pain killers. Just letting nature do what our bodies are made to do. I do on occasion get sore knees again. But not anywhere near as bad as they were. I also walk a great deal. Anywhere between 6-10 miles a day. Most days it around 7 miles in under 2 hours and these days that is done with comparative ease. I cannot recommend strongly enough the real benefits of Autophagy. And I certainly feel that Doctors and more health practitioners should be doing more to promote this. Especially if you are overweight or someone with constant symptoms causing you pain. You have absolutely nothing to lose, and everything to gain by trying this.

I’ve been doing this for years as I have SLE. I am American Indian and use native herbs, roots, etc. I was experiencing liver issues. When I get a flare, I fast throughout the flare. It has helped me tremendously. I recently, had severe CoVID and autophagy was helpful.

I just completed a 84 hour fast. This is a great video describing why I feel so good. The scale didn’t change an ounce. But that’s not why I did it. It was all for my cells. Thanks for all your common sense, simple descriptions. Make’s understanding the harder processes very simple✌🏼

I wanna do whatever she is doing. She is gorgeous! I'm always surprised by the amount of doctors who look like they could drop dead at any moment while they lecture you about your health

Thank you for the informative video. I have just started intermittent fasting (18 hours now). It's good to know how amazing our body is to heal itself. I'm looking forward to more videos.

Thank you so much Dr. Rajsree for your information it’s very educational. I started intermittent fasting about a month ago I’m doing 20/4 and a couple of 24 hours of fasting. I’ve been trying to lose about 40 pounds for the last couple years and nothing worked for me until I started doing intermittent fasting. I dropped 8 pounds already I never thought I could do it but I’m more motivated now than ever.

The most amazing and outstanding information and explanation I have ever seen I'm insulin resistance and I started keto and intermittent fasting mid February I'm down to 35 pounds and doing great..thanks to the all doctors on RU-vid informing us

Greetings from an American expatriate in Taipei, Taiwan! I listened to this during my daily one hour walk and I have also shared it. I’m about to listen to it again. Super informative! Thank you

I have seen many RU-vid videos on autophagy, but this one is one of the easiest to grasp and well presented! I practice intermittent fasting myself (6 days a week of 16/8 and one day of 24 hr fast). I have seen many of the benefits described here, including weight loss (BMI of 31 down to 24.5 in 2 years) and complete reversal of Type 2 diabetes within 6 months. A switch to a completely plant based diet also helped. These strategies are well worth following, and as mentioned in the video, fasting is essentially free!

Subscribed to add another intelligent person to my Arsenal of healing. I have gone from 340 to 240 in exactly one year. I do 16 hour fasts every day, basically my normal eating schedule now and a 24 hour once a week. I’ve implemented 72 hr once every 2 months. My triglycerides have gone from 300 to 99 and fasting insulin 125 to 95 I feel better but I have a 40 lbs to go. Keep up the great work and thank you for the life saving information. Everyone listen to this intelligent Dr. it’ll save your life!

Thank you for this. The majority of videos I've seen and articles I've read were about fasting affects in general. The part where you applied it to women specifically is much appreciated!

I can tell that you care about your patients and you love what you do. Your videos are thorough and have given me much clarity on how to better take care of my health 🙏🏾

Thank you for your video. This is the most thorough discussion on autophagy I have yet seen on YT. This has helped me a lot.

This video was quite impressive. Not only did it provide some incredible information it did so in an entertaining way. Thanks for sharing.

Excellent video that gives a concise but well explained summary of autophagy and fasting. Can’t wait to share this one with my wife. I am about to turn 46 in another week and I have been doing something different this year. Through a combination of getting back into the gym for 60 minute workouts three times a week, better eating habits which include an 80% reduction in processed foods, and a healthy balance of intermittent and longer-term fasting (my longest so far is 40 hours but I hope to improve that to 72 and beyond) I have so far reduced my weight from 205 to 188 and more importantly I feel better, I think Sharper, and I’m not dreading 46 like I once was. I’ve replaced numerous pounds of fat with muscle growth! I’m now on a quest to be healthier and more physically fit at 50 than I was at 30.

