Acute Myeloid Leukemia (AML) - Auer Rods - Myeloperoxidase Positive - Hematology & Oncology Series

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Acute Myeloid Leukemia (AML) | Auer Rods | Myeloperoxidase Positive - Hematology.
Acute Myelogenous Leukemia (AML) is a malignant neoplasm (cancer) of myeloid cell lineage (myeloblasts and monoblasts). It's a leukemia (cancer of the blood and the bone marrow). It affects patients between age 40 and age 60 for the most part. Risk factors for AML include Myelodysplastic syndrome (MDS), Benzene, Ionizing radiation exposure, alkylating agents, antineoplastic agents, aplastic anemia, paroxysmal nocturnal hemoglobinuria, and Fanconi anemia. Myeloblasts and/or monoblasts occupy more than 20% of the bone marrow. It can cause anemia, infections, and platelet clots. AML has many subtypes (e.g. M0, M1, M2, M3, M4, M5, M6, and M7). AML is diagnosed by being TdT negative, Myeloperoxidase (MPO) positive, and a hypercellular bone marrow (on bone marrow aspiration/ bone marrow biopsy).
AML = Acute Myeloid Leukemia (or Acute Myelogenous leukemia).
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Опубликовано:

20 июл 2018

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Комментарии : 207

@MedicosisPerfectionalis 2 года назад

🧠 CNS Pharmacology Course: www.medicosisperfectionalis.com/

@martinezbiz 3 года назад

My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.

@alizaismailfunlife Год назад

😢😢😢 may GOD u strength

@YusraYasir-wq8yv 6 дней назад

May you get better substitute

@yellowishpeony2768 3 года назад

Thank you so much, sir! It gives me courage to start reading my actual hematology book, which is kind of dull. I'm once again thanking you for making it easy and fun!

@MedicosisPerfectionalis 3 года назад

My pleasure 😇 Good luck to you!

@daryllacker4787 3 года назад

Great info, my father in law was just diagnosed with aml and this was wonderful to find. For the record he is 84 so the age brackets you define might actually be a little looser.

@MedicosisPerfectionalis Год назад

📝 Download my handwritten notes: www.medicosisperfectionalis.com/

@beste9020 3 года назад

your voice is very soothing, it doesnt make m feel like i'm listening a lecture video, thank you for your work

@dominicaibanylla200 5 лет назад

Never knew I would have so much fun learning patho... I bet it's my fav sub after this .... Thanks a ton

@MedicosisPerfectionalis 5 лет назад

Best comment I’ve received in a while 😊😊😊

@dr.nesreenibrahim499 5 лет назад

I just received my pass result in NBDE part 1exam ...thank you medicosis .your channel helped me a lot in understanding the most hard subjects in pathology.

@MedicosisPerfectionalis 5 лет назад

Yay 🎉🎈🎊

@anvayajadhav9766 3 года назад

I really loved your video! Thank you so much for teaching it in such a simplified and concise manner.

@MedicosisPerfectionalis 3 года назад

Thank you so much 😊

@nandinisingh6695 2 года назад

oh my god i cant believe i am finally able to understand these hematology and oncology topics!!! u are s uch a great teacher!!

@olamideoludoju Год назад

Your hematology oncology videos are perfect medicosis! Thank you. Truly, "medicosis perfectionalis, where medicine makes PERFECT sense".

@MedicosisPerfectionalis Год назад

Thank you 😊

@warunadissanayake2072 Год назад

Its a very simplified version of hematology. Thank you so much.

@NuclearMedicine070 3 года назад

Now ,its very easy to understand because of simple and clear explanation. Thank you so much...!!!

@hannahrosa5485 4 года назад

Once again you hit it out of the ball park. I wish I'd found you years ago.

@MedicosisPerfectionalis 4 года назад

Thank you so much 😊

@paolo6424 2 года назад

Hey! Thanks for your videos. I have one question that has bothered me for days and I can’t figure out… what are the pathophysiological mechanisms of splenomegaly, lymphadenopathy, etc.? Is it due to metastasis? If so, what’s the difference with myeloid sarcoma? And is lymphadenopathy a lymphoma stage of leukemia?

@rovoB 5 лет назад

I have no words. For last 3 months I was so damned about this Leukemia and tried several sources to understand it. This was the best ever possible video for it. Thankyou so much sir. In debt

@MedicosisPerfectionalis 5 лет назад

My pleasure...I am happy to help! Thanks for your kind words...Keep it up!

