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Anti-Aging w/ Rapamycin Over 50: ApoE4 Carriers Need to Hear This! w/ Alan Green, MD 

High Intensity Health
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Alan Green, MD has been using low-dose rapamycin in his clinical practice for years, we discuss the potential health benefits and ways this can be used as a tool to support healthspan.
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----------------------------------------Show Notes------------------------------------
0:00 Intro
5:05 Rapamycin stops this deterioration and the development of dementia.
9:47 Pharmaceuticals do not treat end-stage disease.
11:15 Rapamycin is anti-mTOR. mTOR is involved in all age-related diseases.
19:35 Evolution’s way to promote new gene variations is to eliminate those with old variations with a short lifespan.
24:40 Ageing is a programed genetic timebomb.
30:50 Slowing mTOR with rapamycin slows ageing.
37:40 Transplant patients do not get the age/health benefits because the dosing of rapamycin is too high.
40:18 Once a week dosing gives a high level at the beginning of the week to knock out mTOR1 and it was low enough at the end of the week to not interfere with mTOR2.
41:15 Reducing mTOR1 reduces the activity of the innate immune system.
42:45 Decreasing the innate immune system is good for stopping chronic inflammation and age-related diseases.
48:30 A typical dose is 6 mg. It is less for a smaller healthy person.
50:17 Rapamycin is good for sports performance because it is good for cardiac performance.
54:10 Rapamycin helps maintain strength and quality of muscles.
55:30 Bodybuilders do not benefit from rapamycin.

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4 авг 2024

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Комментарии : 141   
@Highintensityhealth
@Highintensityhealth Год назад
This one gets really juicy around 37:00! Thanks for having patience, hope you enjoy this conversation.
@drip369
@drip369 Год назад
👍 👍 👍 👍 👍👍 👍 👍 👍
@anonymissed3611
@anonymissed3611 Год назад
Tip: when using a lav mic, put on side of shirt in path of speech. In this scenario, screen left lapel. Have them talk across the mic.
@SMOspider
@SMOspider Год назад
I thought I fell into a time warp ... just then... all the sudden where am I?
@SMOspider
@SMOspider Год назад
and there is a fly on my screen ... I keep wanting to swap it.
@dharma__3
@dharma__3 Год назад
THANK YOU for this! I bet when he was young, he was just like you, Mike ... he just wants to help people.
@loverofthewordofgod4156
@loverofthewordofgod4156 Год назад
Listening to an elderly person is always worthwhile.....
@MichaelMerritt
@MichaelMerritt 10 месяцев назад
Listening to someone running a clinical practice using rapamycin on more humans than anyone else is useful.
@johnb9942
@johnb9942 Год назад
I'm one of Dr Green first 500 patients and stood in that same office and talked to him 3 years ago for over 2 hours on this topic. He's an amazing man. I believe his protocol has made my life better.
@jamesbowen2258
@jamesbowen2258 8 месяцев назад
He seems so incredibly sharp for how old he looks.
@roxanneben1222
@roxanneben1222 Год назад
My parents, 87&84, no meds, 10 pin bowl several times a week, dads in a band, they take care of peoples dogs when they go away, live in their own house, without outside help. My mammy lived to 102.5, and had all her faculties. I want to be like them when I grow up. Presently 61, weight train five days a week, walk my pups two hours everyday, each a meat heavy diet. Think I’m well on my way😊
@jamesbowen2258
@jamesbowen2258 8 месяцев назад
Meat heavy diets are contraindicated for longevity. They improve sports performance in the short run, but high protein diets (especially high methionine diets) cause accelerated aging.
@jax9349
@jax9349 Год назад
My supplement dish is starting to look bigger than my dinner 😕
@orjanbern4766
@orjanbern4766 Год назад
The same applies to me. Having said that, I can't see the BIG benefits of taking supplements, but take them because research/science suggests that it is more or less correct. The only thing I can say with my hand on my heart that has HELPED me is fasting, multi-day fasting.
@epa-c7007
@epa-c7007 Год назад
I can relate. I'm an admitted supplement hoe.
