A drug to CURE ME/CFS (and Long Covid) one day? Introducing MITODICURE!

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As of yet, there is no ME/CFS (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome) specific drug. Rather only repurposed medications. That could change thanks to the amazing work of Prof. Klaus Wirth who has identified a compound that could make Post-Exertional Malaise IMPOSSIBLE. And if PEM is impossible, the physiological burden could be lowered so much that healing becomes possible (and therefore how this drug could represent a cure at least for some patients). In this video, I talk about his start-up MITODICURE, the principle of the drug/treatment, and what still needs to be done (don't get your hopes, funding is still needed and the trials will take time, but this is a move in the right direction). This video is also relevant for Long Covid and POTS.
Affiliates:
Normalyte (most helpful supplement I've ever found for ME/CFS) - affiliate link: normalyte.com/...
DNRS Brain retraining (helped me recover from my first round of illness and still very much recommended) affiliate link - retrainingtheb...
Timestamps:
1:35 Background to Mitodicure
4:23 Pathology to be targeted
7:37 Drug Mechanisms
9:41 Development Pipeline
10:48 Personal reflections
Links
www.mitodicure.com
Wirth and Scheibenbogen hypothesis - pubmed.ncbi.nl...
Wirth 2023 Charite presentation (at very bottom) - mecfs-research...
High sodium content within cells of ME/CFS patients - www.ncbi.nlm.n...
Frankfurther allgemeiner piece (behind paywall) - www.faz.net/ak...
My name is Patrick Ussher and I am an ME/CFS patient. I have written a book on POTS and also about thirst in ME/CFS, POTS and Long Covid.
Personal website (including details about consultations service): www.patrickussher.com
My (free) book on thirst in ME/CFS, POTS, LC: www.themythofprimarypolydipsia.com
NB: This video is for educational purposes only - please always consult a doctor about any health issues or changes.

Опубликовано:

30 сен 2024

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Комментарии : 57

@MyFriendPeter 3 месяца назад

Never say never as they say. Its heartbreaking and criminal that so little is invested into research for this debilitating ilness. I hope with all my heart that investment is found especially how taxes etc are so massively wasted by government. Thank you as always for fighting the good fight

@me-cfs-strategiesforhealing 3 месяца назад

Thank you for the kind words It’s unreal how the very sick are just sidelined. If it happened with any other disease with such a severity burden, there would be public outcry What a world

@MyFriendPeter 3 месяца назад

@@me-cfs-strategiesforhealing yes it truly is criminal. Even more so with the undeniable rise after COVID showing it is a real severe illness, yet it is still pushed to the back burner and undermined.

@OscarPerezPousada-sn2do 3 месяца назад

This is incredible! Thanks for posting. Some key points for anybody who wants a summary: • research has found patients with ME have dysfunctional potassium - sodium pumps which are part of the mitochondria of every cell meaning that the cells are becoming flooded with too much sodium which also leads to a build up of calcium. The cell becomes dysfunctional and can’t adjust when a patient exercises, leading to a crash. • Mitodicure are working on developing a pill which will address the faulty pump, making PEM impossible. They hope that if it’s impossible to crash that the body will then be able to heal itself.

@me-cfs-strategiesforhealing 3 месяца назад

Cheers and great summary!

@curtiste3235 2 месяца назад

Very nice summary. Thank you! 😊 So helpful for those of us with Fibro-brain.

@Si-Toecutter 3 месяца назад

Thanks for your channel, it's giving me hope for my son

@me-cfs-strategiesforhealing 3 месяца назад

Thank you, that means a lot to hear

@NikkoYM 3 месяца назад

In the news a few years ago: Warren Buffett's wife gets requests from people for financial help. They read through all sorts of letters and choose whom to help. This was about 10 years ago, so I'm not sure if they're still doing this. I think I saw it covered on the PBS Newshour. Maybe if there was a collective effort from the researchers, etc. they could try and contact them. (Or maybe the Bill and Melinda Gates Foundation). I just remember seeing this about the Buffetts on PBS.

@AhmedHOmar-vz4qz 3 месяца назад

There's also some good news from Argentina, there's a drug called rintatolimod, As of 2022, it was approved in Argentina and is ready to "Launch pending FDA export authorization"

@Anchor7 2 месяца назад

Isn't that genetic for Ampligen? Unfortunately Ampligen hasn't shown to help much from what ive read

@davidkohl8962 3 месяца назад

This is amazing news.. please let it be true 🙏

@me-cfs-strategiesforhealing 3 месяца назад

Hopefully…there must be a wealthy benefactor out there who’d like to take it on

@c-p1976 2 месяца назад

WOW! I hope and pray this is a real thing! The best news I've heard in two decades of coping with this illness!

@DanielleLegacy 9 часов назад

My question: how do we know that the sodium/potassium pump dysfunction is what's causing PEM?

@DanielleLegacy 9 часов назад

So, how do we volunteer to be in the trials? I'm in the US. I know this is wishful thinking, but thought I'd ask anyway.

@StreetHawk77 3 месяца назад

Fingers crossed, although if BC 007 is anything to go by we'll have a very long wait

@me-cfs-strategiesforhealing 3 месяца назад

That might well be the case unfortunately

@maricargarcia3074 3 месяца назад

When this it's available.@@me-cfs-strategiesforhealing

@me-cfs-strategiesforhealing 3 месяца назад

It has to get funding first. Even with that, medicine moves slowly. It's years away yet I'm afraid.

