New Trends in Therapy for Androgenic Alopecia Part 1 

"New" trends in the treatment of male pattern baldness is a contradiction in terms! After minoxidil, finasteride and dutasteride, there has been no substantial medical progress in 25 years.

Thank you from the bottom of my heart for such a good, evidence-based, thorough content.

Keep it up docs we need alot more of this.

Such an underratted channel! Thank u both for simple honest answers.

Happy to see both of your together again!!! Started taking Dute with absolutely no side-effects, Again Thanks to both of you, for clearing the myths about the drug and spreading useful knowledge. Cheers!!

I topically applied minoxidil on my scalp for three years, though now take the oral form and it seems to work just as well.

Your channel is sooo helpful. I started my therapy 3 years ago just by following your advice to the T and I certainly see results. And no side effects. Thanks

As a woman , with hair loss I don’t give a flying hoot if my body is covered in hair , if it grows hair on my head I’m taking it

Started using Finasteride July 28th 2023.

Started topical minoxidil plus finasteride combination on July 18 2023… eagerly waiting for results…will update after 5months

Please, please, please, talk more about mesotherapy. I think my doctor here in South America has never done a treatment based only in the use of mesotherapy, without any oral alpha reductase blocker. She said I will be doing mesotherapy each six months, but you guys said 2 months and maybe it is because two months is the ideal frame when mesotherapy is the only technique being used as a treatment. Please, talk about this. I may suggest my doctor that I will be doing it each two months. She will agree.

Guys. There are now 3 “Minoxidil Boosters” on the market that supposedly up-regulate SULT1A1 in the ORS to improve performance for those that don’t respond. Only one of these has good science IMHO and this is now on sale in Asia (not the USA where it was developed). Also in Brazil you can buy Minoxidil Sulphate topicals directly. Btw. It’s the same enzyme in the liver, just a lot more of it. Lastly, Minox directly impacts the Androgen Receptors and effectively blockades the DHT.

🎉🎉🎉🎉🎉 Russel is back

Liked the bit about Loniten & liver

The only people I trust. 👏👏👏

Can you talk about the new Derma stamps (vs the typical derma roller and dermra pen -- like Dr. Pen)?

In part 2 please cover pyrilutamide and saw palmetto.

1mg per day finasteride 5mg oral minoxidil great combo!!

What are your thoughts on the current trend in Spain by Dr. Vaño of starting people off Dutasteride 5x Week + Dutas Mesotherapy? He's named one of the top doctors in Spain. Been watching your show for months & I've noticed you're on the other side of the spectrum, taking way less dosage & more infrequently.

When you use topical finasteride, even if you would use it on a balding area wouldn’t it penetrate the skin and ultimately reduce the DHT levels and thus work on thinning areas also? In other words, it’s simply a different delivery system to drop DHT levels? Therefore, why does it matter where it is applied on the head?

Great episode! Here in the UK I was introduced to GFC (Growth Factor Concentrate). It seems like it's a variation of PRP but some sort of growth factor activating proteins are added to the solution before injection. I was curious as to what this really is. Is it something that you doctors are familiar with but under a different name or something else. Naturally, I was curious about the effectiveness of it as well. I've heard it had better performance than regular PRP, but it might be a bit self-induced thinking. I would love to hear your thoughts on this. Thanks

Hi to both doctors- I’m really keen to get your take and opinions and the recent trials using verteporfin to help with almost eliminating scarring and possible hair regeneration providing a possibility of infinite donor area.

Hi there, love your videos! Would it be possible to get a video discussing insomnia as a side effect of Finasteride?

amazin information! I didnt get the lastpart though: Combining microneedling and Dutesteride and/or finesteride and/or minoxidil. Can u use everything / Should you use everything together?

Hi, 1. With regards to mesotherapy apart from the active ingredient dutasteride/ finasteride what should the inactive ingredients of the solution be? 2. Is there a risk of scaring? Apparently too much solution volume and incorrect inactive vehicle can cause scaring? 3. With regards to regular topical application of dutasteride/ finasteride what is the best vehicle? I have heard that it needs to be lipophilic to be properly absorbed eg liposomal or trichosol whilst alcohol penetration is very poor. Also some companies add growth factors like trichoxidil so thoughts on this would be good. Many thanks

Topical Pyrilutamide with oral fin and oral min is working well for me

Question: are there any supplements, like silica or biotin, that are actually worth taking alongside Finasteride?

