I am thrilled to see a practitioner who is finally speaking to people with real info, knowing they can understand and use it. Thank you so much, this helps tremendously!
I am 75 years old and have been retired for 5 years. I have watched OVER 6,000 health podcasts and this is theeee best podcast. It is so clear to understand. You don't need a PHD to understand the subject matter. I am MTHFR & Apoe2 so this helped a bunch. GREAT JOB! I just subscribed to your channel and a thumbs-up.
Thank you all for watching! My Methyl B Complex for MTHFR is now available here: dr-rajsrees-public-supplement-store.myshopify.com/collections/essential-vitamins/products/methyl-b-complex Methylation Support (same as MethylCPG in the video): dr-rajsrees-public-supplement-store.myshopify.com/collections/metabolic-support/products/methylation-support Glutathione: dr-rajsrees-public-supplement-store.myshopify.com/products/glutathione?_pos=1&_sid=5c11e344f&_ss=r
I'm excited to bring this to my neurologist visit tomorrow because I've been having symptoms and problems regulating my emotions on a daily basis; my caring thoughtful and concerned great gynecologist from Stony Brook University Hospital in Stony Brook Long Island, NY to the time to do a DNA blood test back around 2008 or something. Well, I'm grateful for caring doctors like him and all doctors who take the time to properly diagnose issues then go above and beyond to really hear the patient as a human being, not just another patient. He had what I call.... patience for patients!!! Thank you for this elaborately educational video. I will be sure to take it to my next doctor's visit to compound the interest. My ❤ is thankful.
I need a little help interpreting my 23& me download to Genetic genie shows heterozygous for MTHFR c665C>T which I think is the same as C667T but the alleles are called AG rather than CT and I’m not sure why.
Dear respected doc, the video was extremely informative, very well explained with all the necessary details, the only problem was the annoying music in the background which was causing distraction & making it difficult to concentrate. Thank you so much for this extraordinary video & God bless you.
Great video!! Your channel has helped me understand so much! I've been taking L-methyfolate for a few weeks now and realize I'm dreaming extremely often again. Even with interrupted sleep, I've still had dreams!! Overall fatigue is improving. Anyone else have similar experiences?
This was an excellent presentation! I do know my MTHFR status & so does my husband, therefore, we know that our kids have this variant, as well! I wish that more people were aware of this. Thanking you for doing your part in the promotion of the MTHFR knowledge! ✨⭐️✨
This doctor is very generous and methodological in her dispatch of essential knowledge of body pathways and nutrients needed to live well. I always look forward to her next lecture.
I recently discovered your channel and have been so impressed with your presentation style, especially the lectures. I been scouring YT for information about what may be causing my symptoms. Your videos about histamine intolerance have been eye opening and so helpful. Thanks for working so diligently and seriously on the gut biome issues. One thing I would suggest is drop the distracting music if it can in fact be called music. In most of the videos I need to pause and calm down. The background noise is so intense causes another of tension. Thanks!
You break it down to laymen terms and appreciate your time frame for results (6)months. I have started all the supplement recommendations and look forward to having my homocystine levels checked. 5 stars.
I was told I’m double homozygous abnormal, but never knew how much of a difference it made. It recently has been literally killing me, and I am bipolar (thanks MTHFR) so it’s put me at the edge of what I can handle. Thank you so much for this info, my doctor isn’t even aware of this gene.
I stumbled upon your excellent video while researching methylation/MTHFR/Lifestyle medicine and looking for a short, simple but accurate explanation. Yours fits the bill perfectly, and is the best I have found so far. Keep up the good work
Thank you for making this easier to understand and including what to look for in our blood work and supplementation to help us. This could be the answer we have sought for over 20 years.
@@drrajsree For a layman the CDC page "MTHFR Gene, Folic Acid, and Preventing Neural Tube Defects" seems to contradict with the info in this video: "5 things to know about the MTHFR C677T variant and folic acid People with MTHFR C677T variants can process all types of folate, including folic acid. Folate is a general term for many different types of vitamin B9. Folate includes naturally occurring folates in foods, such as leafy green vegetables, citrus fruits, and beans, and several types of folate in dietary supplements, such as folic acid and 5-methyltetrahydrofolate (5-MTHF). The MTHFR C677T variant affects how your body processes folate. You might have read or heard that folic acid is not safe if you have one or two copies of the MTHFR C677T variant. This is not true. Even if you have one or two copies of the MTHFR C677T variant, your body can safely and effectively process all different types of folate, including folic acid." Can you clarify on the significance on the different types of folate, is there some other references on the topic you could link?
