Hey, why have no hair loss channels dived into Dr. David Sinclaire and how he can reverse aging... and sometimes hints at regenerating hair loss with the same process?
My routine: • Use warmed Littlllextrra Cocooniion oil and massage scalp and secure my hair in a protective style. • I usually wake up at 8:00 am, but I wash my hair at 12:30 pm, so almost after 14 hours, I begin my washing routine. • Dampen my hair with warm water. • Apply Cocooniion shampoo two times. • Rinse out the shampoo and use plenty of hair conditioner. • After 10 minutes, rinse with cold water. • Use a microfiber cloth to towel dry. • Use a towel turban. • After 30 minutes, use a lightweight serum. • Gently detangle my hair. • Allow my hair to air dry naturally. • Tie it into a ponytail. My hair is 10 inches and I have 1b hair. I usually do this just once a week on Sundays.
I have been struggling with hair fall for a long time and used various products with little success. A pal like you told me about this cocooniion shampoo, and after sticking with it, I can see a significant difference. My hair fall has reduced a lot.
I understand you are tired, but It is great that there are companies doing actual serious research regarding hairloss. The last 2 years alone, we have seen so many new startups and many new drugs have proceeded through the clinical trials. There is progress. Pyrilutamide for instance, is the first anti-androgen since finasteride reaching the phase 3 trial. This was already 12 months ago. For sure we will have some new options soon.
@@joshvandamme5080 I like the way you think about companies putting effort. Also, I’m convinced after reading and personally trying that’s all these new anti-androgens are gonna be weaker than Dut and Fin. All in all as OP says, for now and for almost half a decade all we have is Finasteride and Minoxidil (not everyone knows dutasteride).
@@iambrucesz --Very possible that they will be weaker (although the data of the phase 2 trials do suggest that pyrilutamide might outperform finasteride on some metrics, but we have to wait and see). However, having a topical anti-androgen that is FDA approved will be amazing. First of all, they can be stacked with existing treatments and they might prove to have a better safety profile. But yes, the desperate sentiment is very understandable and people's patience really get tested.
Hi. I am a doctor from St. Petersburg. Ph.D. I have had two hair transplants. I believe that there are three options for promising directions for bald people: 1) cloning of hair follicles. 2) blocking receptors sensitive to dihydrotestosterone; and 3) CRISPR-Cas9 genome editing technology, which allows you to cut out the genes responsible for baldness.
GT20029 is much more promising than Pyrilutamide. And by far actually ! Hope GT20029 gets FDA approved as soon as possible 🙏. Edit : very well explained video by the way ! 👍
The problem is that every topical treatment also goes systemic. What we really need is a way to specifically target certain tissues/enzimes/etc without affecting anything else. Maybe crisper technology could help with this I don't know but until then every treatment will fail to surpass what we already have now.
Not really, topical treatments stay locally and an incredible small amount goes systemic, this is why it's much safer than treatments that are absorbed through the stomach which will spread the medicine through your entire body
CRISPR is difficult because current gene therapy research is a) far more focused on serious medical genetic diseases and b) is littered with problems such as increased risk of cancer-post usage, unexpected immune responses, etc. I think there is hope in the future, but not within our timeline. Science is thankfully, and unfortunately, a slow and measured process.
@@simonecusumano3170 and drink water..NO SODA..and red light therapy and masage your head twice a week..ive been on the minoxidil pill for a about 5 months..its so much better then rogaine twice a day..i use the rogaine once every 3 days..my hair has grown alot..im also on finateride, fo ti, biotin and l tyrosine...and if u smoke, you better stop
Approximately 2.06 billion men aged 18 and older could potentially suffer from androgenic alopecia, given the known rates of prevalence. It's puzzling why there isn't a dedicated bro' fund for researching hair loss remedies.
Well let’s hope systemic concentrations at or below 0.001 ng/ml are not harmful. This drugs mechanism of action sounds like it has the potential to produce far worse side effects than finasteride. Destroying androgen receptors, yikes.
Ubiquitin tagging is a common degradation pathway within cells, this is very interesting, if the effect can be localised by topical administration then excellent.