@soyprospera1
@soyprospera1 Год назад
Lol, my husband says our kitchen looks like a pharmacy 😂
@Retrodan680
@Retrodan680 Год назад
Same 😂
@MichaelMerritt
@MichaelMerritt 10 месяцев назад
@@orjanbern4766agree, fasting is incredibly powerful. I need to figure out how it fits into a life on a rapamycin protocol since it hits different pathways (with some overlaps). Fasting is more broadly healing to my understanding. While rapa has more targeted effects.
@IggyDalrymple
@IggyDalrymple Год назад
I will be age 84 in May and yesterday evening I began my monthly 4 to 7 day fast. In about 1 hour I will take 1 mg of rapamycin (I can't afford the full dose). I take the small dose in hope of kick-starting autophagy. I don't really know if all this is helping but as far as I know I'm in pretty good health.
@mnkwazi
@mnkwazi 11 месяцев назад
@IggyDalrymple at what age did you start fasting?
@IggyDalrymple
@IggyDalrymple 11 месяцев назад
Around age 81, but monthly only since the middle of age 83. I'll be 85 in May of 2024. I may have to switch back to fasting once a quarter because it's taking longer for me to regain my strength after each fast.@@mnkwazi
@madison1446
@madison1446 Год назад
Mike, I think this is the best interview I have heard on rapamycin, and maybe one of my favorite of your episodes. Keep up the good work.
@moiragoldsmith7052
@moiragoldsmith7052 Год назад
Thoroughly enjoyed this Mike. That last few minutes especially...research extensively, take back responsibility for our own health... grass roots indeed! 👏💕
@Joy80JJ
@Joy80JJ Год назад
Very interesting info & your a great interviewer as you let your guest speak. Thanks Mike
@chrisarp4111
@chrisarp4111 Год назад
mTor is an interesting subject. mTor is the signaling mechanism for protein synthesis. It’s role in growth of muscle is important. The problem is it’s growth properties for everything, including cancer. I wonder if consistent strength training will channel mTor into muscle growth and away from negative tissue growth. It’s a thought.
@anonymissed3611
@anonymissed3611 Год назад
Conversely, will suppressing motor inhibit muscle mass
@madison1446
@madison1446 Год назад
@@anonymissed3611 Yes, suppressing MTOR will inhibit muscle protein synthesis. I think that is why the rapamycin is not dosed all the time. .... I would like more clarification on: is resistance work still beneficial when approximately alternated with rapamycin?
@MichaelMerritt
@MichaelMerritt 10 месяцев назад
⁠rapa is not dosed all the time because it’ll start surprising mtor2 instead of mtor1. if mtor1 is suppressed long enough. Check out Peter attiya interview with Matt kaberline and David sabatini on it, they go deeep. Building muscle and strength training is complex and it will be impaired to an extent temporarily but the tests done on it are done at peak blood levels 2hrs post ingestion, so worse case scenario. Rapamycin news forums have some good threads on building muscle while on a rapamycin protocol.
@elliottrubenstein1746
@elliottrubenstein1746 Год назад
Just a wonderful interview Mike.
@dharma__3
@dharma__3 Год назад
THANK YOU for this.! I bet when he was young, he was just like you, Mike ... he just wants to help people.
@geotj3044
@geotj3044 Месяц назад
It’s refreshing to hear from someone who has actually experienced aging and who understands these drugs. I’m getting tired of hearing from ripped 30 year old men on the “effects of aging”. Thank you for this insightful interview.
@GrumpyOldGuy777
@GrumpyOldGuy777 Год назад
Great info, ty!
@captainnoyaux
@captainnoyaux Год назад
super interesting thanks !
@flowerpt
@flowerpt Год назад
Excellent - thank you. Maybe take down the electric guitar a few dB on the intro mix on the next one?
@alexandrejuve1305
@alexandrejuve1305 10 месяцев назад
Not easy to find a 79 years old men that seems a centenarian. I feel sorry for him. I would like to take rapamycine (I’m 44), but looking at him many doubts.
@vexator19
@vexator19 8 месяцев назад
I thought he was much older too
@jamesbowen2258
@jamesbowen2258 8 месяцев назад
He was falling apart physically at age 72 due to congenital issues. Most likely still is. He looks bad, but for 79 I think he's very lucid and sharp.
