Antiplatelet, Anticoagulant, Thrombolytic Agents

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Official Ninja Nerd Website: ninjanerd.org
You can find the NOTES and ILLUSTRATIONS for this lecture on our website at:
www.ninjanerd.org/lecture/ant...
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on Anticoagulants, Thrombolytics, and Antiplatelet Agents. Please be sure to use the table of contents to visit all of the chapters we have available in this detailed lecture. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:07 Anticoagulants, Thrombolytics, Antiplatelets Introduction
1:03 Platelet Plug Formation
26:53 Coagulation Cascade
50:29 Fibrinolysis
1:00:45 Test Your Knowledge - Anticoagulants, Thrombolytics, Antiplatelets MOA
1:04:07 Neurological Events
1:10:41 Cardiac Events
1:27:34 Pulmonary Events
1:32:03 Peripheral & Central Vascular Events
1:44:29 Venous Thromboembolism Prophylaxis
1:48:59 Prevention of Circuitry/Catheter Clotting
1:53:32 Acetylsalicylic Acid (Aspirin) Adverse Effects
2:00:05 Aspirin Toxicity
2:02:57 P2Y12 Receptor Blockers Adverse Effects
2:13:15 PDE-3 Inhibitors Adverse Effects
2:15:07 Heparin (UFH + LMWH) Adverse Effects
2:26:50 Direct-Acting Oral Anticoagulants (DOACs) Adverse Effects
2:30:36 Warfarin Adverse Effects
2:39:21 Bleeding! Most Feared Adverse Effect
2:45:50 Drug Level Monitoring
2:55:10 Drug Reversal
3:02:30 Anticoagulants, Thrombolytics, Antiplatelets Practice Problems
3:10:18 Comment, Like, SUBSCRIBE!
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Опубликовано:

31 май 2024

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Комментарии : 306

@collinstage97 Год назад

This man and his team should get a Nobel Peace prize for the amount of medical education they put out for free

@DanielM-il4rz Год назад

@Collin Stage , with over 2million subscribers, all the ad links and just the vast amount of videos uploaded to RU-vid, don’t worry, “Ninja Nerd” is getting paid!! I do agree, they do a great job with the wealth of knowledge that is provided by this channel. 👍❤️

@AlexanderHardy-hj5dy Год назад

"accurate medical education"

@emmanuelmukuka5049 Год назад

@@DanielM-il4rzhh hyhhhhhhhhhghhh

@Smtout1 Год назад

Agreed

@jenavdg Год назад

Bro, unbelievable how you keep two hours of material in your head without notes or power point. Absolutely gifted

@markmurto Год назад

He took breaks. Had to. But you're right!

@jundelira7119 2 месяца назад

I think , he is an A.I.

@Medical_life_with_John Год назад

Ninja is Albert Einstein of the 21st century.

@wanahmadamsyarzafrie8080 Год назад

Nah not even Einstein has his own website to help people all over the world

@druutlectures Год назад

Indeed

@enzamamahmed277 Год назад

Indeed

@user-do5fn4ou3x Год назад

😂 😂 😂 😂 😂 😂

@Iceblack002 Год назад

True

@lyricsmusic4569 19 дней назад

I swear we have a lot of professors and professors and many who hold high academic degrees, but not everyone who holds a degree becomes a teacher in my opinion. Those who are able to simplify and communicate information are the ones who deserve to be appreciated and called professors, not those who hold a degree without being able to communicate ideas as well. Do, may God bless you, and we are always waiting for everything new from you. All the love from Syria❤

@user-nr8xi4we2h Год назад

Protect this man at all cost! Cant thank you enough for simplifing such a complex topic, once again! Long live Professor Zach Murphy!

@RambabuLakavath Год назад

We admire you from india. Iam a resident in internal medicine . To know any concept i will watch ninja nerd channel then i go to text books. Really we are very much in debt to you for this wonderful teaching. You have world wide fans sir

@mferso Год назад

I Apreciate your tremendous effort to do these classes. I can say your class is much better than many professors!

@LilFella67 Год назад

Great content. One thing to remember, inpatient treatment of a confirmed clot (DVT/PE) requires heparin (or LMWH) combined with warfarin for a minimum of 5 days and INR >2 for 24 hours to prevent rebound clotting. Warfarin’s half life requires a much longer time combined with LMWH/Heparin to provide full anticoagulation. For DVT/PE prophylaxis, the overlap can be less.

@qman1131 Год назад

Would you ever use tPA for a DVT/PE? I only hear about tPA for ischemic stroke events, but couldn't it help with DVT/PE as well?

@LilFella67 Год назад

@@qman1131 Zach talked about using tPA infused directly onto the clot. We employ this option at work. Typically, it’s a low dose infusion directly onto the clot as the location is identified with radiology. That’s for DVT. We don’t use it with PE. Obviously, it’s a lot harder to feed the catheter to the clot location in the lung.

