Anemia of Chronic Disease - Anemia of Inflammation- All you need to know - Hematology Series 

💉 📜 50 hematology cases are waiting, as well as the answer to today's question...Go to www.patreon.com/medicosis/ 😅 If you like mnemonics, try Picmonic: www.picmonic.com/referrals/JK55NQXQQB9JLC119 👩‍💻Sign up for Dropbox here: db.tt/IIlB8ejxWe 📕📗 Books that I recommend, www.amazon.com/shop/medicosisperfectionalis

كنت حعمل ايه في الكلية من غير شرحك العَظَمة 🥰❤️ شكرآ 💕

Thank you so much from the core of my heart . you made me love Hematology after long years of hating hahaha .im making notes from your video .. youre the best ever

Love your vids. So easy to understand and you make them memorable too. Thank you from a breast cancer patient. Cheers!😎👍

شكرا الله يجزاك خير و يرزقك الفردرس الاعلى أنت و والديك🙏🏻

I am not a medical student but likes to watch your videos....explanation is so simple....I have haemoglobin 9.6 and MCV is 80, MCH is 25.3....I am pure vegetarian ( no egg or meat, only plant based diet and milk). Can you pls suggest something to improve haemoglobin. Thanks and regards

10:05 - my professor says normally TfR increases when the iron is low, such as during IDA. But for ACD, TfR actually would decrease. It is actually a key feature used to distinguish these two diseases.

You have an excellent teaching skill, unique in a very good way. (You have style!)

This channel has helped my cram for so many exams! Thank you! ❤

I think this is the most easy way to learn... thanks a lot for all ur videos and making Pathology easy... Do more...

Acutely I can't say thank you enough.. That's great and very smiple explanation.. Thanks again Keep it up 👌👍👏🥰

Thanks for this video and for providing the concept of the inverse relation between ferritin and transferrin (5:45). Clearly when the liver produces more transferrin the likelyhood for it to grasp more iron is enhanced and moreover, as the transferrin becomes more abundant, the saturation of it would have to go down, which further tends to increase its capacity to take hold of as much iron as possible (and thereby as an important bonus, keep NFBI down). I have become interested - more or les obsessed in fact - with this relation after my last blood work, which I had carried out as a measure to follow up on a 23andMe notification of increased risk for hereditary hemachromatosis. I feared high levels of ferritin of course, but it came to be quit low; 42 mcg/L. This level ought to call for a rather high level of transferrin according to the principle, but it is somewhat below the mid-range level; 2,43 g/L and moreover, my serum iron is 1675 ng/mL which with the given amount of transferrin represents a transferrin saturation of 49%. In short, my numbers does not match with the principle. Apparently I am a carrier (to a moderate degree) of hemachromatosis, but since my ferritin is only 42 mcg/L, I figure that I do not have the disease. On the other hand, my blood work shows that I am slightly anemic, my hematocrit is 39 resp. 38% (measured twice with eight days in between). My hemoglobin is 13,8 resp.13,5 g/dL (measured twice along with the hematocrit). Now, if my transferrin saturation was low (like half of what it is), everything would make sense; I would simply be iron deficient, but since it is 49%, I can only think that something else causes my anemia. I have used long hours in attempts to become familiar with iron metabolism and diverse kinds of anemias, but these topics are complicated and it demand an overall knowledge of medicine to really understand them and secondary to sort out which terms fit certain sets of measures. I tend to think that a hemolytic kind of anemia would reveal itself in elevated reticulocytes, but mine are in the mid-range; 57 resp. 66x10e9/L (also measured twice) and my bilirubin is only 0,59 mg/dL. Besides, the increase of reticulocytes from 57→66x10e9/L in eight days indicates a normal dynamic in regard of erythropoietin resp. erythropoiesis (I presume the first blood draw, which involved some 7-8 EDTAs, left me with 1/4 pint less blood and that the increase over 8 days in reticulocytes - and the decrease in hematocrit in 1% in the same period - was caused by this first blood draw). My Vitamin B12 is 842 pg/mL and my folate is 15,4 ng/mL, both in the higher ranges. The erythrocytevolume is within range; 89fL. My total WBCs are approx. 10x10e9/L. Beside of my RBCs, only my platelet count is critical, it is within range but in the low end; 169 resp. 162 x10e9/L. In short, and to make an understatement, the combination of my ferritin and transferrin saturation levels is a puzzle to me! From the get go, I would expect a relatively high level of transferrin saturation to be linked with a ditto level of ferritin and/or hemoglobin. That is, if the saturation level is high, it ought either to build up a store of iron or provide for a high consumption of it. But none of it seems to be the case. The inverse relation between ferritin and transferrin make sense in relation to iron deficiency, but to a layman, a high transferrin saturation seems counter-indicative to iron deficiency. - Is it possible to be iron deficient with a transferrin saturation rate of 49%? (my laboratory's normal range for this parameter is 20-50%). I am aware that I am in a limbo between two oppositional conceptions 1) my ferritin is relatively low (42 mcg/L) = anemia 2) my transferrin saturation is relatively high (49%) = no anemia. Please, if you, or anybody who might read this, could give me a comment in regard of this paradox, it would be a great help! In regard of my anemia, which primarily is a problem when I exercise (I lose a lot of water for instance when I am running because of heavy breathing), my tentative conclusion is, that I am not necessarily anemic in a formal sense. My 39% measure does not make me anemic according to all definitions at least. An interpretation of my RBC level as low but within normal (non-pathological) range, could for instance be that the level is caused by a low RBC target value in my kidneys. In such a scenario my kidney's potential for producing erythropoietin would be normal and my bone marrow's potential for producing RBCs would also be normal, only a genetical calibration in my kidneys would be what prevents me from having a mid-range level of 45-47% in hematocrit. On the other hand, if I consider my hematocrit as pathological, I cannot find out to what category my condition belongs. In regard of this last consideration, I am aware that both my RBCs and platelets might be caused by a slight dysfunction in my bone marrow. Anyway, both the non-pathological and pathological examples are abstractions and if you, or anybody, can give me a clue in regard of which anemic condition best reflects my blood measures, I would appreciate it very much! Thank you.

