Two Main MTHFR Variants Explained: MTHFR C677T and MTHFR A1298C 

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I have the same mutation and have autism too. I’m blown away.

The motherfu$@er Jean is what it needs to be called. It sucks !

If u weren’t meant to survive you wldnt have. Some of us may have bad genes but that doesn’t define us. Our conditions may cause us 2b or look differently but, they don’t make who we inherently are. Look up epi genetics. N give urself some grace, everyone has something they are dealing with. ❤

So I got tested and I'm 1298cc. I have two variants . So I'm assuming I got one copy from each parent. Still trying to figure this out n just found this out at age 54. Explains a lot for me though. I do have your book dirty genes.

Those disorders are mainly caused by methylation and neurotransmitter issues (in simple terms).

@@Paul-hu1ht Yes

Wow

Thank you!

Same. I am wondering what % reduction we have with this combination?

the info you shared about hangnails is very interesting. I did the 23andme swab 10 years ago & then had MTHFR tested thru bloodwork. I have 2 SNPs, one 677 & one 1298. I have had weak fingernails all my life (now 70) & some issues w hangnails. I would be interested in the form of magnesium that you now take as there are at least 10 forms. You mentioned about anemia, well……my hemoglobin & hematocrit are too high but my ferritin is ok??? Any ideas are welcome😊

@@annettewebster296I’m not expert myself but I’ve tried many forms of magnesium. I take magnesium gyl. now with magnesium oxide I believe women need 400mg. Take according to ur ability with stool softening. But I’ve recently been told magnesium leached calcium…so there’s that. Anemia is hard to treat, I’ve used diet specifically black strap molasses. Idl the taste much but it’s helped with bruising, as I can’t take iron supplements. For the 677T variant, I was put on Methylated b complex specifically Thorne. They seem to have boosted energy levels at first and taken about a yr or so to get my b12 levels rt. For me that’s 3 a day. It’s a bit of a chore, but I was told check all my foods for folic acid or folate. That means not all “organic” is the same. If it’s labeled for “enriched or something like this” think it’s not safe. Less is generally more for those of us who have this condition. So in foods look for the lesser ingredients that do not have added folic acid. I’m still learning myself and didn’t know about the hang nail thing. Good luck

My genetic testing also revealed I tested high for severe combined immunodeficiency disease. The reason I did this testing on my own was because of my family history of cryptogentnic Liver disease and autoimmune diseases. I lost my mom, aunt, uncle, grandmother to this Liver disease without any answers. I was sick a lot as a kid with multiple uti's, sicknesses, lung infections. Fast forward I've been diagnosed with stage 2 liver fibrosis and 5 autoimmune diseases. My uncle has crohns and other issues but is still alive on my mom's side. The problem is I can't get any of my Dr's to do the genetic testing or even listen to the fact that I did.

In theory, it should work but I don't have evidence. If one already has sufficient creatine levels, then taking more won't help. Phosphatidylcholine may help instead as that also is a big homocysteine producer during the production of it. I'd look into Homocysteine Nutrients or Optimal PC.

@@DrBenLynchIs Creatine measured in a standard blood panel? My homocysteine runs high (currently around 15). I have taken Homocystex Plus off and on for several years but can’t get it down to around 7. Looking for answers.

not familiar - haven't looked into it

you dont supplement based on SNPs - you supplement based on need. SNPs identify vulnerabilities - they don't dictate them.

The answer is yes you can. Track homocysteine with blood tests. Aim for about 7 or 8. Also methyl B vitamins help as well especially B12.

@@chrismyers9951 thank you 😊

@@chrismyers9951 didn’t know the ideal range Tysm

He is saying that the supplementations are what is allowing the babies to survive to term, but because they already have the variations they will struggle with the downsides of them through life. They would have otherwise most likely not survived to term without the supplementation support.

@@tinad6812My neighbor had never heard of MTHFR……her daughter had 10 miscarriages & finally had 2 kiddos that are now teenagers.

Not everyone can tolerate them - they are hard core. Remember, it’s about the sum total of SNPs, not just any one in particular