@maxwassermann3171 3 месяца назад

I really hope that BC 007 was just a very bad example.

@paulssss5463 2 месяца назад

@@maxwassermann3171 why is it a bad example? If BC007 works, it may well take 3-5 years

@lessons9745 3 месяца назад

Very interesting to hear what's going on from across the pond .Here in the USA we have Dr David Systrom who has done iCPET testing and found preload failure in those with ME/CFS/POTS He recommends using more salt and compression stockings plus Mestinon ,LDN, Fludrocortisone,midodrine and beta blockers .He believes the preload failure that presents without intrinsic heart or lung disease is caused by autonomic nerve dysfunction ,low blood volume ,mitochondrial issues and even shunting issues . A cure would be nice ..but how many things have an actual cure ? Hope you are feeling OK today Patrick !

@lessons9745 3 месяца назад

I wanted to add that ever since I got "pots " my calcium levels rose to the high side of normal or a couple above normal .

@me-cfs-strategiesforhealing 3 месяца назад

Yes, I’m aware of Systrom’s work and klaus Wirth also includes it in his hypotheses. So many vicious cycles ongoing in the illness. Time will tell if mitodicure is powerful enough to reduce the load enough if the body can then heal itself For now we do the best we can

@davidkohl8962 3 месяца назад

@@me-cfs-strategiesforhealing Are there any clues as to what this drug actually is and any potential supplements that replicate its effects?

@me-cfs-strategiesforhealing 3 месяца назад

There's some speculation on the phoenix rising forum if you want to search for mitodicure there. Apart from the fact that it will normalise the cellular sodium overload, I don't know. I've looked but not found anything :)

@lessons9745 3 месяца назад

@@me-cfs-strategiesforhealing Lots of vicious cycles ! I was listening to this hour long talk yesterday with Lauren Stiles and Cort Johnson ...and Lauren mentioned GLP and dysautonomia so I looked it up .. GLP ( glucagon like peptide ) is released 10 min after eating ..it activates nerves in the gut ... sympathetic nerves that help control insulin and peristalsis . GLP also sends messages to the brainstem and it can cause tachycardia because it decreases parasympathetic activity .GLP also influences kidney function ,stimulating diuresis and lowering blood pressure ... ....That's interesting and gives a lot of insight into lots of familiar symptom complaints !

@Anchor7 Месяц назад

Although I don't know Billionaires, I do know people with deep pockets who may be interested. How do I get ahold of Prof Klaus?

@me-cfs-strategiesforhealing Месяц назад

That's brilliant. Write to me directly (via the contact form on my website which is just my name - Patrick Ussher) and I will put you in touch with Klaus. I'm in contact with him often.

@Anchor7 Месяц назад

@@me-cfs-strategiesforhealing hey there, I will reach out over the weekend. Thanks!

@me-cfs-strategiesforhealing Месяц назад

Cool, look forward to hearing from you

@magdaismail4595 2 месяца назад

Incredible news 🎉 fingers crossed 🤞🏻

@simonpkershaw 23 дня назад

Further, just listening to mr Wirths 2023 presentation….does this guy know that he is talking about the key to most of the mechanisms behind long covid, does he know the spike protein appears primarily toxic to endothelial cells? Correction yes he does!!

@joredfearn1 3 дня назад

Thanks so much for using some of your precious energy to create this and share. Really positive news. Actually gave me goosebumps / nearly made me cry when you spoke about the pill's projected mechanism resulting in PEM being impossible. And therefore taking that stress of the body to actually heal. Imagine!!! Let's manifest this!

@me-cfs-strategiesforhealing 3 дня назад

Thank you very much! Likewise, this is the pill is what gives me the greatest hope. But, as always, ME/CFS and money for funding is tricky to come by. But let's indeed manifest it and if you happen know of any billionaires, maybe mention it to them!

@francaisediesachsenliebtsa8679 11 дней назад

Hello , I live in Germany . I has EBV and maybe long covid , CFS, I ve tested my mitochondrie and there are no optimal functional . I would like know more about that. I hear many thing about treatements, clinical try... but nothing come. It s always hope and disapointed, ex : IVIG, BC007 , Bruce Patterson protocol.... When come all this thing ? Are there still clinical try. Can I in contact with Herr Klaus or a clinical ? Best regard

@me-cfs-strategiesforhealing 11 дней назад

Unfortunately, Klaus Wirth still needs funding for a trial. Keep an eye on Mitodicure's website for updates.

@tomreid8598 3 месяца назад

Would you condiser this a compeditor to Asha-091? Both very early stage mitochondrial drugs. Both likely to be 15-20 years away, if they work. Both providing a glimmer of hope.

@me-cfs-strategiesforhealing 3 месяца назад

Thanks I wasn’t aware of that one but looks like they could well be competitors. But all so far away, as you say

@simonpkershaw 23 дня назад

Thanks for pointing me at this, it does sound like an interesting approach that demands further funding, getting a drug created is one thing but it’s entirely a different league to get it through trials and approval, patients funding it is nowhere near adequate. I’m thinking about the funding though, there are people looking for this because another line of lucrative drug is in trouble!!!!

@me-cfs-strategiesforhealing 23 дня назад

That's exactly the problem - the funding. Perhaps in any other illness, it would be a different story, but it is just hard to get the money in ME/CFS. It would help with post-Covid ME/CFS as well (and of course post 'poke in the arm' ME/CFS) so perhaps emphasising the Long Covid aspect more would help him in trying to find the funding.