Simple excellent unforgettable perfect explanation. Thanks a lot.

I have microcrytic anaemia since I was a child, even before I started my periods. I'm now 38 and still suffer. Been taking B12 and Ferrous Sulfate. I have a bald spot now due to losing so much hair every day. I always feel tired I cannot even walk towards one bus stop, and cannot finish vacuuming a room without panting. It's horrible.

Very helpful video.. Short but detailed.. Thank you so much ❤❤❤❤

So for those with anemia of chronic disease (essential thrombocythemia) that has low iron binding capacity but high ferritin, should they take iron supplements? Thank you. 🙏🏼

Do you think a long bout (12/2 years) of C. difficile could cause anemia? High ferritin, Hb 7.9. Thanks. Superb video.

Autoimmune disorders > chronic inflammation > decreased ferritinemia > impaired RBC production > microcytic anemia (smaller than normal because of less Hgb)

You are life saver ❤️❤️ awesome 😍 my internal medicine exam is tomorrow wish me luck 😭😭

Omg, how good these lectures thaaaanks

thank u so much for making pathology so easy to grasp🙏

My eyes and brain and ears all got blessed 😭😭

Thank you very much. .u are such a saviour. .god bless

Tired and Pale, Pale and Tired 😩 getting some iron TODAY

U sh'd be awarded with Nobel Prize

this channel came to me like a god send, just hope i do well tomorrow lmao

You rock Medicosis!!!

What would be happen to the STfR if there was ACD and IDA? Would it be high or normal?

keep up the good work.

Interesting video. I have Microcytic Anemia, but actually have everything normal and a little "too much" Hb, as in I was suggested to donate except, I have Colitis, still unknown what type I have though, it might even be early Chron's for now.

Hi, my labs are normal and hemoglobin is 14. I have a chronic illness similar To RA. Seems i dont have anemia or am i wrong? What could he causing then if its not anemia? Just trying to understand this information. Thank you!

Really helpful and well done. Thank you!

Great lessons - what are your thoughts if someone has normal iron and very low ferritin?

this was very helpful. thank you very much!

Will you not make clinical chemistry videos ?

I don't understand how IV iron could be a treatment for this condition. Wouldn't it be unable to absorb? When is it better to avoid iron infusions?

Words aren't enough to thank u.. So 👌😍😘

Thank YOU very much 😃😃

god bless this channel

Can be microcytic due to Iron defficiency (7:40)? becasue the number one cause of microcytosis is iron defficiency. Since the body is deceasing the serum iron, maybe that may be a cause as to why this could also be microcytic.

Hello sir,how can WBC's count be normal if there is underlying inflammation going on Kindly explain.And your effort is beyond the words, Stay BLESSED. AMEEN

If body is trying to keep iron away from bacteria then won’t giving parentral iron also worse disease?

Can you do clinical microbiology videos as well?

Why is anemia of chronic disease not microcytic as it behaves like there is iron deficiency?

I again say that! You're the best of the bests'❤️

What if you have high ferritin with high hemoglobulin?

Really awesome 👌👌

thank you my hero

The most common anemia in alcoholics isn’t hemolytic and megalo ?

I love your videos ❤️

Ur voice is unique and so nice 👍🏼

serum iron to TRANSferrin to ferritin. so simple idk why i get so confuse dlol

Can mild anemia be a sign of lymphoma? Hb 12.7, pcv 40, mcv 70 After iron supplementation of 1 month plus Hb 13.1, pcv 40 , mcv 74.5 Please reply😊

I live in Pakistan how do I get acess of your all videos??

What is hepcidin antagonist???

🩸 Hematology Playlist: ru-vid.com/group/PLYcLrRDaR8_eoNz6dxXolh1XMEietcniU&si=tomFsUjAgOKhOJVq

dear i cant see any microbiology videos on site

Great ❤️

Can kindey problem causes anemia?

damn too many ads!! every minute

love u.ur voic I like

Make the video 1.5x faster

Mean good video

I am proud that you are Egyptian

woooowwwww !!!!!!!

2020/9/2

1.25x thanks me later

I have anemia ☹️

I turn pale as heck after gym class

who got nclex ad ?

Murmur*

Who else is on 2x 😂⚡️

Low in iron Just eat a peanut butter and grape jelly sandwich.

Laura

Who is narrating this? Not to be disrespectful, but I can’t listen to it.

Just fix ur sound , u seem speaking in bed