@rovoB 5 лет назад

@@MedicosisPerfectionalis Do you mind me asking which country are you from ?

@MedicosisPerfectionalis 5 лет назад

Egypt

@rovoB 5 лет назад

@@MedicosisPerfectionalis

@MedicosisPerfectionalis 5 лет назад

😊

@mitanshusharma5944 4 года назад

Always very Good presentation, easy to learn and understand. Hats off to your Hard Work

@MedicosisPerfectionalis 4 года назад

Thank you so much 😊

@rogeryin5777 6 лет назад

very good presentation as usual, very informative.

@MedicosisPerfectionalis 6 лет назад

Appreciate it...This touches my heart...Thanks :)

@mnaga9625 4 года назад

I have exam tmrw and thanks alot for helping me clear up ALL,CLL,AML,CML 👍

@MedicosisPerfectionalis 4 года назад

My pleasure 😇 Can you please help me by sharing my videos with your friends?

@Apratim98 3 года назад

7:46 a/c latest harrison mut. of FLT3 has good to moderate prognosis ,not bad

@akhilchoudhary1263 5 лет назад

Great stuff brother, it was really helpful

@MedicosisPerfectionalis 5 лет назад

Thank you 😊

@Blue_flowerr 2 года назад

Thank you so so much I've learnt a lot from this video especially with the question at the end of the video it really helped understand it better.

@MedicosisPerfectionalis 2 года назад

I am honored! Thank you so much!

@razeed5318 4 года назад

came here because of EMMAN NIMEDEZ ... get well soon lodi

@faezehs6258 3 года назад

You are amazing! Really really amazing😍 thank you so much 💚

@MedicosisPerfectionalis 3 года назад

My pleasure 😇

@NanduKrishnanNKSanandu 2 года назад

earned my subscription and like! Really high quality stuff

@MedicosisPerfectionalis 2 года назад

Thank you 🙏

@sarabaldazo4636 5 лет назад

I was diagnosed with AML last July. After months of arsenic trioxide chemo infusions, I'm almost done with my treatment!

@MedicosisPerfectionalis 5 лет назад

And how is your health now?

@christy8693 3 года назад

update?

@MuhammadImran-ct6hb 3 месяца назад

Are you living???

@kainatkhawaja8844 Год назад

how can we tell the difference between AML and ALL with just clinical presentation and CBC?

@anastasiastoian6014 4 года назад

Thank you so much!!!

@gourangomandal6743 Год назад

U r the saviour of medical students thank u so much

@MedicosisPerfectionalis Год назад

Thank you 🙏

@shashishekhar---- 2 года назад

My father has pancytopenia with 8-9 normoblast / 100 wbc, bone marrow aspirate test indicated fair number megaloblasts and normoblastic normoblasis, does he have leaukemia ? Please answer !

@Medical_Sciences 3 года назад

Lovely explanation, thanks veryyy much ...this explantion very fantastic

@MedicosisPerfectionalis 3 года назад

Thank you so much 😊

@kannankamal5446 3 года назад

Perfect explanation 💥💥💥🎊🎉🎉🎉🎊🎊🎉🎉🌃🌉💯💯💯👌👌👌👌

@MedicosisPerfectionalis 3 года назад

Thank you so much 😊

@subhicshas7553 Год назад

Much easier that what's given in the book for multiple pages !

@MedicosisPerfectionalis Год назад

Thank you 😊

@ADITHUNDIA 5 лет назад

Great videos! Short and clear. I'm not doubting you or anything but please may I know the source of your knowledge. Thank you

@MedicosisPerfectionalis 5 лет назад

I use Harrison’s, Davidson’s, Goldman-Cecil and Goljan

@EfrahNaz 2 года назад

Thankyew medicosis I'm addicted to your teaching method..

@MedicosisPerfectionalis 2 года назад

Thank you 😊

@dianagalvan5854 4 года назад

Could your next video focus on Myeloid leukemia without maturation? Interesting video :)

@gulraizfarrukh 4 года назад

why does wbc count increase in labs shouldnt it be reduced due to the invasion of the myeloid neoplasm? or the labs count the blasts in blood as wbcs too?

@coscoteruel1162 4 года назад

These are great!!!

@MedicosisPerfectionalis 4 года назад

Thanks 🙏 Please help me by sharing!