I am a retired teacher and I loved this presentation! I have taught health as well and I think this could be shown to high school students. I believe we need to teach our students MORE about how to live a healthier and happier lifestyle. I would certainly want them to know how to meditate and how to combat metabolic syndrome, diabetes and all of the benefits mentioned in this video. My goal as a teacher was to help students be successful with the stress on happiness more than any money. I want my PCP to be in integrative medicine and though I live near Seattle, they seem to be few are far between. Any ideas?

Those dislikes are probably from people that can't even stay away from food for more than 10 minutes 🤯😂 This video was so clearly explained, I'm glad I found you dr!

Wow I’ve been doing keto more than a year now but didn’t know about mtor. Thank you Doc. I’m happy I’ve found this channel

Everyone who attended high school biology classes has memorized "mitochondria is the powerhouse of the cell". :)

Dear doctor Rasjree Nambudripad, thanks for your scientific and concise explanation on Autophagy. The balance between excercise and rest is so important to elderly people like me. Again thanks for your superb contribution to our - my health.

This is the best video I've seen on the subject of autophagy. I've been familiar with these benefits at least 25 years before the name autophagy came on the scene. This good doctor fills in a few of the blanks everybody could benefit from. Especially the relationship between Mtor and autophagy. Thank you doctor.

Thanks for the simplified explanation on autophagy. I have been doing intermittent fasting for the last one year. It is good for the whole body.

Excellent video! This is what I want to bring to my physician. Getting back on track. You put it together well Dr. Rajsree, Thank You.

An excellent and comprehensive overview of intermittent fasting and autophagy -- well suited for beginners as well as more experienced viewers.

Finally! A simple explanation to autophagy anyone can understand.

Nicely done. I'm 58 and a 7-year vegan that eats once a day between 4:30-6:pm with 20-hours of fasting...” daily”. And it feels amazing! My blood test says it all. No more IBS, kidney stones, bloating, and my acute pancreatic pain went away. My motto is, very, very little sodium, avoid the nightshades, caffeine, get sugars from the plants and low sugary fruits, avoid GMO's, alcohol, eat mostly anti-inflammatory foods, and eat processed plant-based meat-less products sparingly. ✨🖖✨

Thank you doctor Rajsree, very good information! Also, is the first time I see a doctor replying to messages. Well done, I highly appreciated.

The clearest and most informative podcast on inflammation on the internet. Thank you.

Amazing!!! Again another gem 💎 video. It’s unbelievable, how dr. made it so simple and easy to understand to everyone with even who do not have a medical background. God bless you for covering so so so important topic.

Thank you, Dr. Nambudripad, for a clear, thorough review of autophagy and its benefits. There is a lot of dubious, melodramatic information about health posted on RU-vid. Your video was like a breath of fresh air. I wish that more RU-vidrs would adopt your clear, well-organized approach to discussing health-related topics.

Dr Rajsree has the TALENT to explain difficult topics in an easy and enjoyable way so that even a fifth grader can understand.. God Bless you and please continue your work at least forever!

This video from Dr. Rajsree is the best place to explain Autophagy so completely and easy to understand. Thank you, doctor!

Thank you, Dr. Rajsree for sharing this wonderful health information. I hope many will benefit from your educational, cutting-edge, healthcare videos.

Thank you for this life saving information at a fourth grade level of comprehension. Now we can reach the masses!!!!!! God bless You Doc!

Thank you so much for this informative video. I am 3 days into Keto. I started right away fasting. So everyday so far I have fasted for 17 to 18 hours. I rarely feel hungry. I am going to work my IF to 20 hrs. and then progress to 72 hours.. I know it will make me feel better!

The best video to introduce autophagy to people and trigger their interest to take action. Also the first video I saw that I feel confident to share with my wife because it's clear, comprehensive and includes a special section for women. Next would be to learn more about fasting safely as a starting vegan. 😊

Thank you for this video and all the other videos you have created. So simple and easy to understand. My husband and I are so glad to have you care for us. Truly enjoy watching all the videos and information you provide.

I just really appreciate any non-chemical medical advice. I know you are doctors of medicine, but geez, this right here is the most important thing to know with medicine being used hopefully for acute issues with the body. Thank you so much!

With respect, your videos were always good, but the new explainer style really whacks it out of the park. Simple, easy to relate to and understand, and not too detailed or lengthy. Keep them coming. Excellent!