@nkemezekwe1382 Год назад

I don’t think I’ll ever come across anyone that can teach like you, U take a person from stupid to genius. Thank you.

@pheonixigniteakafaizan7545 9 дней назад

Honestly U are the best Your lectures are what makes MBBS interesting

@CaseyRoff Год назад

Zac and the team... what the heck did I just watch? This was EXACTLY the lecture on antiplatelets, anticoags and thrombolytics I needed. I was always confused on why we give P2Y12 and ASA for MI and not Heparin, ASA and P2Y12 for stroke ect ect but this just made it so clear. Then you give reversal agents, drug monitoring and case examples just to remind us that you're not just a channel for pre-med but for clinical med students too. Love it so much and so happy with how far you guys have come.

@ginaramnath1268 7 месяцев назад

This man (and the entire team) is a GOD-sent.

@garlicbread301 Год назад

Someone give this man a crown. He's a king!

@sivajinidarmendra2250 Год назад

Dear Professor, you're AMAZING....We all love you man.

@lucaspreafico7298 6 месяцев назад

You are literally the substitute of my real pharmacology teacher

@muqtadaqutaiba2882 Год назад

Thank you so much!! This pharmacology series is the greatest of all time no doubt

@dsch522 Год назад

Zach your videos have been so incredibly helpful. My 62 Y/O wife has had Lupus since 1985. In 2015 her mitral valve was replaced due to Lippmann Sacks, in 2020 she had a massive DVT, and in October a subdural hematoma followed by bilateral PE’s, followed by an even bigger subdural. Your videos really made a difference. Whether Hematology (Platelets) or Brain anatomy. I seem to always find one of your videos that make it more understandable.

@MrMiningsolutions 7 дней назад

"Live Long and Prosper', and above all, have kids as brilliant as you. Thank you for the knowledge and for your enthusiastic demeanor sharing it :)

@PravinChandran1983 Год назад

this huge, beautiful video about the anti-coagulants is beyond comprehension, how you get the patience and persistence to make these marvelous medical science videos that benefits folks all over the world in medicine and paramedical /nursing etc. ? , thumbs up to all involved and take care and thanks again,

@ayshadalieva9929 Год назад

Huge gratitude from AZerbaijan. I don't know how I would be able to study medicine without your help.

@imanmeer7041 8 месяцев назад

Best lectures i have ever come across, bless you Zach🥰

@99Valem Год назад

i have a pharmacology test on monday about this, i cannot thank u enough, i feel like u read my mind haha

@qman1131 Год назад

This video came out in just the right time for me thank god.

@BilalAhmed-if8rv Год назад

**hello zach in this lecture at 36:37 you have mentioned that gamma glutamyl transferase make proteins functional that are factor 2, 7, 9, 10, protein c and s but in another video of you on warfarin you have mentioned that it is gamma glutamyl carboxylase that make these proteins functional, the book I am studying for pharmacology is katzung and in that the enzyme mentioned for making the proteins functional is gamma glutamyl carboxylase not the transferase. So, I think it is a mistake.

@aurelienguitton4097 Год назад

You king, thank you for all you've done for me chief !

@Lungmanvictor Год назад

I have watched this video now 3 times in my ECMO training. You have the ability to make it all very simple for me to understand. Oh, I wish the Ninja Nerd: Doctpr Classic came in a white. Bought my brother one already.

@Jetjetson Год назад

Wonderful to see u Zack. Your ability to impart knowledge is Magic. Your art is your beauty and your beauty is your art 😊 Master Diagramming

@Drjpharmacy Год назад

Pharmacist Intern here 🤘🏽 and I approve of this video 😎 especially all of the drugs listed and the MOA. Drugs is our specialty

@janetombe6027 Год назад

I'm lucky to have you. I love your teaching. God bless you

@ninodiogenes949 9 месяцев назад

Awesome, always the best! tks a lot from Brasil.

@cca8244 Год назад

Thank you for your hard work! I am definitely a visual learner so really appreciate this form of education which is even for free. You're doing a great job with each video. Greetings from Germany

@NaveedAhmad-xb2io Год назад

Great Work Professor Zach. You have made Pharmacology so easy.......Please make a video on CNS Pharmacology and Anti-psychotic Drugs & Epileptic drugs.......Love from Pakistan

@druutlectures Год назад

Zalim apnay Pakistanio k lectures Nahi milay Kia ? ☺️

@selenaserane2623 Год назад

Wow i finally finished the vedio! Its not about marks anymore, its about learning new stuff everytime,huge thx to zach and the crew

@eudorinaulva8123 Год назад

You and dr najeeb are my saviors in med school.....thank you so much for doing this ❤❤

@yhkuo870 9 месяцев назад

thank you so much for connecting all the knowledge........ from physiology to clinical importance! Much appreciated!