@kabbohasan6940 3 года назад

You are simply great!✌️

@MedicosisPerfectionalis 3 года назад

Thank you 🙏

@AhmedSamir-jn6kf 5 лет назад

Thank you Very helpful

@MedicosisPerfectionalis 5 лет назад

You’re very welcome, Sir!

@mjk9152 3 года назад

Thank you soo much💙

@arpudajayaseeli4374 Год назад

Thank you and God bless you for your good explanation

@MedicosisPerfectionalis Год назад

God bless you too!

@dr.nesreenibrahim499 5 лет назад

You are the best ,,your videos were helping me a lot in preparation to NBDE exam ..my exam is next week and I want to thank you for these amazing videos

@MedicosisPerfectionalis 5 лет назад

My pleasure! I am so happy that my videos helped! When you pass your exam, please share my videos with others! Thanks!

@dr.nesreenibrahim499 5 лет назад

Yes of course I already told everybody how your videos are the best :)

@MedicosisPerfectionalis 5 лет назад

Thanks, dear! If you have any questions, please ask!

@dr.nesreenibrahim499 5 лет назад

And I have a question about the most common leukemia in general ..? In First Aid it puts CLL as the most common one which I feel is not right ..

@MedicosisPerfectionalis 5 лет назад

According to Harrison's: CLL is the most prevalent leukemia in Western countries.

@ayomideadesina8986 4 года назад

Thank you for making hematology easier for me 😭😭😭

@MedicosisPerfectionalis 4 года назад

My pleasure 😇

@simi2469 3 года назад

Look who we have here 😁

@mrsdiggory3211 3 года назад

this is really useful, thank you so much :)

@MedicosisPerfectionalis 3 года назад

My pleasure 😇

@jacobjasper6269 3 года назад

The age estimate is not correct. Maybe read this article: Shallis, R. M., Wang, R., Davidoff, A., Ma, X., & Zeidan, A. M. (2019). Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges. Blood reviews, 36, 70-87. It is really good.

@chahboua 2 года назад

Thank you

@sdilaware69 6 месяцев назад

I understood now ❤ur skills

@haniehmohammadi3454 3 года назад

So helpful👍🏾👍🏾

@bangtancrackheads1704 2 года назад

thank you you made it easier

@MedicosisPerfectionalis 2 года назад

My pleasure 😇

@jiedong3196 2 года назад

Thank you thank you Dr Medicosis perfectionlis

@MedicosisPerfectionalis 2 года назад

My pleasure 😇

@ferdoushtahsin4896 4 года назад

Your videos are awesome😍😍😍

@MedicosisPerfectionalis 4 года назад

Thank you so much 😊

@iuw3ug Месяц назад

Thank you very much.

@MedicosisPerfectionalis Месяц назад

My pleasure!

@drimranabdullah2516 5 лет назад

Great video....and waiting for much more

@MedicosisPerfectionalis 5 лет назад

Thanks...Sure...Can you give me examples, please?

@drimranabdullah2516 5 лет назад

@@MedicosisPerfectionalis Thanks for your concern.... I am in the field of medical oncogy... and want videos related to my field.... Especially pharmacology.... Pathogenesis of different tumors... Modern recent developments in the Drug development in different tumors

@MedicosisPerfectionalis 5 лет назад

Got it... Thanks

@fromhavenk7112 5 лет назад

Thanku thanku thankuu.......U r great sir.....keep it up .👍👍👍👍👍👍👍

@MedicosisPerfectionalis 5 лет назад

I sure will 👍👍

@RfR442 2 месяца назад

Acute lukemia means precursor cells(myeloblasts) are seen not that patients are younger. Am i wrong?

@chickennuggetlover5560 4 года назад

I couldn't watch the entire video... My friend has recently been diagnosed with this. Could you tell me if there is a cure?

@michaellam2622 3 года назад

feed your friend chicken nuggets

@user-rk8bn3sm2g 3 года назад

Thank you so muchhhhhh

@drharshmpatel 3 года назад

Is there 19:11 or 9:11 ????? In the book there is 9:11 for intermediate.

@tasneemalhady8535 3 года назад

great thanks you👍👍

@dibyasattwakarmakar Год назад

Thank You , Sir

@MedicosisPerfectionalis Год назад

My pleasure 😇

@marionvanstaalduinen8562 2 года назад

I was diagnosed with aml at 74. I have been in remission for almost five years and most recent bloodwork was good. If the expectation is I will not live beyond five years should I be concerned?

@MA-yt4xf 2 года назад

Unless it comes back I would not be concerned. And even if it comes back there are always treatment options. Wishing you the best.

