Acute Lymphoblastic Leukemia (ALL) - Symptoms, Pathogenesis, Diagnosis - Down Syndrome - Hematology 

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I've reached a new level where I watch your videos for fun.

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You are absolutely brilliant and really have a gift when it comes to teaching! I have told everyone about your channel and wish you all the success! Thank you so much for your top quality work ❤

You deserve more views! I honestly forget that I am studying when watching your videos. Thanks!

Thank you once again. A doctor who once doctored my husband passed away from ALL in January, 2021 after one year of treatments. He was 48. So incredibly sad.

Amazing! Have one month left for my MD Pediatrics exam..your videos have helped me a lot.Thank you so much.

I wish you were my lecturer for all my courses. Very simple, and trust me it takes a lot for me to understand something.

I’m starting to like this hematology thing because of you, thank you for making it so fun to listen to 😂💖

How are you not a doctor???

Best teacher ever seen😍 U r far more magnificient than anyone else Genius u are 👍👍 Stay safe keep going😇

Love your videos, extremely helpful and fun to listen to. You’re awesome!

You are literally a lifesaver, I support you on patreon and owe you so much more

OMG! I just stumbled into your channel and thank God I did! Your videos are really helpful for my board exam preparations. Good work bro 😄

Great video, so recently my nephew of 5 years of age was diagnosed with PRE-B ALL which was a terrible news for us, we fought through it, his first biopsy showed more than 95% blast cells in his bone marrow, however they didnt make it to his blood stream, and his other test was fine as well some cpf or cpr some spine test to see if the brain is fine or not I dont really know I'm not a doctor, Anyway, we started off his treatment and immediately even through in his first few weeks of chemotherapy he started showing good improvements like no more bone pains and could start to walk again and do some normal children chores again, we started seeing hope and him being an amazing warrior started battling hard, he started eating a lot which is quite common since his medical team told us because they started giving him steroids and we were happy that our son is doing well diet wise, he has started to gain weight. Long story short it has only been a bit more than a month into his treatment and his last major biopsy, I call it major because it was supposed to show the percentage of the blast cells in his bone marrow because in that biopsy they also took a tiny bit of his bone as well. The doctors said that the could not calculate the percentage of the blast cells because there number was very less so the machine couldn't calculate it. There are a few things that I'd like to add here, I'm a bit concerned about how chemo can have effects on reproduction, and also his gene panel showed ETV6-RUNX1 fusion. Anyone that can help me understand a bit would be much appreciated. Anyway, what my concerns are that is he doing really fine? I mean we can see the improvements in his health but I'm not a doctor so I cannot know for sure, if please you could share some insights. Thanks One thing that I would like to add here for everyone is Do not lose hope if you are given this horrible disease. Always be hopeful and there is light for sure at the end of the tunnel. Peace

Wow I'm so surprised that you're not a doctor. Your lesson and video are so much better than what I've learn from hospital. Thanks for sharing the knowledge.

Amazing. Thanks a lot for simplifying ALL. Your hematology videos are 💯💯🔥🔥👏

Thank you! Your videos are so helpful!

This channel is just wonderful. Thank you so much.

You are brilliant, funny, a helper, and a doctor. What else to wish? Thank you for your contribution !

Love to watch your videos ! Great job !

Your channel is a blessing, thank you Doctor Medicosis

Thanks ! Was watching this for my review!

I LOVE LOVE LOVE THE WAY YOU EXPLAIN THINGS.

I have been referred to a hematologist for my CBC. I had it taken and had a low WBC count (2.8). I waited 2 weeks for another CBC, and it raised to 3.3 (still low). I looked at the CBC, and it indicates that my Neutrophils are quite low and my Lymphocytes are quite high. I’ve had many viral infections (lasting 3+ months), UTIs, and I’ve started to bruise easily. The bruises sometimes take months to go away, despite them being from minor bumps. I also get frequent mouth ulcers. I’m more fatigued than usual, and my bones and joints ache. I felt like my hair was falling out more than usual, so I got a very short haircut out of frustration. I had very long hair and donated it for cancer patients. I noticed my gums bleeding a bit more frequently as well when brushing. I haven’t met with my hematologist yet, but I keep watching videos like these that talk about the levels and their possible meaning. I truly hope I just have an infection and will bounce back. I’m still waiting for a call to make an appointment. I’m getting a little antsy.

Incredible way of teaching.. You're a lifesaver bruh♥️

very nice lecture simplified easy for internal exam and board exam , you will not concentration for a moment.Thanks alot

You are so great ! Excellent presentation and very simple😍❤️

you are doing a good job. God bless you

thank you sooooo much medicos. god bless you

How do you manage to teach these topics sooooo well when you're not a doc?!!!!!😭😭

I like how you incorporated Hme/Onc with Ethics. Good job!

I am creating a nursing case study question set for RN's preparing for NCLEX-RN and loved your RDW videa as well as the ALL video (also, I am mom to a person with Down syndrome). Can you share a common value of RDW% for a T21 patient with ALL RDW%? I cannot find an actual example value online anywhere for my made up lab report

I really appreciate ur channel existence on RU-vid 🥺❤️ Thank u alot

thank you for the video , i have a question that I don’t know how to answer can you please help me with this (how to calculate vincristine dose for a 3 yo boy who weighted 14 kg and the dose is 1.5mg/m2

Oh my Allah... i can't stop laughing each time i watch your videos: Dr medicosis: ok! If you didn't watch my previous videos, your chance to understand this topic i ZERO! 😂😂😂

Best medical channel I have ever seen.

