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Alternative Splicing 

Biology Professor
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Biology Professor (Twitter: @DrWhitneyHolden) teaches a lesson about alternative splicing, the highly regulated process in eukaryotic cells that allows one gene to code for multiple proteins, with a focus on the diversity this brings to the genome and on the mechanism of alternative splicing, including the spliceosome

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4 авг 2024

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Комментарии : 110   
@betulkayitmazbatir7022
@betulkayitmazbatir7022 6 лет назад
That was a very clear, helpful and useful lecture. Thanks a lot from Turkey!
@BiologyProfessor
@BiologyProfessor 6 лет назад
You are very welcome!
@ryanally2616
@ryanally2616 6 лет назад
Beautifully explained and illustrated keep up that great work! Thank you for your time!
@abumonsurdinar
@abumonsurdinar 4 года назад
Best faculty I ever found to make things easy. Thanks!
@selenc.3324
@selenc.3324 4 года назад
I also was shocked when I first read about alternative splicing. This is an amazing mechanism
@antonioschannel1714
@antonioschannel1714 6 лет назад
Very good and simple explanation. Greetings from Germany
@excellentsimplified4655
@excellentsimplified4655 2 месяца назад
Yeah
@celiagomez7657
@celiagomez7657 6 лет назад
Nice video! It is the first one I've found that explains the regulatory mechanism, and not only what it is alternative splicing. Thank you :)
@excellentsimplified4655
@excellentsimplified4655 2 месяца назад
Yea
@kanishkjha7621
@kanishkjha7621 3 года назад
Lecture was amazing, thank you for making it simple to understand.
@TheDanyalahmad
@TheDanyalahmad 6 лет назад
that was so helpful thank you from Canada!
@eduardobagagli5898
@eduardobagagli5898 5 лет назад
Thanks for the class. Great.
@felipesegatodezem1340
@felipesegatodezem1340 6 лет назад
Very helpful indeed. Thanks from Brazil!
@hassananjum3782
@hassananjum3782 4 года назад
This was so simple and informative!
@user-jr1fx3vw2n
@user-jr1fx3vw2n 6 лет назад
Lecture is well made. Thanks a lot!!
@debojitmahato6677
@debojitmahato6677 2 года назад
Thank u miss, Ur all videos are really simple explained and helps a lot in my studies☺️❤️💕
@heyahowareyou5971
@heyahowareyou5971 Год назад
Thank you for such a clear explanation, helped me a lot. ❤
@giselecampos5954
@giselecampos5954 3 года назад
Super helpful and clear, thanks!
@amit523
@amit523 Год назад
It was a great video and very good information. Thank you.
@daviddesaur8570
@daviddesaur8570 5 лет назад
Very helpful, thank you!
@peartht4539
@peartht4539 5 лет назад
Thank you very much great explaination make the topic very interesting thank you
@mayajager2810
@mayajager2810 4 года назад
omg this helped me so much!! amazing video
@dradelaguirgis4644
@dradelaguirgis4644 Год назад
This is very much appreciated, thank you. Adel from Egypt.
@kirstenholder7270
@kirstenholder7270 4 года назад
This is so helpful, thank you
@carvonekang7843
@carvonekang7843 6 лет назад
excellent video!
@megangilchrist315
@megangilchrist315 6 лет назад
great video! thank you!
@ellygreening5616
@ellygreening5616 3 года назад
concise n helpful, thanks a bunch
@carstennick6430
@carstennick6430 5 лет назад
Very helpful! Greetings from Germany
@itsdwish
@itsdwish 6 лет назад
That was helpful, thanks!
@korenpolak
@korenpolak 6 лет назад
very good explaind ! Thanks
@hamidgaikani9683
@hamidgaikani9683 4 года назад
Awesome. Thank you very much!
@treznorwood5834
@treznorwood5834 5 лет назад
I LOVE THIS WOMAN! THANK YOU! life saver!
@bakhtawarkhan9547
@bakhtawarkhan9547 5 лет назад
Thank you very much mam
@samuelmartinezalcala2441
@samuelmartinezalcala2441 3 года назад
Thank you. Very helpful.
@boaz08995
@boaz08995 5 лет назад
thank you very much that was a great video!
@ptilongmarchimrankhan3678
@ptilongmarchimrankhan3678 5 лет назад
Very helpful .... love you Mam..
@okikeokon6806
@okikeokon6806 5 лет назад
Thank you so much 💓 too helpful
@shahinimran5291
@shahinimran5291 4 года назад
Nice explanation. Greetings from Japan.