@marionvanstaalduinen8562 2 года назад

@@MA-yt4xf not for someone my age. I had to leave my province for 7 months to get the original treatment.

@MsLuckyleo 4 года назад

Great videos. I am learning a lot. Thank you very much. As a person who is in cytogenetic, I noticed some things. It's cytovenetic not cytogenic. And t(15;17), t(8;21), not t(15:17), t(8:21). It should be semicolon between different chromosome numbers. Sorry to pick those up. Thank you for great videos. I will keep studying hard!

@MedicosisPerfectionalis 4 года назад

You’re absolutely correct! Thanks a lot! Please let me know if you see any other mistakes.

@MA-yt4xf 2 года назад

2:34 "for the 9th time" 😂😂 thank you for making me laugh when I least expect to

@MedicosisPerfectionalis 2 года назад

Haha 😂

@0708LC Год назад

Can somebody clear something up for me please? This is obviously leukaemia. So how can we have both pancytopenia and WBC of >100000? Or did I misunderstand the case at the end?

@MedicosisPerfectionalis Год назад

Some patients will have low WBC, some will have normal WBC count, and many patients will have high WBC count.

@52-manupativamsigangadhar16 4 года назад

I think u have to give minimum of two case sheets (like which u have given in this video) in every video . Good luck🤝👍

@MedicosisPerfectionalis 4 года назад

That’s a good idea 💡

@achalakarna9293 4 года назад

Doesnt gum hypertrophy occurs in M4?

@MedicosisPerfectionalis 4 года назад

It’s possible

@payalnayak2176 4 года назад

plz make a playlist on Cardiology as well.....plzzzzz.....loads of love from India.....

@MedicosisPerfectionalis 4 года назад

Thanks 🙏 Have you seen my last videos? They were about Cardiology!

@payalnayak2176 4 года назад

@@MedicosisPerfectionalis Yaa but I need videos about all the disease conditions in Cardiology....plz its a request...plz.....🙏🙏🙏🙏

@birhatyouns2004 6 месяцев назад

Thousands thanks ❤

@MedicosisPerfectionalis 6 месяцев назад

Thank you!

@isseisse715 4 года назад

Nice presentation

@MedicosisPerfectionalis 4 года назад

Thanks 🙏

@noorulsabahmumtaz1077 5 лет назад

Thank u

@MedicosisPerfectionalis 5 лет назад

You’re very welcome!

@DPH1301 4 года назад

Is there a way to differentiate between whether a person's bone marrow stem cells are creating bad blast cells over and over and over.. vs one blast cell that didn't mature and started replicating blast cells resulting in the blood being filled with blasts?... Or is Aml definite that the person's bone marrow is no longer functioning properly and there has to be a bone marrow transplant to stop the leukemia

@MedicosisPerfectionalis 4 года назад

Your question is how to differentiate between polyclonal and monoclonal. If a diagnosis with AML is confirmed, there is an extremely high chance that this is monoclonal (one cell “blast” or one cell line started the whole process). For practical purposes, most of the time, there is no need to perform expensive tests to establish whether it’s polyclonal or monoclonal, because this is not going to affect the management/therapy. Theoretically, there are some tests to differentiate between monoclonal vs polyclonal...They use some immunohistochemichal techniques to calculate the ratio between different antibodies...If the ratio is preserved, it’s polyclonal. If the ratio is altered, it’s monoclonal. This was discussed in my video titled: “leukemia vs lymphoma introduction...Distinctions in oncology” I wish you the best of luck!

@DPH1301 4 года назад

@@MedicosisPerfectionalis Thank you very much, I'm going to watch that video right now!!

@MedicosisPerfectionalis 4 года назад

My pleasure 😇

@maryamgolshiri8107 2 года назад

Perfect👌👌TNX

@lytsyrc_nnamijares8098 2 года назад

My sister in law diagnosed AML last Dec.4,2021 and she died Dec.5 at the age of 31😭

@warhog1337 2 года назад

very sorry to hear this. be strong for the family.

@ffardoun7544 Год назад

@@warhog1337 how and why did uo arrive very late

@dominicmendoza6662 2 года назад

Hi, I have a question, even if I'm awake or I don't always get enough sleep, can I have leukemia?

@MedicosisPerfectionalis 2 года назад

What does this have to do with that?

@DPidginDoc. Год назад

I love the video❤

@MedicosisPerfectionalis Год назад

Thank you 🙏

@DPH1301 4 года назад

What is acute myeloid leukemia without maturation, is there a video I can watch to learn the details?