@vexator19
@vexator19 8 месяцев назад
​@@jamesbowen2258Thank you.
@ayliea3974
@ayliea3974 Месяц назад
Consider that he had a serious heart problem that probably would have killed him by now if he hadn't started Rapamyacin.
@2ndstreetmarvel
@2ndstreetmarvel Год назад
🤘🏿Sunday podcast day!🤘🏿
@anonymissed3611
@anonymissed3611 Год назад
If this helps preclinical cardiac issues. recent..err..events..may suggest a deep dive into this....
@anonymissed3611
@anonymissed3611 Год назад
57:11 mtor in young vs old. Building muscle vs maintaining muscle. (Sounds like you better build up before beginning regimen)
@vorsprung2330
@vorsprung2330 Год назад
Hello dear brother I thank you soo much for your efforts Could you please enlighten us in your next videos about resistance training for type two diabetes and overall cure for diabetes please. ?
@Highintensityhealth
@Highintensityhealth Год назад
This is a good start: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-61ognDvXsDU.html
@sek4amk729
@sek4amk729 Год назад
Berberine by Thorne along with daily walks
@harmonizing888
@harmonizing888 Год назад
Good for cancer too.
@stevec3526
@stevec3526 Год назад
Mike, you need to talk with Dr Jerry Mixon in Kirkland.
@hasan6678
@hasan6678 Год назад
Gonna have to play this on 2x 😅
@Highintensityhealth
@Highintensityhealth Год назад
Thankfully no one will complain I'm talking too fast in this one!!
@AncientYouth64
@AncientYouth64 Год назад
😂😂
@randomroses1494
@randomroses1494 Год назад
1.25x
@clint4004
@clint4004 Год назад
Hey HIH have you seen the red light therapy helmets for Parkinson's disease treatment? As well as general brain health...
@rogehnimunoz4327
@rogehnimunoz4327 Месяц назад
He’s still sharp for his age. I think rapamycin does work.
@stefanallard3084
@stefanallard3084 Год назад
Alan, I think you would bennefit greatly from high dose psylocybin, really increase neurogenesis and chock the body with oxygen so it breath more life/energy into you. I think psylocybin is a MUST as we age post 40y
@SMOspider
@SMOspider Год назад
Dinosaurs are like todays AI ... lolz but then Dinosaurs are questionable of their existence. Excellent interview. I learn so much from your channel for so many years!
@aprilek6003
@aprilek6003 Год назад
No offense to Dr. Green in anyway. I know many folks who are in their 80's who look, act, and appear much younger.
@alexandrejuve1305
@alexandrejuve1305 10 месяцев назад
He is in a terrible shape, he seems a centenarian to me.
@jjperry3995
@jjperry3995 5 месяцев назад
He has only been taking rapamycin for around 5 yrs and was already sick when he started.
@rickduker4969
@rickduker4969 27 дней назад
I don't think it slowed his aging but it did relieve his heart myopathy.
@ranghashalatr142
@ranghashalatr142 Год назад
Why It's not avilable all over Nepal
@perryscifi
@perryscifi Год назад
ok, dear guys , i have a little problem, and maybe here someone explain me that, have 30 years old , really fit guy, maybe will take rapamycin but probably around 50 or sth, but i read that probably you can couse some inhibition of mTOR using supplement called caAKG. And i have a problem with that, from one point of view i read about promoting protein synthesis and anticatabolic effect of AKG , from other i read about inhibiting of mTOR, isn't it conflicting, can someone understand this , it is possible that inhibition of mTOR can be in some parts and in other i mean muscles when you practice bodybuilding not? , really try to figure out mechanism of working of caAKG
@thomasd1544
@thomasd1544 Год назад
I kinda, like, may be interested in this, when I, like, get older.