How do I watch the videos in sequence. How can I get that outline so I follow them topic after topic

Awesome!!!! Dude where was ur channel all these years.

Well explained topics.Ater watchings these, I can easily remember difficult concepts. Thanks for uploading these videos.😊

you are just perfect!

I love you man, you compare and contrast and that's exactly what we need in medicine so much to know so confusing. Philadelphia has always gotten me before but never anymore.

I can't believe you're not a doctor, you know so much that you're basically a doctor. It's a shame you don't treat patients, you would be the best.

thank you so much youre the best

A 46-year-old female patient presented with nose bleeding, she had pallor but no icterus or cyanosis, spleen was enlarged 1 cm below the right costal margin and there was mild hepatomegaly. CBC: WBC - 124,2 х 109/L, Band Neutrophils - 5 %, Segmented Neutrophils - 15 %, Monocytes - 10 %, Eosinophils - 0 %, Basophils - 0 %, Lymphocytes - 5 %, Blasts 65 %. Since they don't mention what kind of blasts there are, what other ways are there to differentiate between ALL and AML?

thank you so much your videos ate amazing

Obtain a curte order is it standard in All countries? Or only USA??

U man just nailed All special pathology Every lecture is awesome...i luv u yrr

Please, what does it mean when you say WBCs in leukaemia investigation are less than 10,000 or greater than 100,000 but in questions you said 50,000 means leukaemia? I didn’t catch it.

Just who dares to dislike these videos !?😤

you’re my superman .. thank you so much forever

I went here to understand, why it's hard to get cured of this disease. My family is heartbroken because my older sister's nephew died the other day because of this type of leukemia. I just hope that scientists may find other treatments that have promising results especially when chemo drugs stop working.

Thank you very much Dude.

Awesome..best of its kind! Make more videos please!

Thank you very much sir. my teacher ileen😂 watches your video's .No more headaches. Var caught

Thank you...for nice explanation....

In the 2nd case the 21 yr old guy, why should it be ALL? Why not AML or chronic leukemia? Just wondering

You are a lifesaver🥺

My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.

Hi just a quick question, can a patient be in "remission of leukemia" but actually still have it? (15 y/o male with down syndrome ALL), thank you!.

OKAY SO, I have a presentation on this and I wanted to confirm a piece of information with you. So there is the type of classification which divides ALL according to morphology, immunology and genetics (which I want to assume is the same as cytogenetic, correct me if I am wrong). And then there is the classification depending on which lymphocyte precursor is being affected, whether that be the T or B lymphocyte. Anyways, I was planning on using the classification based on morphology etc and briefly (in the introduction) speak about the genetics regarding ALL; however, I was planning on mostly speaking about the gene translocation on chromosome t(9:22) and t(12:21) and rather just presenting the other types of mutations. Anyways, could you please tell me if I have understood correctly all this info? And do you agree that I should talk more in depth about the classification I told you about. Bear with me, I know it is a long post but hopefully I have expressed myself correctly (english is not my first language).

Amazing job very useful keep it up

Why would there be a mass in T - ALL. Lemonade -> lemon transformation?

ALL level 3 survivor here. Nice explanation.

I have a question if i made a bone marrow test and the result was 0.001 leukimia blood left in my bone marrow then how much time do i need for treatment and taking chemo

iv been through the whole set of videos and now have a great understanding of hematology. Thanks alot for the great videos. could you pls explain what u mean by WBC being 100,000. But the question in the video says 50,000?

Why are the platelets increasing ?

ALL is the most common cancer in pediatrics, but in Down syndrome patients AML M7 is most frequent.

Thank you so much very amazing.

hey can you post more vidoes for WBC?

Thank you so much

Thanks...

how is he not a doctor he is smarter then my profs

The questions at the end😍😍😍. Thank u sooo much

Wowwww! Love from India! :)

Thank you so much for your videos. You made most of your discussions seem like a walk to the park compared to the books that I've been reading for hours and made me feel like I'm being punished in hell lol

ok what do you mean by mucosal bleeding? Pictures make me think it's petechiae but it's not, right?

itz a completely curable one??

Thank you for the effort and time you spent to give us this knowledge ❤️

Can you add coagulation cascade? I can't find anything yet. thank you! By the way I love your videos, they are amazing.

Thank u so much sir..i can understand clearly each n every point😊but i have 1 doubt sir..u told ALL occurs in less than 14yrs..but in the last question 21yr old male had ALL...i am little bit confused sir

amazing video as always ❤

Awesome work👍

Leukemia 💯 well understood because of you🔥

You have no idea how nice it is to be taught by someone who has a sense of humour and has a genuine interest in the topic. Thank you Mr Perfectionalis 🫡

Thank u so much

Thnx alot

In all these leukaemia, Reference range for WBC is 10k to 100k. Can you explain why is it so wide- range ?

Thank you. Thank you, Thank you .... ❤❤

What TDT Means?

Thank you for posting this video, it was so helpful!! But it is TdT not tDt

My son is battling leukemia at this very moment, it is shown in our channel

You are the best 💖

Nice explanation

Wait... you're not a doctor?! Wow yet your medical knowledge is so amazing!! May I ask what is your profession?

At the minute 7:00 I think CD20 positive in pre-B ALL is a mistake, since CD20 is a B mature cell marker. Could you let me know if it is so? Loving your videos, greetings from Rome.

Please my brother , can I find your videos or your words in the videos as PDF ? 🖤🖤

Thank you so much ❣️lots of love from nepa