@brilliantfuture1841
@brilliantfuture1841 2 года назад
Your explanation was fabulous ♥️❤️ Thank you very much 🙏🏻👍🏻🌹
@BiologyProfessor
@BiologyProfessor 2 года назад
You're welcome 😊
@umairsherpao3594
@umairsherpao3594 3 года назад
Excellent..
@sabrinatherican7742
@sabrinatherican7742 5 месяцев назад
Very good!
@prabinghimire1865
@prabinghimire1865 2 года назад
nice explanation mam...love from india
@pagent666
@pagent666 4 года назад
Thank you for such clear explanation of such complex process. 95% of the genes are alternatively spliced -- that is a shocking and very useful information.
@wenjunyang2585
@wenjunyang2585 6 лет назад
very helpful!
@Ray-jg1bw
@Ray-jg1bw 6 лет назад
Thank you, great lecture!
@mortadhamohammad7940
@mortadhamohammad7940 5 лет назад
Thank you thank you you saved me
@isurithakshila516
@isurithakshila516 5 лет назад
Very helpful thnkuu😍
@user-ti2ph6qb1y
@user-ti2ph6qb1y 5 лет назад
thanks!
@gulkhan00007
@gulkhan00007 3 года назад
Very good explanation, Greetings from Kashmir
@BiologyProfessor
@BiologyProfessor 3 года назад
Thank you very much!
@sarahbrandao6028
@sarahbrandao6028 Год назад
What about alfa-tropomiosyne? Is there any difference in the splicing process between exons 2 and 3 and 7 and 8?
@subhajeetray8288
@subhajeetray8288 7 месяцев назад
Can you please tell me from where You bought the non-linear slip watch. I want to buy it please ❤
@chemiflask7692
@chemiflask7692 2 года назад
Bravoo!!
@mayanksangam9205
@mayanksangam9205 2 года назад
Thank you professor :)
@BiologyProfessor
@BiologyProfessor 2 года назад
You are very welcome 🤗
@dr.ragill2752
@dr.ragill2752 3 года назад
Please also make a video lecture on the generation non-coding RNAs from TE. Thanks!
@mosara7209
@mosara7209 2 года назад
عظيمة والعظمة لله
@user-re4iv6ny1p
@user-re4iv6ny1p 2 месяца назад
Thank you so muchhhhhhhhh
@kagambodagi6239
@kagambodagi6239 4 года назад
Awesome
@maimonaweisy
@maimonaweisy 4 года назад
you'er the best
@Raichu1393
@Raichu1393 5 лет назад
Hi professor! I found your video helpful but I do have a question. If alternative splicing gives different sequences how can that be a good thing? I understand that it does bring up diversity but isn't the whole point of making the RNA in the first place to have the code to make specific proteins? How can alternative splicing be helpful when it codes for different proteins? Isn't this close to a mutation? I am just confused about this being a good thing. Thank you for your time!
@BiologyProfessor
@BiologyProfessor 5 лет назад
Hi there! It can be a good thing because it can result in more than one functional protein. Via alternative splicing, it is possible to make different proteins that are similar enough that they carry out related functions that are just a little different from each other. For example, the Drosophila Down syndrome cell adhesion molecule (Dscam) gene has 95 exons. Drosophila can make 38,016 different isoforms by the alternative splicing of these exons. These different isoforms will all have slightly different activity in the cell. That is a lot of variety! You can see some more examples here: en.wikipedia.org/wiki/Alternative_splicing#Examples
@Raichu1393
@Raichu1393 5 лет назад
Thank you!
@onurulusoy7613
@onurulusoy7613 2 года назад
god is a great engineer
@Miaumiaupachamama
@Miaumiaupachamama 3 года назад
Very good explanation, thank you Greetings from Perú
@BiologyProfessor
@BiologyProfessor 3 года назад
My best friend’s husband is from Peru. Greetings back to you. :)
@Miaumiaupachamama
@Miaumiaupachamama 3 года назад
@@BiologyProfessor nice!! tell him "que chevere" :D
@MegaClaymore123
@MegaClaymore123 5 лет назад
Thank you very much! You look like emilia Clarke by the way
@sumitkumar-el3kc
@sumitkumar-el3kc 3 года назад
Is it possible to have 2 or more transcripts for different proteins simultaneously from a single gene?
@BiologyProfessor
@BiologyProfessor 2 года назад
Yes, multiple RNA transcripts can be made from a gene and exist simultaneously in the cell, with some being spliced one way and others being spliced a different way.
@David-vu1xq
@David-vu1xq 5 лет назад
I just want to learn about splice donor/acceptor sites and where they can be found!
