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Adrenergic Receptors: Types, Distribution, Mechanism, Agonist, Antagonist 

Nonstop Neuron
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Adrenergic Receptors:
Adrenergic receptors are G protein-coupled receptors. Broadly they are divided into α, and β adrenergic receptors. α1 receptors are involved in vasoconstriction, contraction of smooth muscles in the genitourinary tract, glandular secretion, and gut relaxation. α2 receptors are involved in the inhibition of neurotransmitter release from nerve endings, decrease in sympathetic outflow, inhibition of insulin release, platelet aggregation, and vasoconstriction. β1 receptors are involved in the stimulation of heart activity, and the release of renin from JG cells in the kidney. β2 receptors cause bronchodilatation, vasodilatation, uterine relaxation, relaxation of the digestive tract, detrusor relaxation, and increased aqueous secretion.
Dr Vipul Navadiya
Chapters:
00:00 Title
00:04 Introduction and Types
00:43 Alpha-1 Adrenergic Receptors
01:51 Alpha-2 Adrenergic Receptors
03:18 Beta Adrenergic Receptors Introduction
03:37 Beta-1 Adrenergic Receptors
04:25 Beta-2 Adrenergic Receptors
05:19 Beta-3 Adrenergic Receptors
05:49 Summary
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.

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1 июл 2024

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Комментарии : 40   
@1Itsyasr
@1Itsyasr Год назад
Thank you so much for the video and amazing free notes 😊♥️
@yevgenympinyuri6983
@yevgenympinyuri6983 9 месяцев назад
your content is really helping me to a greater extent, thank you so much
@treystills
@treystills Год назад
6:44 bronchodilation. Thank you for this vid. Very helpful!
@mclingwall9
@mclingwall9 Год назад
extremely helpful! thank you!
@haroldtheopolis3002
@haroldtheopolis3002 Год назад
Thank you Brother
@kaimingraymondhung6495
@kaimingraymondhung6495 Год назад
Thank you so much for the amazing video
@user-zq3vv6nt8k
@user-zq3vv6nt8k 6 месяцев назад
Thank you so much
@mrmc55
@mrmc55 11 месяцев назад
Thank you ...❤❤
@rjma89
@rjma89 Год назад
Thanks a lot!
@syedzahidalishah1184
@syedzahidalishah1184 Год назад
Thank you soo much Bundles of info in short time Great videos and explanation
@NonstopNeuron
@NonstopNeuron Год назад
Most welcome
@BdTopVariety.
@BdTopVariety. 9 месяцев назад
thanks.
@m_m786
@m_m786 Год назад
Nice 👍
@user-op7ic5cy7q
@user-op7ic5cy7q Год назад
~ alph2 dosn't cause "blood vesseles constriction " in activation , they are cause B.Vs dilatation , so use in pregnancy HTN .
@angry_moose94
@angry_moose94 Год назад
How come? Alpha2 are Gi-coupled. Activation of Gi receptors causes inhibition of Adenylyl cyclase which in turn causes low levels of CAMP that is needed to activate PKA. This results in lower levels of phosphorylated (activated) PKA. Low levels of phosphorylated PKA results higher levels of unphosphorylated (activated) MLCK which is necessary for sm contraction. Therefore, Gi causes vasoconstriction as far as I understand it.
@angry_moose94
@angry_moose94 Год назад
Alpha2 agonists used to treat hypertension include methyldopa. The way it causes vasodilation is by acting on the nervous system and reducing sympathetic tone. This results in less catecholamines being released and thus less a1 activation in blood vessels => vasodilation. But as I said, when it comes to a2 receptors on blood vessels, they cause vasoconstriction.
@velunataraj7433
@velunataraj7433 Год назад
@@angry_moose94 good explanation
@dr.akhter-uz-zamansumon3321
Good
@sairaahsan9019
@sairaahsan9019 Год назад
It's amazing video but I have a question that adrenergic agonist inhibit or prevent digestion so, why they increase glandular secretion?
@NonstopNeuron
@NonstopNeuron Год назад
Sweat gland secretions are increased at certain locations(α1 action). Secretions in digestive tract are generally inhibited (α2 action).
@Givozambia
@Givozambia 7 месяцев назад
6:44 brochoconstriction?
@user-ve5ej9xh2i
@user-ve5ej9xh2i 6 месяцев назад
Sir, I can not download pdf?
@aliibrahem9283
@aliibrahem9283 8 месяцев назад
I cant dowenloed the notice. Can help me 😢
@MNJ0202
@MNJ0202 Год назад
6:40 bronchodilation
@NonstopNeuron
@NonstopNeuron Год назад
Ohh yes.
@nal-awad7963
@nal-awad7963 Год назад
Can anyone help me understand a couple things I still can't wrap my head around? Why do Alpha 1 receptors oppose bladder voiding? I thought contraction in the bladder meant urination.. Also, how/why is Propanolol a B2 antagonist?? I thought it would promote relaxation since it slows heart rate. Thanks to anyone that can help!!
@ashleyash1229
@ashleyash1229 Год назад
because adrenergenic receptors are in sympthetic nervous system and are activated during fight and flight condition and alpha 1 are excitatory and causes the contraction of trigone which we can say causes the internal sphinctor muscles to contract as well .as a result urie is retained in the bladder and process of urination is inhibited. for urine to move out of the bladder the iternal sphinctor muscles are supposed to be relaxed.i hope it really helps . english is not my first language so if you find any mistake in my explanation please just forget it
@xiaoling4320
@xiaoling4320 Год назад
ninja nerd said Alpha 1 receptor aren't really found on the smooth muscle of bladder wall, just the sphincter muscle of the bladder
@laraibbalooch8934
@laraibbalooch8934 Год назад
Yesss cause it causes contractions of sphincters so if they get squeezed urination will inhibit
@ska4666
@ska4666 Год назад
propranolol is a nonselective ß blocker so it blocks all ß2 receptors as well, hence antagonistic action; and ß2 has similar action as ß1, in Heart (i.e., ↑H.R. , ↑Contractility , ↑No. of signals from S.A. to A.V.)
@DhirajPatil-tz9sl
@DhirajPatil-tz9sl 9 месяцев назад
if clonidine does vasocontriction how it lower the blood pressure
@madan7246
@madan7246 8 месяцев назад
Clonidine decreases the release of neurotransmitter (nor - epinephrine) , you can see in 1st point
@montazaraldujeili2475
@montazaraldujeili2475 Год назад
💪🏻💪🏻💪🏻
@ComPasPharm
@ComPasPharm 9 месяцев назад
The information is wrong. Alpha 1 cause contraction of bladder (relaxation of the detrussor is under beta2) and there is no alpha 1 in the gi tract(also under beta2). Also no information on adrenergic receptors on the iris muscle.
@letscrackcee18
@letscrackcee18 6 месяцев назад
Brother there is alpha 1 in GIT ,too
@ComPasPharm
@ComPasPharm 6 месяцев назад
​@@letscrackcee18 There are... but in sphincters... causing sphincter contraction. Alpha 1 receptor stimulation cannot cause GUT relaxaxion, as is told in the lecture. So GUT relaxation, in some way is provoked by the adrenergic but by beta2 receptors not by alpha1.
@rinaislam6428
@rinaislam6428 11 месяцев назад
❤❤❤❤❤
@rjma89
@rjma89 Год назад
Your logo looks like Rick is running
@NonstopNeuron
@NonstopNeuron Год назад
Point 😅
@likebutterfly3082
@likebutterfly3082 Год назад
🤩🤩😍😍😍👏👏🥇💯💯💯💯💯
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