Matt, you can judge me but I manipulated a sildenafil(viagra) topical solution of 2% and I’m applying together with minoxidil. It is working I can guarantee this, I can see more volume and thicker hair
@@alexmusaddique_7864 idk, I can imagine that the sildenafil, being a vasodilator, might increase bloodflow to his scalp and help out them poor hair follicles. But Victor, you're rubbin viagra into your scalp, are you walking around with a half chub?
that's because the hair loss research industry has sadly been lacking behind other industries, even cancer.. It has only recently been starting to get more funding and research being done since the last 8-10 years. Finasteride/Propecia and Minoxidil were all we had because Pfizer & Merck were satisfied with them enough, they weren't doing more research, but people got fed up and smaller biotechs started doing more research on it and then some bigger firms got more interested after seeing that smaller companies were racing to get a piece of this pie and they with all their resources were ignoring it. Also, academic research has led to smaller breakthroughs, little discoveries that has led to more money being poured in due to increased interest. Also, more discoveries started being made by labs all around the world, even some that weren't intending to study anything related to MPB or alopecia they were doing reserach for other indications/diseases and they stumbled upon discoveries that could potentially be translated to alopecia research. I think the hard work and investment is starting to pay off, there has never been so many different players in this market, we are so fortunate , better treatments and even a cure could come sooner since the research has accelerated. I am paying the closest attention to verteporfin, due to it's wound healing abilities plus follicle regeneration in every study they have conducted on pigs and mice, i know it is only pigs and mice, but a hair transplant surgeon, Doctor Baghouti has started a small human trial since mid last year, and the research is ongoing. He thinks verteporfin may have regrown 30 percent of hair after it being plucked and treated with verteporfin in the donor zone, this could potentially mean unlimited hair transplants in the future, but more studies need to be done with verteporfin to know for sure if this is not just a fluke or the real deal
Time travel for sure. We'll all have a time travel booth in all our homes AND a pill that makes us live to a minimum 130 years before ANY hair loss cure.
20mg/ml Ru58841 , fin 0.01% , minox 3% , stemox 2%, all mixed together and applying 0.75ml in the morning working well holding ground an slight thickening, no sides
Hey Matt. An idea for a video subject: Can it be ok to transplant hairs that are outside the safe donor zone? I can take myself for an exemple: -M28, strong temple/hairline recession with overall diffuse tining on the top. -Got 3500 graft one year ago on the first half and the hairline. Great results. -My donor is average, and I have thin hair. I might have 3000-3500 grafts left at best in the safe donor zone, and even if it's well done, it's going to be very scattered if I extract that much. Looking at my mother's father (the only one in the close family that had MPB, and I'm following the exact same norwood pathway), he ended norwood 5 /5a at nearly 60 (before he died) even tough he was already norwood 4 in his late twenties. He NEVER lost the hairs at the top of the sides, they were very thick and dense (big contrast with the void a few centimeters higher, on the top of the head). So the question is: if there is a lot of chances that your MPB isn't going to end in an norwood 6 or 7 (family observation, being on medication..), is it an option to extract hairs outside the safe donor zone, and mix them with hairs from the safe donor zone, to increase the amount of grafts you can implant? Thanks for ur work mate!
Grafts taken from unsafe donor zone are being utilized as last reserve in case you have already had multiple transplants and no more grafts can be taken from the safe zones. Ideally these hairs should be placed in the mid-scalp and crown areas just in case that they will not become as permanent in the future. Medication will be a deciding factor here in my opinion. If you are taking finasteride + minoxidil or dutasteride + minoxidil after hair transplant, I think you are able to make this hair ''more permanent''. If you are not on medication, I don't think so.
Nobody loses hairs from the back of their head. So, those are used for transplant to avoid future losses. Practically any hair from any part of your body can be transplanted, even your armpit hairs. But, if "Your" gene have a tendency of losing armpit hair. Then that armpit hair wherever it gets transplanted doesn't matter. It will die too.
