Despite all the sadness and disappointment regarding his misdeeds I can't resist saying the guy is talented in conveying interesting content in such a captivating way that he keeps me watching
Dude, THANK YOU. This is a great explanation! But also, the AlphaFold code available says it can't be used to predict structures outside of the CASP13 dataset. Does this mean you actually can't input your own sequence of interest, or just that accuracy cannot be ensured with other sequences?
Siraj, we cannot use our own sequence to predict the structures using AlphaFold, as per the GitHub website data and the alphafold website. So, how you did it?
Watching this as a 50 year old GenXer...confirms that I totally dont give a fuck that young people didn't learn cursive. Ya'll know code. And code jargon. Communication tools orders of magnitude more powerful.
This is a huge breakthrough in biology. But saying that it will replace biochemists is like saying that a stat. analysis software will replace mathematicians. AI will play a huge role in future scientific research but that doesn’t mean that it will make biochemists useless.
Can you use this code to predict new protein structures? Where do you put the file with the sequence you want to predicted? Can you visualize using PyMOL?
(alphafold_venv) (base) jisna@ccc-CELSIUS-W570power:~$ pip install -r alphafold_casp13/requirements.txt Could not open requirements file: [Errno 2] No such file or directory: 'alphafold_casp13/requirements.txt' I am getting this error..
what if you accepted you don't know machine learning and AI you talk so much about. Go on to take a break and then coming back after a year or so with strong knowledge of concepts. just a recommend though i know u r a RU-vidr and not a AI teacher in any way.
Hey Siraj, can you make a video on the Bayesian neural network? it's a very underrated topic in the field of machine learning but I feel like the intersection of the graphical model, neural network and Bayesian statistics will the next breakthrough
Hii Siraj, recently i am checking your video to understand about #auto image captioning and i am not able to found any video on this topic so if you are able to make video in this topic that will be great. BY the way loves video
Knock knock Whose there? I am the Protein folding problem, cause it's still not solved. Mind the difference between structure prediction and structure determination.
Sorry, but the original Alphafold implementation is a dead-end. Some others were made: 1- ProSPr (github.com/dellacortelab/prospr) 2- Alphafold_pytorch (github.com/Urinx/alphafold_pytorch) A paper on the first is in bioRxiv since November. I would rather focus on this one.
Siraj, there's a Git Issue that may help categorize which of your repositories can be fixed automatically and which that will require human intervention... github.com/git-utilities/fix_logs/issues/1#issuecomment-579574567 ... the default `config.json` has also been updated with those repositories that are easiest to fix via script. Let me know if questions on resolving merge conflicts arise and I'll try to make some time for you.
@@SirajRaval, indeed I see that you have made that choice, as well as other choices. Hopefully you'll be able to make use of the project to fix some of your repositories. Feel free to keep an open line of communication (eg. open an Issue if problems arise), and I'll be happy to help problem solve with you.
They've not solved it, at CASP they correctly predicted 25 out of 43, and also they don't really know what's going on. They are just using similar structures to predict.
Can que simulate simple cells? If yes, can we simulate simple multicelular organisms like a worm? If yes can we simulate complex multicellular organism like a fish and it's brain? Or a human brain?????
@@SirajRaval we are all made of cells right? So when it happens we would be able to simulate a entire human being and discover the secrets of the brain and Biological inteligence???
Dev do futuro , seems like it should be that simple, right? I learned how to cook an egg, now I know how to cook all dishes that contain eggs, I learned how to hold, tune, and pluck a guitar, hold on to your face Eddie Van Halen, I’m gonna out-shred you tomorrow. Weirdly, we can’t yet jump from fundamental principles to mastery that quickly, but soon Alpha-universe will. If a step takes a month, and it takes 50 exponential steps to get to 100 trillion, we should be on track to get to human intelligence this decade and all intelligence in 25 years, but not tomorrow or even in the first quarter of this amazing year.