Very informative very eloquent clear description on what's going on with your body and ways to heal your body. with the benefits of intermittent fasting. Thank you💕 for many years inadvertently I may have been doing this in my working day each day. I used to take my beautiful Daughter to school she used to like me taking her and picking her up from school. I was self-employed and I thought I can do this. I used to drop her off at 8.30 and pick her up at 3 p.m. from when she was little First School right up until she was 16, from school, (from when we she was 15/16 sometimes she walked home, but I always make sure to be home to greet her) this gave me 5.5 hours work straight through with no lunch breaks then get her evening dinner ready so that meant I hadn't eaten from 5 p.m. to 5 p.m. my job was very hard physically outdoors I just used to run on filtered black coffee in a flask all I had all day was just one small square 1 inch by 1 inch what I called an energy cake I made which consisted of wholegrain self-raising flour one complete orange and lemon with peel with some cane sugar blended and baked. I had to have something because once I nearly fell over where I went a bit wobbly. I used to sometimes feel like I was revving like a racing engine but I gained working time by not having lunch breaks and working straight through. I noticed I felt extremely fit and I had good muscle definition. I became very attached you could almost say addicted to filtered coffee. Extremely sadly, emotionally very hard to deal with my beautiful Daughter took her own life - non deliberate suicide-- at 16yr 2 months old with taking a massive overdose of her prescribed medicine. In Remembrance of her I still drink filtered coffee every day it reminds me of the good times my beautiful Daughter and I had together I used to take her to work with me it was safe we were in the middle of nowhere or Fields was sometimes people's gardens. I visit her garden every day, I have difficulty saying grave I call it her garden. I go to see her everyday without fail it has been 8 years 5 months 1 week 5 days. I lght 2 candles on her garden in small lanterns so the wind don't blow then out, although I can tell the way the wind is blowing through the trees there probably won't keep a light some days but I try anyway. The kindly doctor you came out to me, a day later I think after my Daughter went away. I was really really traumatised crying, beyond words what feels like. He was really good words and advice, he said when you're ready go to work, work is good, do whatever it is you need to do each day keep busy. I understood what he meant take your mind off things, not to think. Very often there was no one there I used to be crying at work every day. 1-year ago One day I know it's my heart was like missing a beat or the next one would be a very big beat. Concerned I went to the doctor's when they wired me up my heart was good my blood pressure was I though 167/ 85 when I mentioned The coffee thing I got up to 2 L A Day they stopped writing and said that that wouldn't help your BP. I completely stopped it's now 119 / 69 I have started drinking the coffee again but no more three quarters of a litre / 1 pint I have not come to terms with my daughter going I've just learnt to live each day💕💕 I apologise if this is too long comment but seem to help writing

I will be 66 on March 4th this year. I began my journey of intermittent fasting with an aggressive carb and sugar restricted diet in the latter part of June, 2021. I began just eating one good meal per day. It was much easier to do than i thought it would be. After two months of that, i lost about 60 pounds of excess fluids and body fat. I was also able to reverse almost every chronic health problem that plagued me for decades. Some of those conditions included obesity, a fatty liver, edema in my lower legs and feet which led to chronic cellulitis occurring in the lower legs. I would bruise easily, contract infections easily, and it would take a long time to heal. I was also urinating frequently at night, had occasional hypertension and had symptoms related to COPD, among other things. All of these conditions have at best, completely reversed, and at worst, have greatly improved. There are two issues that i am still struggling with. My feet are always sore, and my toes are stiff. I suspect that there may still be some stubborn neuropathy in my feet. And have also had a hard time of eliminating the puffiness under my eyes. Do you think it could be helpful if i try multi day extended fasting once in a while?

The comments section is amazingly motivating...thanks guys!!! I feel empowered to start!!!

Thx for being so clear with your explanations! It’s much easier to understand than most videos.

Dr. You are amazing! I am from Israel, 61 years old. I do an intermittent fast of 24 hours every day and once a month a fast of 48 hours, I feel wonderful. Thank you for the amazing video and the explanation that simplifies things.

Thanks for the great video! I've been doing intermittent and extended fasting for over 2 years with excellent results. I'll never return to the 3 meals a day, and I'm convinced most everyone will be doing some form of fasting in the not-too-distant future. There's so many benefits! One point I try to emphasize with those people who wonder about hunger when fasting is this: I generally eat from 9AM to 12 noon each day and my body quickly became accustomed to this pattern. I never get hungry in the evenings and feel fine most all the time.