@drip369
@drip369 Год назад
Well think back to one of the women that you interviewed before that talked about not mixing fat with carbs in each meal, but separating them and then another you interviewed that said if you start your day with carbohydrates, you will be craving them all day long so I like to start my day with meat and something fatty and mixing carbs later in the day, if I even need them
@Freyasmom13
@Freyasmom13 Год назад
Same!! Did strict keto for two years and I’ve found now that I’m fat adapted I can cycle my carbs and do my keto coffee in the morning and have carbs later in the day especially when my cycle is coming!! I can actually stop/start my cycle if I don’t have enough carbs or forget to eat (momlife) it’s amazing how powerful the use of fat and carbs can be especially in a Womans body!
@drip369
@drip369 Год назад
@@Freyasmom13 leg days and plyo torso days get carbs. I will lightly sea salt water/Gatorade and have a teaspoon of honey before a run, to keep my throat from drying, otherwise only on Wednesday will I have potatoes with my steaks in the first meal
@drip369
@drip369 Год назад
@@Freyasmom13 sometimes on Fridays to kick-start my longest fast of the week bible have sticky rice with my morning salmon that I have every single Friday all year long but again that's just to help me finish the work day before I start a much more extended fast into Saturday
@Freyasmom13
@Freyasmom13 Год назад
@@drip369 nice! I feel like I felt like carbs were evil for so long but I’m realizing that I don’t have to be so dogmatic in my thinking! I feel like as humans who are tribal we tend to be all out, one team or the other- vegan, keto etc but in reality we can just eat what’s healthy and that’s different for everyone and their needs
@MindDrip
@MindDrip Год назад
Which interview was that? The one with the woman who talked about not mixing fat and carbs in every meal?
@WillowTube
@WillowTube 10 месяцев назад
FYI, San Pelligrino has fluoride in it.
@roustabout4fun
@roustabout4fun Год назад
I seem to have found some interesting info about Rapamycin, both great and not-so-good. V. interesting info here, ideal to build up on many levels and try to maintain as we get past 60 or so. Good practical functionality in out elder years. Pfizer has the patent on Rapamune and it seems to relate both to health and a possible future gold mine. Bottom line~ Enjoyed the talk!
@MusicLovingFool1
@MusicLovingFool1 Год назад
From Britanica: Immune suppression by rapamycin has been associated with potentially serious side effects, including increased risk of infection and lymphoma. Other side effects include fever, diarrhea, joint pain, headache, and vomiting." Um...no thanks!
@M1kl00
@M1kl00 Год назад
@@MusicLovingFool1 that's long term use for lymphoma and serious sides
@Michael-wy7om
@Michael-wy7om Год назад
380$/mo 😂 im going to have to age naturally
@roustabout4fun
@roustabout4fun Год назад
@@Michael-wy7om keep movin and healthy lifestyle in order to doge that grim reaper. lol I agree~
@ramblr5900
@ramblr5900 Год назад
Whats the median age or tipping age when someone is condsider young and old person? 40???
@Highintensityhealth
@Highintensityhealth Год назад
Most people notice significant changes after 50, but it depends on diet and lifestyle.
@GrumpyOldGuy777
@GrumpyOldGuy777 Год назад
Things definitely change after 50 from my experience.
@ramblr5900
@ramblr5900 Год назад
38:35 recommended age around 40 to start thinking about taking it.
@carolinemarie44
@carolinemarie44 Год назад
How do you get rapamycin?
@stevefantastics6595
@stevefantastics6595 10 месяцев назад
Alldaychemist
@atelier27
@atelier27 4 месяца назад
Metformin also slows MTor which is why every podcaster stopped taking it. So Which is it, slow mTor or increase it? And wouldn't metformin that has been more tested and tried and easier and cheaper to get do the same/very similar thing?
@madison1446
@madison1446 Год назад
What is the word that doctor green uses sort of as a adjectives? ... Cirolife?, .... serlion? ...., Maybe before a noun like "HEALTH"? ... Thanks.
@madison1446
@madison1446 Год назад
"sort of like"
@arhu74
@arhu74 Год назад
Perhaps sirolimus? Didn't watch yet though but sirolimus is synonymous with rapamycin
@stevefantastics6595
@stevefantastics6595 10 месяцев назад
I think he's saying "sort of like.". It seems uncharacteristic for someone of his age and education. It drives me insane 😂
@MimiYouyu
@MimiYouyu Год назад
Can u check out how Rapamycin reduces testosterone? Apparrently this is a thing.
