I am a cardiologist and eventhough I know all these stuffs in my head I watched your videos to learn how to explain it so clearly to my students. However at this point I would just give them the link to your videos because I doubt I can explain it better than you with all these graphics😂 really well done!
Your lectures help to clear the concepts about the particular subject.... our vision becomes crystal clear. No matter how many times I read antiarrhythmics, I used to get confused and frustrated. But hey, after watching this full video, I feel a lot confident about the topic now!! I really admire the efforts you guys put in to teach the subject. And I adore your capability to learn, understand and then teach any topic that you present. I am following you since a year now, and not a single lecture was there where I got bored or neglected the teacher 😉. You have the mesmerizing capacity to keep your audience glued to your lecture till the very end, and very few people in the world harbor this captivating ability... you stimulate me to study hard and harder. I can't thank you enough. Love you guys! Be blessed always. And keep teaching!!!
I appreciate your videos. I'm a firefighter/Medic and I watch your videos periodically as a refresher. Your take on physiology and the way you teach fits my learning style perfectly.
Quick tip to help you understand better: Inside of cell is more negative than outside of cell AT REST. This means they are polar. Opposite charges (the old saying polar opposites). When a cell depolarizes (de=not) the inside of the cell is becoming more positive meaning they are becoming less polar. When the cell depolarizes (re= again), it is becoming negative again back to the resting state of the cell.
Besttttt lecture on RU-vid i have watched alott of lectures but i didn't understand....it was sooo confusing topic but you made it look sooo simplee..... thank u zack❤
I came here because I'm talking carvedilol and somehow it changed my heart rhythm even though the cardiologist says it didn't Now he sent me to the rhythm specialist to get an ablation... Anyway I came to educate myself... You're the best Ninja nerd 🤓
In your video particularly at 8.27 you mention that voltage gayed na+ channel open and it open ca2+ but in diagram you not mentioned any na+ voltage channel that open at threshold
1:47:45 The " proarrhythmic effect " of class 1C antiarrhythmic drugs is likely related to their effect of decreasing myocardial conduction velocity , which predisposes to myocardial reentry around and through regions of infarcted myocardium .
DANGGGGGG!!!!! That was a beast! I do have a question about amiodarone... Because of the SUPER long half life, is it even worth holding a single dose of PO amiodarone in a patient who is slightly hypotensive (90's systolic)?
Wow I was thought this topic today in the afternoon in med school, I'm preparing to write pharmacology test by end of this month. I pray I pass coz there are lots of things to know like drugs and mechanism
Hello- beautiful video! Quick question - at around the 1 hour and 13 minute mark, you said "these can, to a very mild degree, block voltage-gated potassium channels". Should this have been voltage gated calcium channels (in reference to adenosine and digoxin)?
excellent video. A in-depth explanation of all type of antiarrhythmic drugs. One thing I want to clarify, about the betablocker. In view you mention it will block the L-type Ca channel of the cell at the end, does it slow down / lengthen zone 0 longer instead of zone 4?
Thank you Zach for your dedication and passion. I love details and you are a master in that! I always tell my class that if you want to get by learn the concepts, but if you want to make a difference or discover something learn the details. Hey I just discovered something - Double Quarter Pounder with Lecture and Fries Please. Mnemonic to remember the class I antiarrhythmic drugs. I love it!
First of all: Thank you for the amazing lecture! But, let me please ask you>>>>>> Guys, I still don't get that flecainide cautions. Why is it PRO-arrhytmic? Why is it contraindicated in MI, LVH, HF, CAD ? I'm just confused. If it is that risky to administrate that drug, is it still relevant for clinical use? what if the patient misses crucial things about his past medical story? Please help xD Thanks
I am losing my mind over Class Ib antiarrhythmics. They just don't make any sense. How would a modulation of sodium channels shorten an action potential, when the duration of an action potential is dictated by a calcium influx and potassium efflux???
57:10 a little clarification needed here. It’s here that B1 blockage reduces phosphorylation of L-Type calcium channels I’m a bit confused as to how that affects phase 4 in AV and SA nodes what in there normal physiology it’s the T-type calcium channels that’s bring the MP to threshold. Can you clarify this for me 🙏🏾?
Im asking the same question! haha i cant figure it out. I have read in a few textbooks and journal articles that B1-receptor agonism leads to increase Na influx throught the funny current (HCN channel), so i suppose if you block this effect this would lead to a prolongation of phase 4. But i am similarly confused as to why blocking L type Ca channels would lead to a prolongation of phase 4, more so then phase 0
I know you would think right! But the most explained MOA is that it affects the L-Type Ca channel, but primarily doesn’t open that channel in the late phase of phase 4. This leads to a delayed opening of the L-type calcium channel and prolongs phase 4. Hope that helps
@@NinjaNerdOfficial thanks you are absolutely fantastic🤓, omg I thought that I will never get a reply back,(literally immediate response) have a great time in Hawaii
thank you perfect video ! can someone answer this : slowing down the influx of sodium ions into cardiac muscle cells causing a decrease in the excitability of the cells it has a beta adrenergic blocker which can cause bradycardia and bronchospasm : sotalol propafenone verapamil mexitilene
For class I here's a better mnemonic :) We have a few more drugs in my school. Double Quarter Pounder with Lettuce, Mayo, Tomato, also Fries, Pickles and a Milkshake IA: Disopyramide, Quinidine, Procainamide IB: Lidocaine, Mexiletine, Tocainide IC: Flecainide, Propafenone, Moricizine