Excellent, this theory will revelutionise the concept of health and medicine. Thank you for explaining in most advanced scientific way. We are practicing this method since 1989 after realising the efficacy of fasting for six days which removed my decades old Asthma.

Autophagy is a completely new word to me and one I have come across recently, so decided to investigate further. You video popped up and I though perfect!! You have blown my mind with such a clear concise explanation. I have suffered for years with an autoimmune condition and depression, I recently reached a crisis point and felt the only other thing I could change was my diet, skip toward 3months and I have learnt so so much about the mind body connection. This is the icing on the cake and has propelled me further with my diet and IF. Thank you so much 😊

So well done. You did this in common speak and very easy to absorb. Thank you. There are so many non medical professionals making videos on fasting. It infuriates me.

Video on "fasting mimicking diet" would be interesting, particularly its ability to actually "reverse diabetes type 2" or insulin resistance.

I’ve been fasting on and off for decades, and only got more serious about doing IF in the last couple of years. Your inclusion of autophagy is excellent, and so important for the bigger ‘health benefits’ picture. I’m passing along this great yet simple video to all I know who want: goal A, B, C… or complain about: malady A, B, C…. Rajsree, you really struck a perfect balance between providing knowledge, and making it easily digestible (pun not intended). :)

Great video! Very comprehensive and one of the best on RU-vid. Thank you so much!

Dr Rajsree is amazing. Her explanation is simple and so easy to follow. Glad to have found your podcast. SA.

I have been devouring the videos of Dr. Sten Ekberg and others. And it now appears I will be following all of your posts.Very good explanation of this important subject, congratulations

I intermittent fast 23 hours a day with a one hour window to eat and it's OMAD. I do a healthy Keto. I also try to to a 48 hour water fast once a week. And, I walk 3 miles every morning every other day. I've lost 50 lbs in the last 3 months. I don't even get hungry throughout the day.

I've been learning about diabetes, IF, etc for over a year. Your video is the clearest so far. I even learnt mTOR. Thank you for a well balanced account. KeepSmiling 😊🌺

Excellent video. My first water fast was 36 days, after which I started a keto OMAD routine. Now I am on day four of another fast. I have lost close to 50 pounds in just over two months. I have another 45 or so to go to get to what I weighed in my younger days, but at the moment I am feeling very good!

I do fast for Autophagy have been doing it about two years. The positive results at a requested eye exam lead to Dr./patient conversation. I had 3 eye improvements and I’m 75 years old, when we were done talking about fasting/Autophagy he said he’s going to do more research on, he thought it was vary interesting. I’ll just say I feel like a metabolic super power. I don’t have any prescriptions in my house. 2 days twice a month is my favorite.

wow this is an OUTSTANDING presentation on this subject....very clear! liked, subscribed and belled. Thank u!

Very comprehensive and shed light on most of the questions and confusion I had. Well done!

Very informative without the hype. Thank you.

First time watcher. I’m ver impressed with your knowledge and presentation. I also like how you respond to most of the questions. Thumbs up!

Thank you Dr Rajshree, excellent, short and well explained 👏 about Autophagy 🙏

At last! A video that explains autophagy in a way that I can understand and is useful to me. Thank you.

I'm doing intermittent fasting since more than 4 years now. I started with 16/8 then started 18/6 and then levelled up to 20/4 with 1 meal a day and doing it presently. In the initial 1 and a half years I lost 30 kgs. I'm maintaining the weight. I've gained health, I'm now as energetic as I was 20 years ago. I do fasted long walks and fasted weight training also. All fatigue is gone and now I don't feel drowsy after meals like I did. Skin is glowing, stamina has increased, immunity is much better now.

On a scale from 1 to 10 this video contents and presentation deserves a 10 plus !

I've seen quite few videos about autophagy but this one is by far the best, the use of graphics helped a lot, it is very clear, thank you so much, I will be passing this on to many other folks, I am about to check your channel, i hope to find similar videos, especially about how to deal with artery clogging. Thank you Dr., keep up with the good work.

Interesting stuff. I've been on a once-a-month 24-hour fast regimen since a fairly young age. Turns out, it's really good for your health, among other things.