@arunkaushik2121
@arunkaushik2121 2 года назад
Love From India 🇮🇳
@milagrosavalos9675
@milagrosavalos9675 3 года назад
What can be removed from pre-mRNA during alternative splicing?
@BiologyProfessor
@BiologyProfessor 2 года назад
introns are spliced out, and sometimes part or all of certain exons that would be left in the mRNA in alternative forms.
@MrBeer-cg5oi
@MrBeer-cg5oi 3 года назад
Good videos
@BiologyProfessor
@BiologyProfessor 3 года назад
Thanks! 😀
@leminh8159
@leminh8159 4 года назад
Does alternative splicing create genetic variation and evolution?
@BiologyProfessor
@BiologyProfessor 4 года назад
Yes! It doesn’t alter genes directly, but Alter’d their expression, which creates differences that can be acted on by natural selection. More here: news.mit.edu/2012/rna-splicing-species-difference-1220
@elijumalon6125
@elijumalon6125 5 лет назад
What's the importance of Alternative Splicing?
@BiologyProfessor
@BiologyProfessor 5 лет назад
Alternative splicing allows eukaryotic cells (including human cells) to use the same GENE to get more than one PROTEIN, just based on which exons are kept in the mature mRNA transcript and why are spliced out. In other words, there can be multiple similar/related proteins possible from one gene.
@elijumalon6125
@elijumalon6125 5 лет назад
Thank you! 😄
@AndreasSippus
@AndreasSippus 6 лет назад
Please invest in a wearable microphone. Otherwise really good video! Also good with the short selected theory on the left side of the board. Thanks again!
@dr.ragill2752
@dr.ragill2752 3 года назад
Thank you for explaining AS generation mechanism in a good and simple way. I am also looking for the AS analysis pipeline using the Linux platform.
@BiologyProfessor
@BiologyProfessor 3 года назад
I’m sorry, I don’t know much about Linux. I used Unix for a semester in college, but I’ve forgotten it all. :(
@powerispower3173
@powerispower3173 3 года назад
please made assignment on Differential RNA Processing
@BiologyProfessor
@BiologyProfessor 2 года назад
Differential RNA Processing is another name for Alternative Splicing.
@gabrielcodina5466
@gabrielcodina5466 4 года назад
Alternative splicing=gene expression regulation?
@BiologyProfessor
@BiologyProfessor 4 года назад
Yes, it is one form of regulation of gene expression
@eikitheterminator
@eikitheterminator 5 лет назад
Just FYI; you cannot skip the 1st or the last exon
@study_with_me55.
@study_with_me55. Год назад
Sorry but can you tell me the reason
@LeoTheLion1679
@LeoTheLion1679 4 месяца назад
A-MAZ-ING
@imankitroy5865
@imankitroy5865 3 года назад
Ma'am you look like Pam (Jenna Fischer) from The Office US
@sccm100
@sccm100 5 лет назад
Screw the lecture. Are you single
@deepakmeena-vi7fz
@deepakmeena-vi7fz 6 лет назад
M'dm u r vry beautiful along with good lecture
@bholanathchakraborty4921
@bholanathchakraborty4921 4 года назад
U teaches really well..i am become a huge fan of u..can i get ur email or number mam??..actually i want to shootout some problem related to genomics..thats why i want this.if u dont mind so could u??
@Dj-pk5mm
@Dj-pk5mm 2 года назад
You are looking alike to my gf ,Indian . 😘
@kilianwagner5643
@kilianwagner5643 4 года назад
are u sure that it is 95% of multi-exonic genes being alternatively spliced? I learned 59%
@BiologyProfessor
@BiologyProfessor 4 года назад
I got it the number from here: pubmed.ncbi.nlm.nih.gov/18978789-deep-surveying-of-alternative-splicing-complexity-in-the-human-transcriptome-by-high-throughput-sequencing/ It is from 2008, so could be out of date; but I think it is still definitely higher than 59%
@leslievlogs14
@leslievlogs14 5 лет назад
You look like emma watson
@rakshithgs4269
@rakshithgs4269 2 года назад
R u single?
@planckbohr348
@planckbohr348 3 года назад
Do you have a boyfriend?
@BiologyProfessor
@BiologyProfessor 3 года назад
No, I have a husband.
@planckbohr348
@planckbohr348 3 года назад
Biology Professor for how long 🧐?
@BiologyProfessor
@BiologyProfessor 3 года назад
Quite awhile. We’ve been together over 10 years
@planckbohr348
@planckbohr348 Год назад
@@BiologyProfessor but I want you 🥺
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