@@drrajsree ok, some sources claim that is up to 40% that have at least one impaired gene so perhaps CDC is just living in the past then with their info.
@@cyberfunk3793 Yes it's unfortunate but a lot of vitamins and fortified foods, even prenatal vitamins still use folic acid, but this is very outdated.
I learned I have the 677C T/T polymorphism and this video is so helpful in understanding how to treat it. You are really helping people improve their lives. Thank you!
I can't believe someone made a video on this!! It is so rarely discussed. I have mutations on both my mom and dad's side. A wonderful doc put me on Deplin about 7 years ago. My marbles (brain) are still intact but a lot of other health issues. Thank you. Thank you!!!! I will add some of what you suggested.
Dr Rajsree…Thank you for all your videos. They are awesome and informative. I truly wish more doctors would be like you!!!!!!and not just default into being a new age pharmacist. Thank you for what you do! Your work Will help lots of people even the ones you cannot physically treat in your practice. I know these videos probably take up a lot of your time but we appreciate it
@@drrajsree I want to reiterate what the above poster said x1000. Your time and passion are a Godsend and labor of love that we all appreciate beyond words. Especially those of us who have an assigned allopathic doctor who just shuffles patients in and out as fast as they can, will not tolerate being asked questions, or requests for particular tests. 💛
Thank you so much! This was so informative, I couldn’t understand why I can’t seem to loose weight & if I do it’s not very much. Instead of prescribing diet suppressants and all kinds of weight loss gimmicks, more doctors should be looking into this, which could definitely be the root cause of people having such a difficult time loosing weight & just continuing to get bigger & bigger, in addition to developing more & more health problems. I am going to get tested for this. I can’t even thank you enough, your video was amazing, very informative & easy to understand. 👏🏽👏🏽👏🏽
Another great video, nicely drawing out how to identify and overcome some of our inherited genetic issues. Thanks for supplying such an important knowledge in understandable means and providing practical advice how to proactively mitigate it!
You have helped put my fears at ease. I first learned that I have the MTHFR mutation almost two years ago. Homozygous and had my son tested with the same. The dietitian who gave me my results scared me to death!! She said “YOU DO NOT METHYLATE!” I obviously have it pretty bad and I’ve been feeling real bad lately. But I’ve gotten back on all the supplements I was given by that clinic. It’s very expensive but well worth it to know this is real. You definitely explained it better and I’m slowly learning and understanding more about it. Thank you so much! 😊
My son just tested positive for the gene mutation. Both he and his father have super high hystamine (allergic to everything) this video is a lifesaver-thank you!!!
Hi I do have this gene mutation along with DAO gene mutations and others that make my histamine super crazy high, did your husband and son got better after this treatment?
Indeed, you are a gifted physician and teacher. Though may I ask that on other videos, or this one, that you turn the volume on the background music way down? Its distressing to filter music competing for the valuable information that you are imparting, especially those with depression, ADHD, anxiety. It's too much chaos to the ears. Many thanks. I love the video and your information.
What's even more mindblowing is that because MTHFR can reduce B12 B9 absorption, ADHD symptoms can appear from lack of B12 and B9 - BECAUSE the vitamins are not giving you that dopamine / serotonin gain, THEREFORE is ADHD a vitamin absorption deficiency because of MTHFR?
Thank you Dr. Nambudripad, I have been following methylation for many yrs, since the Israelites first published their findings. Out of all teachings I have experienced, yours is outstanding. My cardiologist has me taking one pharma you mentioned but my insurance will not pay for it even though it is a major answer to all of my physical needs. It's amazing, the positive change in my attitude and physical health.
Thank you so much !! I have been struggling with many issues only to be my own advocate and mentioned this to my primary care doctor, who then checked my homocystine levels which were through the roof at 49 !!!! I do have one copy see if I get the correct vitamin B supplements if this will turn it around with a healthier lifestyle and exercise. Thank you so much for this information. It is invaluable. I appreciate it so much thank you again.
I have been looking for information for a very long time about what this enigmatic MTHFR actually is. I wasted a lot of time on some confusing explanations in other videos on YT. Only Dr. Nambudripad explained in simple words what it is and what it is used for in the body. Thank you very much Doc!
Excellent, as always. I stumbled upon this video shortly after I messaged you my results...I should have known you had an awesome and informative video on the subject. Thanks!