@drip369
@drip369 Год назад
*rubs hands together excitedly*
@SeaFlower38
@SeaFlower38 Год назад
😆
@stevefantastics6595
@stevefantastics6595 10 месяцев назад
Something Dr Green says drives me insane... Does he keep saying "sort of like?"
@Freyasmom13
@Freyasmom13 Год назад
Wait is this an antibiotic?? Why is that good? I’m listening but it’s hard to understand
@Highintensityhealth
@Highintensityhealth Год назад
It’s not an antibiotic, it’s an mTOR inhibitor!
@Freyasmom13
@Freyasmom13 Год назад
@@Highintensityhealth ohhh!! Ok interesting!! So as you age you need to trigger mtor bc of muscle loss I’m guessing
@johnandseason5433
@johnandseason5433 Год назад
So, what is the natural version of this drug? Just as Berberine is the ‘natural version’ of metformin.
@arhu74
@arhu74 Год назад
the natural version of rapamycin is rapamycin, a synthetic version would be everolimus
@vegasallen1212
@vegasallen1212 Год назад
berberine and metformin are very different.
@bevillenz
@bevillenz Год назад
@High Intensity Health, do you think Rapamycin is being used by cyclists at the World Tour level? It doesn't seem to be on the banned list. Also I'm interested as a 45 yr old competitive masters road cyclist. Cheers.
@tomwoodall1463
@tomwoodall1463 Год назад
Im a couple years older than you, honestly, I’m not ready to buy that we don’t need mTOR at our age. I think until we are 50, 55 or so, taking it less frequently than once per week is a better idea. But hey, I have no f’ing idea in reality lol
@arhu74
@arhu74 Год назад
I don't think any do but from experience I can say it won't hurt. I increased my FTP by 24W this winter whilst taking rapamycin (doses varuimg from 2mg to 16mg with grapefruit juice but on average 6mg with grapefruit juice fortnightly) but my FTP isn't that high (254->278 @75kg 48y/o) but still 24W is 24W
@Viertelfranzose
@Viertelfranzose Год назад
As a Cylinggeek with 53 years I would interested where to buy the RapaStuff😄 which should be a trusted Source and Shipping to France...(or to my MyUS Postbox).. Thank, you very much and greetings from Andreas in Alsace /France
@arhu74
@arhu74 Год назад
@@Viertelfranzose I self-prescribe but I heard there are online european MDs that write prescriptions that are valid in the entire EU
@Viertelfranzose
@Viertelfranzose Год назад
@@arhu74 Thank you... I thought I could buy it like Bromantane or other Nootropic Stuff...without a MD
@drip369
@drip369 Год назад
20:11 which proves that everything had to be designed to work the correct way, instantly, because if things didn't work, everything would have died and no code could be passed on. If something isn't designed to survive, it will die and you will never see it again. This is insane to think that one person didn't have everything it needed with its brain gut and organs but it was able to passcode all by itself to become something that could reproduce. Miss me with this nonsense. Google tells me to imagine the shoulder evolved from the oblique muscle but how in the world would humans have fed themselves without the shoulder muscles so that they had the energy to reproduce and then feed themselves again without shoulder muscles to go out and provide so that child has a chance to grow up and reproduce. It's impossible for something to not work and reproduce if it wasn't designed to work and reproduce at the start
@drip369
@drip369 Год назад
Explain to me sir how the Lord says he pulled man out of the soil and all of the minerals found in soil are found in each of my cells in my body, but evolution says I came from a fish that somehow developed the ability to breathe on land before it died so that it could pass on code. Honestly if that fish came on land and died, it's dead, and it can't reproduce something that can breathe on land. It died! You people have been sold a lie and everyone is still trying their hardest to validate something that requires blind imagination. I'm sorry, Mike, you got to 👍, I will fast forward so you get a complete view, and you got multiple comments, but I can't listen to this mumbo-jumbo no more
@rhydyard
@rhydyard Год назад
How old is Alan Green MD?