Hello Doctors. Can you address the theme of an eventual relation between epilepsy treatments such as oxcarbazepine or levetiracetam and hair loss? Is there any known relation or study on this subject? Is there a need for regular blood analysis for a person who takes these drugs to make sure that they don't worsen hair loss? Thanks, and keep up the good work you're doing.

Topical finasteride solutions should be very cheap however there are few options available on the market and they are all quite expensive. Where's the best place to get topical finasteride at a reasonable price?

Can you talk more about a person’s predisposition or risk of prostate cancer with the use of drugs like finesteride/dutasteride? I don’t feel that this topic has even been touched on.

I think that changing the diet is a major factor in the use of minoxidil in as efficacy many people eat a western diet which is full of chemicals and manipulations that are initially just bad for the human body and health so may be changing the diet to a more clean and natural source for nutrition could be key in the utilization of things like minoxidil. Frankly I do notSuffer boulders but I have many friends with you and I noticed that they eat a very impure and putrid diet and they use things like minoxidil with minimal results, anyway it’s just a thought on my part I think proper nutrition things like fasting which also encourages the body to regenerates cells and mitochondria is another way to go

There’s one thing I’m unclear on regarding topical 5a-R blockers. Can they work in a localized fashion, or is it required for them to be systematically absorbed to work?

You talk about missing hair stem cells in the bald area. I thought stem cells never disappear but can be disabled.

great vid, interested to see what you guys will be talking about in part 2

Thank you Dr Russel and Dr Vikram in another episode you mentioned that a topical formulation still needs to go systemic in order to have effect. As i understand now, it is can be localised. So oral solution has no greater value?

thanks for info doc👍

What about KX-826 and Breezula and their future potential?

I have no interest in localized topical solutions. Anything that soaks my head/hair for 2 hours twice a day, prevents me from sweating for 8 hours a day, and makes my hair look nasty unless washed, is terrible. I was so excited to be put on oral, I couldn't care less if I grow back hair.

Nice info docs ❤️

Great video! Thank you! :)

What about SAW PALMETTO???

Finasteride made me depressed and impotent for 9 months 😮 i know some people even get suicidal because of this😮😮

Thanks 🙏 Good information.

10:15 People with mega-responsiveness to treatment (reddit/tressless) for a long time completely bald zone is this a fake?

How deep length should the derma roller be? What do you know about absorption into scalp for topical dutasteride? Would it be worth getting a longer dermaroller. Currently have 0.5 depth

can dutasteride make hairloss worse? i was on finasteride for 4 years with good maintenance but wanted more growth. i started dut 8 months ago and have lost a lot of density at the temples and my scalp is hurting. what should i do?

Does derma rolling create any damage on existing good hair? If no then why?

Do you know/think there will be any research into the gene that causes DHT sensitivity?

Doc, we need your opinion on emerging treatments like SCUBE3, GT20029 and Pyrilutamide

I had a hair transplant one year ago. I never had shock loss or not that much of it. So lately I have been seeing loss of hair with a small ball connected. what's going on?

Can you explain to me why do i have this Bitter taste in my mouth i applied 2ml twice a day? Anyone else experienced this?

What are your thoughts on microchanneling with ProCell for androgenic alopecia?

Btw doctor whats your thoughts on people consuming drops of minoxidil liquid. Not asking for recommendation cause its clearly wrong but just your thoughts on it.

Can't you just solve this mystery.. it's overwhelming

Do I have to wash my hair with sulfate shampoo anti hair loss forced?

Doctors great video . GFC injection is popular. But what about injecting stem cells derived from Adipose Fat cells from.abdomen area of same person. Can this give better results than Growth factor concentrate( GFC)? Please reply doctors

If we block 5 alfa reductase which lower dht and increases tes. ,,,will that high tes. be converted to estrogen by aromatase inhibitors

Doctor what is your opinion on bicalutamide for hair loss in women. I was on finasteride 5 mg since 5 years but my Dermat just switched me to bicalutamide. Do u think it works well in women?

Please make a video about stem cell therapy for hair growth. Does it work? I have androgenic alopecia and been doing cortisol steroids and mesotherapy treatments but there’s very little to no progress.

Could you please talk about DUPA, retrograde alopecia, and alopecia areata incognito? I'm currently thinning on the sides and on the back and I wonder if you could offer any advice on rarer forms of alopecia? Also, you kind of alluded to this in your video, but could you discuss more about why some medications have no response on the user. Like when you were discussing that minoxidil can only work on certain types of people who have a corresponding enzyme that allows the medication to produce results.