I'm still not convinced DHT is soley to blame for MPB. If hair loss on the top of the head is due to sensitivity to DHT then why does the hair fall out in a predictable pattern? All the hair on the top of the head is in the area where hair loss occurs so why then if it's all sensitive to DHT does it not all fall out at the same time at the same rate? We still need to figure that piece of the puzzle out.
@@ayadhussin6771 it appears like it's some kind of programming. Obviously the entire top of the head is DHT sensitive so why wouldn't it all start falling out at once at the same time? But it always starts at the front and temples and works it way back while the crown area then also starts balding. It's almost like nature wants you to slowly get used to the fact you will be without hair. Or falls out the same way it grew in. There's some kind of hidden order
@@kennyofatoboiyo7447 Then how do you explain about 1mg oral finasteride tablet that successfully helped many milion of men against their programming hairloss (androgenetic alopecia)?
@@ayadhussin6771 because it's still partly due to DHT. But it will not regrow your frontal hairline ever. Mostly if just slows down the rate of hairloss not completely stop it eventually over decades you still lose some hair because of some kind of programming or the fact Finasteride can't block all DHT. The fact it falls out in a pattern proves some kind of programming is going in as all the hair ok the top of the head can and will fall out and yet does so in stages
@@kennyofatoboiyo7447 the root is of course genetics that cause such an odd sensitivity to dht, thus the perfect solution is gene editing, and removing the bald gene completely.
Great video. I have to ask (related to a previous video) , did your back pain come back after returning to finasteride. I think I'm having the same issue. Back pain in fin on none when off fin
Hi Matt, love your content is gold! i wanted to ask. i have chronic itchy scalp because of skin condition( seburrehic dermatitis) if you can make a video for a inner solutions for hair loss i'll be very thankfull 🙏
@@letsgethair not topical on the scalp. Oral medications or temporary treatment like PRP. Because derma rolling or minoxidil or ant kind of topical thing make my scalp condition worse. Thanks a lot 🙏
@@laptopstudy3279 So you say carbs from wheat can trigger baldness for people who are predisposed to genetic hairloss? Sounds logical because diet have huge impact on hair health but also stress level
Crazy to think that we might find the "cure" to balding in the upcoming decades, by that I mean reliable long-lasting solutions that don't require daily application of medicine for the rest of your life.
Now,I ,with grade-3.5 baldness recently started finesteride and hope it will be effective upto 10 years and then,I will dutasteride to it and hope ,this too will effective upto atleast 5 years ;then ,I will undergo PRP and hope this will be effective upto atleast 5 years ;then I will undergo FUT hair transplant and this will definately upto 10 years .So ,I hope that this comes in the market atleast in 30 years before I will run out of each and every options avaiable at present
I personally think this is a myth. Note the example of the bald man that was burned on the scalp and his hair grew back. Also hairs grow from nowhere on the entire body and people who go through traumatic circumstances like cancer can start with red curly hair and their hair will complete change to blonde straight hair afterward. We know very little about this.
Hey Bro hope your doing well. I am 19 years old and been on Finasteride for 2 years. I want to know does it effect facial hair and is it possible that it effected growth during those 2 years i was on it. Keep on with the amazing content really appreciate what you do brother!!!💪
Eggs ,dairy fish caused my hair loss . When i dont eat those thn i font see no hair falling out...i did tbis eating not eating weeks on weeks off n there is no loose hairs when i dont eat those foods..looking up hair loss causing foods
But ummmm, the real question here is how is that when we are young it doesn't matter how many tons of DHT or whatever is, our body can take care of it and our hair is shinny and strong but as soon as we get old our hair become shit, we have to figure out what is the elements that decrese as age that get the dht and others that kills our hair follicles
Not going to block your DHT as you think. Use Finasteride. But I think that using a shampoo is important because otherwise hair can get oily and greasy, or lose volume (if you have thin hair like mine). The additional ingredient ketoconazole 1% in this hampoo can make you 5% more successful in managing your hair loss long term, but let's not over exaggerate the importance of shampoos.