I suffer from these very problems. I just had a genetics test done and this is something that came back. I have no understanding of this but your video has given hope that I could possibly see better results moving forward. I’ve never ate veggies like I should have and I’m definitely paying for it now. Ty
@@boomerang0101 Hi bro I tested it in a private lab in belgium. I am in france. I have no mutation of this gene. I reduced already my homocysteine with b complex vitamines (high dosage). Check for a lab near your place that test it and take a good vit b complex.
@@thibaud_92 ya man need to get my mthfr checked. However the walsh institute claims that mthfr testing is useless. Btw I started taking Life extension b complex a few days ago and feel great. I switched over from a lower strength brand. I also take 100mg benfotiamine as recommended by EOnutrition.
Wonderful video, but I want to point out one consideration to keep in mind. On top of the MTHFR and MTRR genes, another one to keep an eye out for is COMT - which complicates the process a bit if you have. COMT, like MTHFR, has numerous functions I won't go into; but relavent to this video & MTHFR positive individuals is it affects the 'treatment plan' since Methylcobalamin isn't recommended (and methyl-donors in general for that matter) In terms of vitamin b12, hydroxocobalamin is generally seen as the best / most accepted form for individuals with COMT; or COMT + MTHFR. The issue is its not super bio-available in oral form, so you might have to speak with a health care provider about higher doses; sublingual doses; or injections Alternatively adenosylcobalamin also supposedly works, but my knowledge is thin on that specific varient. And then in terms of what form of B9 / folate to take, I'd also recommend speaking with a HCP since it complicated the process, depending on what combination of genes you are (homo vs hetero) and your individual response. Some do fine with methylfolate, some require lower doses, some require alternative forms. I'm not your HCP so I won't be making any recommendations on that.
Thank you! Thank you! Thank you!! So grateful that you made this video. Just got tested and I had no clue on what it meant and what to do about it. You gave us just that! Thank you! You are serving your purpose!! May God bless you 🙏
@@drrajsree Dear Doctor, thank you so much for your video. I have a mutation of factor II protrombina G20210A eterozigote and the mutation MTHRF C677T eterozigote. I would like to know your opinion and what should I take. Thank you. Nadia Blasigh
@@nadiablasigh377 Methyl B. Complex is helpful. We ship throughout the US: dr-rajsrees-public-supplement-store.myshopify.com/collections/frontpage/products/methyl-b-complex
@@drrajsree I live in Italy. Could you deliver to Italy? My D-Dimer result was high too - 1257 and two days later I resulted positive to Covid. I was practically asymptotic. Do you have any suggestions on how to bring it down?
Amazing!!!! Ive been sick for 6 years with chronic nausea and after so many tests and imaging..still no answer. But I have signs that point to MTHFR issues and after watching your video I will try to get my doctor to run labs looking for this. Wish I could see you for help! Blessings!!!
This video is great! Question if you dont tolerate well the methylated B complex, do you recommend adding the glutathione or just doing the glutathione alone? Thanks!
My sister had the #1 symptom of MTHFR. She conceived a child without a skull. He delivered at 7 months and died 5 minutes later because his brain was crushed during delivery. My niece (different sister) had the defect identified prior to conception. She took the folate and B12 supplements recommended by her doctor and conceived twins. Penny was 2.9 lbs and Mark was 5 lbs. Autopsy on Penny's umbilical card show 1 missing artery. It was the supplements that enabled their birth. 👶👶🥰
Will humans please stop reproducing already. The collective human gene pool and corresponding microbiome have been systematically massacred to the point where the offspring coming out are literally piles of goo. JFC enough is enough. What on earth is the matter with you people.
What a wonderful explanation Thank you dr. I found out that I am heterozygous. 2 months ago my homocysteine was 46 and by taking 15 mg. Calcium Folinate daily it came down to 17
Really enjoyed this presentation - very clear and easy to understand. I did find the music to be annoying and distracting, however. The video would be fine without it or at least turned down a lot. Keep up the great work of informing us all! thank you.
Great video. For those who want TMG as well, would we take Methyl CpG in addition to Methyl B Complex? Or instead of? I'm assuming just the CpG and not both.
Four years ago I had blood work done for MTHFR because my Mom said she had it. I’m a 31 year old female and want to have kids soon, so I’m taking this seriously. I have suffered from migraines (magnesium helped cure those), anxiety, depression, and low energy on and off for years. Now I know I am MTHFR C677T heterozygous and currently take the Methylfolate, however my doctor wants me to go to a Vascular Specialist to make sure the supplements I’m taking work in conjunction with my hormonal BC before I stop taking BC and start trying for children. Do you know if a Vascular Specialist is the right person to help with MTHFR? Seems like most doctors I mention this to are unaware.