Hey doc, would you recommend a Dr. CYJ hair filler for young male hair thinning in the scalp?

Anything on pep factor for hairloss? Are there any comparative studies to PRP?

Docs. Thanks for videos...i am 67...take daily tadalifil and 2.5 mg oral mioxidil a day ...your opinion...how should i take them...please ..thanks again

What should you do if minoxidil doesn’t work on you? Can you get that sulfate thing elsewhere, or should you forget about minoxidil?

Is it called miso therapy? And is it available in aus?

Please, How about Trioxidil?

Good day dr. Will finasteride affect athletes performance? I see many high level athletes such as rafael nadal, wayne rooney, lebron got multiple hair transplants but continued to thin presumably of not taking finasteride. I play tennis and soccer at an amateur level and don't want finasteride to affect my performance. ( I am 21 years old with diffuse thinning on my crown and mid scalp)

Interesting as always! Are you on medical treatment for hair loss yourself?

Could you do a video on Alopecia Areata incognita?

Does finestride grow body hair also?

Great video! What about Latanoprost and Procapil?

Hi, can Bupropion leads to hear loss?

2:11 I thought 👹🫣

Any benefit to taking both topical and oral minoxidil?

How does oxygen affect the hair

can we get a TLDR?

Hii sir i'm 21 years old suffering from AGA and on finastride 0.5mg daily at night from last 2 months but I'm having erectile dysfunction in night but it's normal in day time can you please help me sir

i lost mine out of shock can i be helped

How long topical finasteride remains in sculp? How many times a week it should be applied??? HELP ❤😢

Tks a lot

I have been taking topical minoxidil daily for around 7 to 8 years but now the greasiness of scalp and on some hair coupled with a few pimples/spots sometimes on scalp is enough. So want to switch to oral minoxidil. I have never suffered any sides on minoxidil regarding fatigue, cardiac or breathing problems. Ive had numerous fbc blood tests over the years always come back in the good to normal ranges as told to me by my gp but my gp refuses to prescribe me oral minoxidil and advises me to keep applying topical minoxidil but the greasiness and a few pimples are irritatting now so I would like to know what amount should i start oral minoxidil on? 1.25mg, 2.5mg or just like the topical minoxidil of 5% once daily? Fearing that if I start too low on 1.25mg I might start losing hairs instead so would it be wiser to start on 2.5mg for say 2 weeks and see if I get any sides and if not then jump onto the same 5mg x once daily tablet? Pls reply and your advice, experience and opinions are most welcome. TIA

I'm 20 years old can i take finasteride??plz answer

Hello ! The first time I used Minoxidil my hair grew and my scalp was not dry. I took a break and returned to Minoxidil 2% for the second time. Please advise me, I have been using Minoxidil 2% for about 10 months, at first the hair loss decreased, scalp became dry, short hair falls out. Now the hair loss has increased. Is there any sense to change to Minoxidil foam 2% or not? Maybe 2 % does not work anymore, that's why hair is falling out and we should switch to 5 % and how to get rid of dry scalp? Thanks !

Minoxidil saw palmetto should be banned it’s such a pain in the rear to use and it’s expensive as hell and it’s all fake or damages ur testosterone

These are old treatments

Doc, is it true that minoxidil causes cardiovascular issues and even ED?

No mention of Prp or lllt?

Good day dr.. I was using minoxidil topical application and finasteride 1 mg for past 2 yrs under the guidance of an dermatologist. Dr told to switch minoxidil topical to oral minoxidil as he didnt find good result. And the oral minoxidil was continued around a year. For the past 4 months i stopped the oral minoxidil and was continuing with only finasteride as i felt palpitation whn i do works. But now my hairs r shedding which worries me a lot. Can my hairs be back to normal since i m still using finasteride?

I have androgenic alopecia all thanks to birth control :(

LONG-WINDED INTRO

Take 0.5 mg finasteride every 2 weeks and thats all you need. Everything else here is over complicated

Another red skull? Curse yo guide you to a thresoure he cannot possess!!!

5 more years… 😂

1st 🙂

The older gent has a good head of hair but I guess he can't do anything for the gray?

Did they say anything?

Uh what’s the new trend?

Their is nothing you can do about going bald

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