@MedicosisPerfectionalis 4 года назад

It’s the exact same disease. It basically means that the cells are immature (i.e. blasts). Same diseases, just more severe.

@DPH1301 4 года назад

@@MedicosisPerfectionalis Ok I was thinking it was it's own sub-type of aml, thank you

@MedicosisPerfectionalis 4 года назад

It’s just a specifier

@DPH1301 4 года назад

@@MedicosisPerfectionalis Can fermented food like Kimchi cause leukemia?

@egan2917 2 года назад

Don't worry y'all ...we'll get through it😞

@aamiinyare7849 5 лет назад

Good bro thanku alot 100000000

@MedicosisPerfectionalis 5 лет назад

My pleasure 😇

@bushraliaqat9522 4 года назад

U sh'd be having billions of subscribers uptil now,

@MedicosisPerfectionalis 4 года назад

Thank you so much 😊 Can you please help me by sharing?

@heshamalshami 4 года назад

U r ammmmmmmazing .. i ve got it quickly ❤

@MedicosisPerfectionalis 4 года назад

Thanks 🙏

@aalmutairi7933 2 года назад

Thank youuu!

@MedicosisPerfectionalis 2 года назад

My pleasure 😇

@heshamalshami 4 года назад

But what's denovo AML??

@onignednerb1482 3 года назад

I think it’s when you’re DX stage 4 right away

@thescientist_ir 2 года назад

Love u doctor , love u❤️😅

@DPH1301 4 года назад

7:04 Is there a video on aml inversion 3?

@MedicosisPerfectionalis 4 года назад

Unfortunately not

@DPH1301 4 года назад

@@MedicosisPerfectionalis Ok, was looking to analyze that one in detail...

@secretlover9525 5 лет назад

sir plz i have a confusion ...is it affecting all the process from myeloid forming erythrocytes, monocytes,wbc....or it just affect in processs of making wbc and monocytes....or if just affect wbc and monocytes forming cell then y erythocytes count is reduced.......sir plz make me clear ....

@mbulelombali3856 5 лет назад

All myeloid cell lineages are affected...

@sumankalyan3070 3 года назад

Thank u so much, u came like god to me😭😩😩💕💕💕💕

@MedicosisPerfectionalis 3 года назад

My pleasure 😇

@neginmoosavi3618 2 года назад

beautiful

@MedicosisPerfectionalis 2 года назад

Thank you 🙏

@secretlover9525 5 лет назад

n some videos says it affects myeloid cells and cant b differenciation of it...then how it could affect rbc wbc and monocytes cells when it is nt differenciated from myeloid.

@MedicosisPerfectionalis 5 лет назад

Can you reinstate your question more clearly, please?

@superanimalzz 4 года назад

Does auer rods always mean cancer?

@MedicosisPerfectionalis 4 года назад

We can’t diagnose cancer based in Auer rods alone.

@angeliquemaulit 3 года назад

To my mkm and dad , Thank you for not believing but geez , even my fake friends bullyung me iam still fighting !! My last chemo i think in 2 week it is home chemo so .. to my ADOPTED brother thanks !!

@MedicosisPerfectionalis 3 года назад

Best of luck to you! Stay strong and don’t give up!

@majinvegeta3284 3 года назад

What were your symptoms?

@maioosa1997 4 года назад

The patient is older in AML

@jacksparrow-wq1pb 3 месяца назад

❤ medicosis perfectionalis ❤

@dracula5205 5 лет назад

My mom's sister just died from AML . It appeared all of a sudden in the reports and she died before she even reach a month of the treatment . What could have caused that so quick ?

@MedicosisPerfectionalis 5 лет назад

I don’t know, and I am sorry about your loss.

@ashishpatel7876 Год назад

Younger patients ?? ALM most commonly affects people around 60 years old !! It’s ALL which occurs in children

@user-jhsoshxhs33 2 месяца назад

15-17

@noorulbasarsherazi7989 2 года назад

30 Jan

@mitchbower1878 4 года назад

A few points for those studying from this: - Not really "40-60" as described. Median age is 65, with incidence increasing with age due to accumulated haematopoietic cell damage - AML rarely presents with lymphadenopathy unlike ALL - Bone pain in AML is rare. Bone tenderness in the sternum and long bones due to leukaemic myeloblastic expansion is, however, common (tenderness =/= pain)