@sukh6566 Год назад

Went straight to this video, came out at the perfect time for me !

@DanielM-il4rz Год назад

Great job! Hospital Pharmacist here!! Job well done. 👍😊

@kxcreative6064 Год назад

how many of those drugs you know

@DanielM-il4rz Год назад

@@kxcreative6064 I have heard of and understand all of them…although, our hospital (like most Healthcare Facilities) only keeps a selected number/type in stock. Most hospitals have a formulary of medications that are stocked and used on a regular basis.

@MsEducatedScholar Год назад

I love this channel. I found it this semester, my last semester of nursing school, and it’s so hopefully! I took anatomy several years ago & these videos are great at helping me remember things I thought I forgot. Zach, is an excellent teacher and it’s great to learn from someone who is excited about teaching, as it shows in his lectures. Please consider a way that students, grads, etc. can contribute to your channel to help it and your website grow. I refer classmates to your channel weekly and it’s so appreciated! ❤️

@sureshkumar.t1300 Год назад

Sir we are from India no one give good content in general pathology neoplasia and all pls take general pathology also sir in your style ☺️

@waleedhussain9311 3 месяца назад

This guy must be from another planet .Hats off. Salute 🫡 .no words can define your efforts 👌.

@AAUN Год назад

Among the antoplatelet drugs the commonly used drugs are Aspirin , Clopidogrel etc. Anticoagulants include rivaroxaban , abigatran and edoxaban . While prescibing these drugs proper education of patient is extremeny important.

@kelvinchan3069 5 месяцев назад

Thank you for all your hard work. Much appreciated.

@16parag 11 месяцев назад

Thanks Prof Zach for the beautiful and simplified lecture as always !! I would like to add 1. platelet transfusion is inefficient to reverse the effect of Ticagrelor, because circulating ticagrelor and its metabolite are likely to inhibit the fresh platelets. 2. Bentracimab is an antidote to Ticagrelor, it is still under trials though. It binds ticagrelor and its active metabolite with high affinity and specificity. 3. Apixaban clearance is less dependent on renal function(only 25%) compared to other DOACs and it is approved even in ESRD with reduced doses.

@sajiruddinsk8129 Год назад

Don't compare with another, Ninja nerd is the best lec

@wwdpm 8 месяцев назад

Long live zach.. You help me a lot. Cant say anything more than thankyou. God bless you.

@mustafaahmed4091 9 месяцев назад

Thank you, Amazing work!!

@markmurto Год назад

You were such a good teacher that I got all but one of the questions right at the end, [and that was the one where you said two choices, one was better in that case]. So I did pretty good and I'm not a medical student. I'm just a mechanical engineer type who loves this stuff.

@sawantiparang6660 Год назад

Sir,,please keep all pharma lecture in one playlist,,it ll be easy to search

@user-nf1to7bp2d 11 месяцев назад

Absolutely fabulous content and gripping presentation! If only every teacher could grab people's attention this well! Oh, but the ads! I was getting bombarded by 2 long ads every 5 minutes. There are also 1-2 ads to watch every time you jump back or forth to watch a particular section again. The excessive ads really destroy concentration, which is the opposite of what you want to (and do) achieve. They made me so mad, I just wanted to swat them out of the way like flies. After this, l will never, ever, ever order Lieferando! Your videos are great! Surely, there must be a less intrusive way to monetize?

@abdirahmanmubarak4131 3 часа назад

Wonderful

@serahmed5346 4 месяца назад

The effort you are providing to teach us is incredible. Thank you so much sir Zach Murphy

@TOMMY-xo1rq Год назад

A walking work of art 🎨. Thank you sir ❤ .

@zackbullock8198 Год назад

Thank you for what you do! You have given answers to many questions I have about my condition. I have watched many of your videos.

@achalakp705 4 месяца назад

The coolest explanation ever thanks for making me pro...and and wait...I'm not gonna get screwed up from my teacher. ❤

@troykarlwena9115 Год назад

Thank you Prof. Zack Murphy, your video does help me alot. Not, only this one but all of your videos. I'm with you all the way from Papua New Guinea 🇵🇬. Please, do more videos to help us understand more. Your biggest fan.

@atsbhah1971 2 месяца назад

I wish you released these videos when I was in med school, but I am making the best of them even now.

@harshitagautam9414 Год назад

Thanks a lot for your hard work Your explanations are awesome Can you please cover Tuberculosis next week.

@lananhtran9345 10 месяцев назад

Awesome. I've learnt deeply all of knowdledge in this video. It make me clearly understand about antiplete, anticoagulation and thrombolytic mechanism. Thanks for a lot!