@Highintensityhealth
@Highintensityhealth Год назад
81 I believe
@laraross2701
@laraross2701 Год назад
@@Highintensityhealth Only? Wow, he is doing something wrong! Sorry!
@madison1446
@madison1446 Год назад
Remember, Dr. Green had a heart problem! Before starting wrap a micin rapamycin.
@anthonyeves2005
@anthonyeves2005 Год назад
@@laraross2701 i agree, I honestly, wholeheartedly thought he was going to say something like 95 years old, when asked how old he is... but guess it depends what medical condition(s) he's had to contend with.
@travisedmundson8687
@travisedmundson8687 Год назад
@@anthonyeves2005 You have to take account he had health issues before he started , they resolved with rapamycin. Plus he doesnt lift weights. Muscle loss is real if you dont lift weights no matter what you take
@atelier27
@atelier27 4 месяца назад
In cell studies, treatment with rapamycin reduced follistatin levels and follistatin is touted as an anti aging, muscle anti muscle wasting protein and is contraindicated with rapamycin. Again, too much contradictory advice for how expensive and potential side effects at the moment.
@loverofthewordofgod4156
@loverofthewordofgod4156 Год назад
What is Emptur?
@Sherukka
@Sherukka Год назад
Search for mTOR
@MindDrip
@MindDrip Год назад
mTOR
@VoltEquity
@VoltEquity 6 месяцев назад
he means MTOR, the target of rapamycin
@roxanneben1222
@roxanneben1222 Год назад
A time bomb in genetic makeup 🤔. MNRA, that’s all.
@WeBeGood06
@WeBeGood06 Год назад
I would have guessed 90 to 95, not 80.
@lkpnda287
@lkpnda287 Год назад
Wow I don’t know if it’s certain ethnicity, but my pops os 80 and he literally looks and is like a healthy 40 yr old and agile. And my grandmothers are both almost 100 and bouncing around. This guy look Older and sound’s older than them. Proofs in pudding so I think I’ma gonna stick to what my parents and grandparents are doing. Some is due to our DNA, but the most part is lifestyle and our culture eating style. 🤷🏻‍♀️
@vegasallen1212
@vegasallen1212 Год назад
80 and looks like healthy 40??
@alexandrejuve1305
@alexandrejuve1305 10 месяцев назад
@@vegasallen1212We need more info about this miracle. We need every thing that they do. 😊
@tomwoodall1463
@tomwoodall1463 Год назад
When Dr. Green says taking rapamycin once weekly makes you burn “cleaner fuel”. What the heck is he talking about? Personally i dose rapamycin much less frequently than once per week, so i can keep some mTOR going for my muscles. But do I need to take it weekly to tap into this “cleaner fuel” he speaks of? Either he was speaking way down to the layman, or he doesn’t know what he’s talking about? I honestly can’t tell.. no disrespect intended here!
@TheBroSplit
@TheBroSplit 5 месяцев назад
How do you dose it, how old are you and where do you get it lol, any benefits?
@anonymissed3611
@anonymissed3611 Год назад
Umm...innate immune system is involved in managing cancer cells, no?
@TheCynthiaguy
@TheCynthiaguy Год назад
Background music is distracting.
@KennethLeeAtLGA
@KennethLeeAtLGA Год назад
This guy is 122 years old
@hoffmancapote
@hoffmancapote 2 месяца назад
Well being he is the world's oldest man he is looking good
@renatodoe6661
@renatodoe6661 Год назад
Just don't eat ice cream. You'll never be able to compensate for the damage you'd be doing to your body.
@mats8038
@mats8038 Год назад
why because it is cold,, hehe
@ramblr5900
@ramblr5900 Год назад
First to say first!
@Annetvanb
@Annetvanb Год назад
Why this horrible music?? I want to hear what this man is telling us…😢 This music is way too loud and makes it impossible for me to hear him 😟 Could you please remove the music? 🙏🏻
@Highintensityhealth
@Highintensityhealth Год назад
Fast forward through the intro :)
@waynerichardson1051
@waynerichardson1051 Год назад
Stop winging before you've heard past the intro bro! Too quick to complain!! You know the type!! You!
@XinLi
@XinLi Год назад
Obama must have taken speaking lessons from this guy.
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