I have scaring alopecia and look like dr phil. I Desperately dream of having hair again I looked like elvis Presley with hair but now I'm just some ugly bald guy with severe depression. Went from 50 or so girlfriends in 5 years to none at all in 10 years I never leave the house anymore get everything delivered and pay bills online I just want one woman and settle down but I'm fucked I have/a gun its nice but has a funny taste just trying to get right with god and jesus first
Hi Matt, 10 days ago I had a hair transplant and what is wired is that I see a lot of doubles in my front line... I said very clear that I want only singles. I wrote now to clinic and they said that it looks like double but in reality one of follicles is destroy so I should think about this as single... So I understand that after shading face only one will grow back, right? but... if in every second hair follicle was destroyed it means that they also were not to precise in my procedure, right?
Breezula got stuck somehow after completing 2nd trial. The 3rd trial should have started in 2020 but because of lockdowns it has been postponed. Cassiopeia announced that because of ongoing discussions with FDA they are still unable to start the trial 3 somehow.
@@exactly1176 No drug loses efficacy. Some people also say that after a time finasteride loses efficacy. Well, thats not the case. What is working first, will work afterward. Maybe the hairloss will be more agressive. Then one has to up the dose, be it breezula, finasteride or whatever else. Or complement it with Minoxidil. Breezula and other topicals cannot regrow hairs endlessly, they will plateau and then you only use them to maintain what you have. I have been using Minox and Eucapil for 2 years now and after the initial thickening I do not regrow any hairs, I maintain them.
This gives me the "safe and effective" MRNA shot vibes, that trains your immune system to attack a virus (and also attacks your own organs like the heart - causing sudden death). And if it degrades the AR in the hair follicles, is that permanent? Because if it's permanent, does that mean that you can use it once and that's it? Why keep using it if the AR is already degraded?
GT20029 is just another androgen receptor blocker. It may have fewer side effects than other AR blockers but it is probably no more effective. We need a drug that has a different mechanism of action than androgen modulation to be truly innovative.
I’m sick of hearing all these crap. I’m tired of fda trials taking so long that by the time a result is announced half my hair has disappeared from my head. Like geez invent a stupid medicine that cures this slap headed curse
Good. How many thousands of dollars will this cost? The problem with hair loss treatments is the cost. If you want to have hair, you have to be a billionaire.
Jeff Bezos is a billionaire and he's bald af. You only have a thin strip of donor hair available that isn't enough to cover the scalp. Fin, dut, and minox is the same thing available to the poor as it is to the rich. That's all we have and an infinite amount of money will not save you.
Why would you support hair fibers if it’s not a solution to hair loss? I guess you using this platform for money. Including your one on one sessions. they are ridiculously expensive for the average person. You are not a doctor by profession so you shouldn’t charge more money than a doctor. Just my opinion
The same way I support using Minoxidil, Microneedling, Finasteride or Dry Shampoo...They are neither cures nor ultimate hair loss solutions, but contribute towards a better looking head of hair.
@MATTDOMINANCE Yeah I get what your saying... I just think fibers are to hide a problems and FDA approved medications support growth and create an environment conducive for hair growth. Anyhow 7 days post fue procedure in south africa 🇿🇦 I enjoy your content it's been very insightful, so thank you matt.
@@dougs_8862 --dude, his one-on-one consultations are much more extensive than what a doctor would ever give you. I did a 1 on 1 consultation with Matt and he saved me from going to a shitty clinic. Also, he kept in touch throughout the process. Moreover, you are overestimating what a dermatologist can do for you. They do not always know much about hair loss, let alone hair transplants. Matt on the other hand has spend years studying this AND has experience with a bad and a good hairtransplant.
@joshvandamme5080 dude, I have not mentioned a dermatologist at all?? I'm happy you got the perceived value you seeked. Oh what degree does Matt possess?
Nahh, pyralutamide it's already avaible for sail, I think kintor is really serious and working very hard. I use tho think pyralutamide was a false hope too and look to it.
It's great that they're working on a solution, but everything topical goes systemic to a certain extend, and I would not trust a new product that might screw up the androgen receptors in my brain, testicles, or muscle cells. Maybe after 5-10 years on the market and no adverse effects are detected.