My family found out we had this and I have not been the same since I was 16 year old and I'm 23 now and it has eaten me alive I am glad you made this video and help people understand what is happening to our generation and the one before Deuteronomy 28 I am a 70% and it made all my anxiety depression health issues and everything go away once I found this out and got the right stuff for it
@@mamabear6169 I take these vitamins called smarty pants with an owl on them magnesium potassium pills sundown plant matter not chemical made and I eat lots of greens like broccoli garlic you know farm organic food do not eat any clover valley and great value food it makes it worse especially the milk found hiland non GMO gluten free milk is okay
I have MTHFR and a systemic nickel allergy syndrome, many supplements for methyl B12 have nickel or cobalt used in the making of them that are not ideal for SNAS. Do you have any advice for what would be best for me? I want to be healthy but im facing alot. Thankyou in advance 💖
Thanks so much for watching. I cover COMT in my video on Estrogen Dominance you might like: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-hqmz0ul0EhY.html
Thank you for this info. These supplements are so expensive. I’m looking at life extension brand. It’s only $10 and has great reviews. Wondering if this is ok. I see the difference is calcium and d I think. Thanks again,
Hi, I recently completed a Genomind Pharmacogentic Report (24 Gene) and one of the many defect genes I have was the C677T: C/T. My doctor recommended taking L-Methlyfolic and and exercising since antidepressants don’t work for me. The L-Metyfolic worked right away (next day) but only worked great for about a week. I don’t feel my doctor knows anything about the mthfr, so it leaves me doing my own research. Do you feel having my homocysteine levels checked it will give me an idea on why the folic stopped working? And if my homocysteine is very high, will the Methyl CPG, be a good option? When the Methlyfolic worked for me, I felt so normal for the first time I can remember. I really want that feeling back. I felt happy and very sharp for the first time ever. Thanks you.
Hi , yes it's good to get your homocysteine checked. If you're in the US, we carry Methyl B complex and Methylation Support -- both are great for MTHFR. dr-rajsrees-public-supplement-store.myshopify.com/collections/essential-vitamins/products/methyl-b-complex dr-rajsrees-public-supplement-store.myshopify.com/products/methylation-support?_pos=1&_sid=58ca8f9cd&_ss=r
Truly, I have watched videos on MTHFR gene mutation, and by FAR ,this is the best !!! Thank you . I am pre-diabetic , have high cholesterol, IC, and pulminary risk factors, and my histine level is high , lots of inflamation . I know i haven't been tested and want to - but since I've added pre/probiotics , some methylation donars such as berberine and creatine . I take natural mineral drops (just a little in water sipped thru day) , grounding/earthing , saying grattitude orayers in the morning sun . I take methyl B-12 sublingual and pull weeds for an hour and sweat . I drink 2 caps of activated charcoal mixed in water right before bed - and just making these changes i feel no depression , less anxiety more hope . I also do NOT eat sugar - trying to stay clear of refined foods . I love how you explane in layman language that we all can understand - thx again - a new subscriber for life ! Bless you . I hope that everyone here reading this is blessed too with great health and long , happy life . ❤️
I just received my gene study and watching this video reallllllly helped me understand what the paper work was explaining. Thank you! Great advice too! I will be sure to talk with my doctor about the supplements you have suggested.
Talk with your doctor?! Conventional doctors know virtually nothing about nutrition. They know about pharmaceuticals. Unfortunately, physicians like Dr. Rajsree are very rare.
Hi Dr. Rajsree, I totally enjoyed this video for all the info you provided. However, I do have an issue with your recommedation of 23 and me d/t all the issues associate with them. Blood test from a trusted provider sounds like a better option for me. All the same, I have leart a lot from you and I hope tyou continue to offer such informative videos going fwd. I have subscribed to your your network and I will continue to follow up with you as long as I find value in what you offer. Thanks so much for this video, I loved it and was well informed. Please keep up the awesome job you're doing. Many thanks!
Thanks so much for watching! 😊 You can test for MTHFR through standard labs nowadays like Quest diagnostics, although it may not be covered by insurance.
If you have an MTHFR snp chances are you’ll have an eNOS snp. So you’ll struggle to make Nitric Oxide via the arginine pathways. This means you’ll have to source NO from nitrates to nitrates and the gut and oral biome You’ll find this in leafy greens. This will help with vasodilation, immune health and neurotransmitters production. You’ll feel good. There are oral nitric oxide testing strips for saliva testing available on line. It’s really helped me.