@moa4950 Год назад

Hi! Could you do a vid on lower limb amputation, or just amputation at some point? Maybe some possible causes, different types, functionalities of each, and recovery or something? Please and thank you :)

@gib3666 2 месяца назад

I agree with you 100%! Thank you very much for posting this video. I hope this topic will touch many hearts and help all to practice your suggestions and lessen their hardships and sufferings. Thank you again. ❤

@johntom2362 6 месяцев назад

Thank you very much Prof.

@arbazahmed14000 4 месяца назад

If I gonna watch movie’s or drama’s After 20-30 minutes I will shut down But whenever I’m watching yours lectures even if it is more than 3 hours i want to continue like a marathon !!! Love you 😘

@Medical_life_with_John Год назад

Ninja is Don of medicine.

@SnowInHere Год назад

Keep up bro, your lectures are the BEST out there!

@salvadorhirth2919 Год назад

You're the best!

@dr.ss-4077 Год назад

Please cover whole pharmacology playlist my exams are near you r my hope ❤❤

@abrahamendale2729 Год назад

I appreciate you my bro from Ethiopia

@getxited 6 месяцев назад

Wow listen you are one of a kind !!!! Infinite and accurate knowledge love it. Thank you sssooooooooooooooo much

@mohammadnawaz4450 Год назад

Love you Zack and team oh my god! You guys are doing great great job new pharmacology series love it from my heart

@DanGuz-wn9fq Год назад

THANKS Dr. Finally getting the real eXplanation Of my PE I LOVE UOU NOW BY ADMINISTRATION

@madieingman1450 8 месяцев назад

These videos have been saving my life while in school! I absolutely love the content and find it easy to follow and so helpful in understanding difficult topics!

@solsanchez5228 Год назад

Wheew!!! You're the goat Prof. Much awe and respect🥰

@woderyeleshkefale9791 7 месяцев назад

Thanks a lot for your effort to share your knowledge with us

@Usanov19 Год назад

oh. ninja nerd best of the best in the world. thank you very much for tish best lecture👍👍👍😁

@ankitkumarsingh1998 Год назад

learning just got so much easy!

@meerwasil842 Год назад

Thanku so much my beloved teacher you have helped me a lot....

@segunpeters6201 Год назад

Another excellent lecture. Thank you For the activation of vitamin k dependent enzymes, I suppose you wanted to say gamma glutamyl carboxylate rather than gamma glutamyl transferase

@indianasb59 7 месяцев назад

You are such an amazing teacher!!!

@queteimporta7049 3 месяца назад

You deserve the best

@angela2366 Год назад

Fantastic information and so easy to understand! Thank you for taking the time to teach us!

@gabriellukwesa7174 11 месяцев назад

i will always remain a ninja nerd supporter. my number one tutor🤩😇

@Heavyset_ Месяц назад

i fell asleep and woke up to this

@hammbaby 2 месяца назад

god the platelet plug formation and anticoagulation was a beast just like you said, but you taught it so well, thank you ninja nerd team and once I get paid I'm going to sign up im looking forward to the notes yall have!

@fas451 Год назад

He is the best 💯💯💯

@gwynettsiriban3470 9 месяцев назад

I've been here since high school and you've helped me alot

@sayanpan6923 Год назад

Can u pls plss pls pls do a video on antipsychotic pls within 2.. Days i know I'm asking a lot but it's for my exam.. And you are the best i have ever seen in my life so pls.. Thank you for everything you are doing for us but can u pls do a video on antipsychotic.. It'll mean a lot a lot to me

@vinceh1306 Год назад

Amazing work, job well done!

@camilojoseacevedo8525 Год назад

The only Word that discribe this and all videos is ..EXCELLENT..!

@gareebameer 3 месяца назад

Finally completed the video and made notes 😎

@tonylee1835 4 месяца назад

Incredible teacher

@OmarFarouq-wz8hf День назад

Amazing

@user-ly1jx4mj8r Год назад

Than you so much for extensive explaination

@zaidkhan-yc3fd Год назад

Thank you sir. I become sedative to watch your lectures . I always search ninja nerd for new topic

@tigerhillsupa Год назад

It took so much time to digest! however it is the best lecture for anticoagulation

@jerrycarson5085 Год назад

Unrelated question, I had a fusion on L5-S1 14 years ago. It seems scar tissue grew into S1, S2, and been on Pain Mge for the past 12 years. Now, over the past 6 months, I've been having pain around my right side, just above the right hip. My GP sent me for scans and all came back good, (no problems anywhere). Last Monday I was having coffee at a local shop and talking about the pain in my side, in the next booth a person said it sounds like a nerve in your lower back, WOW, can this be?