I love the sound of your voice as well as the clear precise explanations of many of the body's processes

One of the best videos I have watched regarding Autophagy, Intermittent fasting and so on. I was kind of missing some more comments about what happens in the body when we eat and insuline are produced regarding fat storage and how this hormone stops the Autophagy process. It is a great compilation of all the information I have obtained about the subject from T. Delauer and Dr. Berg to mention some of the more well known resources in this field. Thank you so much for a great video which I have already shared with friends.

Great information and presentation. Thanks Doc! I deal with a lot of inflammation from years as an athlete, and now paying for such a life. I wouldn't change anything. I just want to find a way to live with less pain. I'm going after this fasting regimen! Thanks again! ❤🌹

I love 💕 everything about the video starting with the voice🤗 the visual drawings the background music and of course the information very clear and easy to follow and understand new follower alert 🚨😍

Mam - this is a very good video, explaining Autophagy in simple terms - thank you for uploading - happy, healthy, 81 year old

Thank you Dra. For a amazing, informative video. Loved it.🙏

I started fasting and my energy level improve significantly, thanks for the info.

I love you Dr.rajsree I just stumbled upon this…I’ve been intermittent fasting for a year now can’t wait to start omad!

That was awesome. The visuals were perfect: Very cute, yet to the point. Thank you creating this video.

You’re amazing. You put in so much work and dedication towards your career and helping people all around the world. You’re a class act

Thanks. That's a great video👍past week 1 - I did 24 hour IF. Week 2 - 5 day water fast and I'm currently in week 3 and day 6 of my water fast. Overall, I have lost a lot of weight, feel great, BP has gone to a healthy range, sleeping well, more energy. I'm hoping to keep this going for several weeks as I've suffered from SONK in my right knee and want to improve my chance of returning to running. Great work cheers.,

Fantastic video! Thank you for breaking the formation about auto phagy so well!

Great video, I personally do IF of 18 hours per day, 4 days a week and 2.5 days per week of extended fasting. I also do a lot of walking, routinely getting in 10k steps. It’s all come together and in the past 2.5 months, I’ve lost around 30lbs and my health and energy feel much better. I’m still morbidly obese with metabolic syndrome but I’ve made great progress so far. I know a lot of people recommend going keto, but personally I find that excessive. I do use lower carbs however.

Definitely the best explanation I have seen so far, and I have watched a lot of them

Thank you Dr. Nambudripad: Clear succinct and full of information. 👍👍👍

Thanks for clear explanation. I fast periodically and to day I ended a 38 hour fast. Low carb eater and really feel well at 74 y/o and was bad in all metabolic areas. That’s what scared me into low carb. This current fasting gave me a constant light headache but I didn’t feel hungry. Why the headache? After I had coffee and a avocado it went away, wish I had one at a time. I’m subscribing.

Wow a doctor I can really understand you made it so simple 👍 Oh and I’m a new subscriber

Thank you for your timely information. Absolutely needed it!🙏🙏

Actually deleted this and went to another video. Thoughts kicked in and came back.. so happy I did. Will give this a go and see what transpires. Thanks.

I found your videos today and have watched 2 of them so far, you have a gift of explaining medical problems, today I realized I am Kevin. I will be doing intermittent fasting starting tomorrow, fatty liver, insulin resistance, over weight, I feel terrible. This is serious stuff you speak of and I want to thank you for the wonderful advice, keep those videos coming, you are a rockstar. E.J.

Great presentation Doc. I’ve now become a firm believer in fasting. Lost 40 pounds in 5 months by kicking the carbs/sugar from my diet and adding IF (started at 16, then increased to 18-20, and do a 36 hr occasionally) and I physically feel amazing. Inflammation has gone away, blood pressure has stabilized, and best of all my mood has enhanced significantly. This lifestyle is awesome 🤙🏼

That is the best most thorough and simple explanation I’ve seen. Thank you

I knew a little about this, but this video filled in some of my knowledge gaps. Well made, accurate, and well explained.

I chance upon IF and totally change my beliefs on health and how we eat. I’m on OMAD and feeling great. No lose to energy level, hunger goes away after a week. It’s not as difficult as you think.

Excellent video. So neat and clean. Thank you!