Thank for this wonderful information, it was very well presented but it was very challenging to watch this with the music, for me it detracted from being able to hear the great information you shared. I’m sorry to say anything negative bc this video really seems on point. I’m homozygous 677 with so many health challenges, I’m grateful I’ve had a wonderful integrative health team but I am currently at the point where I really need someone to connect some dots. I’ve learned it’s going to have to be “me” who does that, we have to be our own advocates and take better care of ourselves in every way🌻🌷
Love your videos and thank you so much for sharing such important facts. This is the first time I’ve heard of MTHFR. I was wondering if you’ve been able to reverse RA with any of your patients with the supplements and food you mentioned or what was suggested for them that reversed RA. Thank you so much again for such an easy to comprehend detailed video.
You would like my video on Autoimmune Disease which applies to RA and at the end I present a patient with RA who went into remission with my protocol: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-loIbxqmNOwc.html
This was excellent! I wonder about overmethylation, though. I'm still learning about MTHFR, but it sounds like many people with an MTHFR mutation cannot take too many methylated vitamins at once without having some pretty rough side effects.
It took me forever to clearly understand this concept and even now, as a citizen scientist it’s difficult to grasp the chemistry of it. I guess that’s why this brilliant lady is a doctor and I’m not.!! lol…. I don’t consider her a regular doctor though. She has a much deeper understanding of metabolic health. Which is everything!!!!
Good day, many thousand thanks for your information. In Germany there is no information about this problem. I have Mthfr, unfortunately hardly anyone could help me here. I am very happy.
Thank you so much for sharing this knowledge in a way that makes it easier to understand. I recently found out I have one copy of both variants of the mthfr gene mutation. I had 3 strokes back to back b4 I found out. I'm only 41 years old. This has all been so scary. And none of the doctors that I've been referred to have a clue about this gene mutation. They just want to push stroke protocol medications on me. Cholesterol meds/ even though I have low Cholesterol. Blod thinners even though no blood flies were found and when my hematologist did blood clot tests and my blood took longer to clot then the average range. None of it made sense to me so I refused their medications and they have been giving me heck for it. So grateful to have came across this video. 🙌 Finally some answers of things I can take that will help and make sense. Thank you 🫶
Wow amazing explanation, so easy to understand I live in Canada and not easy to get help with this , now if only I can find someone to look at my results without having to spend $100s of dollars Thank you Dr
Best explanation I’ve seen!! What company do you use to do the MTHFR test for your patients? Also, do you have any brand of vitamins you recommend specifically for children?
It can be ordered through Quest diagnostics although expensive. It's more affordable to use 23andMe and then download the raw data and upload to Genetic Genie.
I've seen many videos on this and this one is by far the best. Illustrations and explanations done in a easily watchable not too long format. Great for those of us with ADHD. Thank you. I know it's a long shot to ask and know you're probably busy. But do you recommend natural sources of b12 from food as well as supplements? Like with folate. Only I eat a plant based diet and have been worrying and been thinking of adding egg and salmon back into my diet. Issue is that I haven't been tested yet but my family and I have many of the symptoms and now nephews and nieces are suffering too. Depression, anxiety, ocd, adhd, autism, hypermobility which could also be related, which effects circulation and other collagen related tissues and not just joints. I'm trying to get my dr to refer me and waiting to hear back. Would appreciate if you could say what your thoughts are about salmon and egg. Many thanks again.
This is a nicely explained introduction to the topic. For those of us who are scientifically inclined, could you point us to some sources in the literature to back up the points you made in the video, particularly any studies demonstrating association of MTHFR mutation with the symptoms you mention, and/or effectiveness of b-complex supplementation for said symptoms? Thanks!
You showed Folinic Acid in the "MTHFR Domino Effect" slide. What do you think of other Doctors now saying Folinic Acid and other B12s (Adeno and Hydroxy) are options for people with MTHFR but also sensitive to methyl donors?
Thank you for such a wonderful video. It explains everything so well. I've been looking for a video exactly like this, organized and it helped me understand this gene mutation so much better. I'm looking for a doctor in my area that understands the importance of this and my only question is how do we find professionals around the state who can help with this?
Interesting video. Still trying to wrap my head around the concept. I had an OAT test that shows Low B6, deficient B2, low glutathione, among some other things like high oxalates. I recently started having digestive issues and have been exhausted. I have the 1298 heterozygous. It was fascinating to discover that website where I could upload my 23 and me file to discover that. But I am still not exactly sure what, if anything, that variant means or if it contributes to some of these new health issues. Your videos in general are helpful, thank you.
