Biologist Explains One Concept in 5 Levels of Difficulty - CRISPR | WIRED 

Level 1 : what you learn Level 5 : what you get on a test

Level 1: Explaining Level 2: Deeper Explaining Level 3: Conversation Level 4: Discussion Level 5: *Interview*

"i'm allergic to penicillin and azithromycin" - round of applause for the parents

Level 2: my knowledge before a test Level 5: what my classmates are discussing before a test

Level 1: who Level 2: whom Level 3: whomst Level 4: whomst'd Level 5: whomst'd've

Notice how the video shifts from explaining crispr to debating crispr.

7:17 *Level 5* Me: _hol up....... theres a little under 10 mins left there_

2:44 I love how she just drops the P53 protein knowledge out there all the sudden. Definitely subverted the expectations of a lot of viewers there I bet.

Poor dude, as soon as he gets to lvl 4 and 5, he doesn't even get to talk anymore.

kid: “I’m allergic to penicillin and azithromycin” me: *is wondering how i skipped all the way to the grad student*

Exactly how my biology degree is going, the more you learn the more it goes into ethics

Child: im allergic to penicillin Expert: i love jurassic park oH mY-

I'm in the level between child and the exact moment before the teen mentioned P53

Level 1: Explaining basics Level 2: Asking questions Level 3: Explaining technical level Level 4: Agreeing about everything Expert Level: CRISPR's actually kinda shitty tbh let's talk about Jurassic Park instead homie

Level 1: he teaches Level 2: he teaches a little bit deeper Level 3: he has a basic conversation, but he knows a little more Level 4: they both know about the same and have a back and forth discussion Level 5: *he gets taught by the interviewee*

"If you can't explain it simply, you don't understand it well enough" -Albert Einstein

Do you know what CRISPR is? Me: Yes I believe every potato chip could be CRISPR.

"If you can't explain a subject simply, then you don't know it well enough" - Einstein

How an oversea student feels about this video clip: Level 1: English Beginners Level 2: English course textbooks Level 3: What IELTS/TOEFL will test on Level 4: Daily conversation Level 5: University Lectures

The teen is definitely in ap bio, sis knew what the p53 gene was lmao

Level 1: Kid Level 2: Teen Level 3: College Level 4: Grad student Level 5: Expert Level 6: Random Chinese kid

People: i just don’t think people should be able to use it for cosmetic purposes Scientists: bold of you to assume we know how to do that.

I love how at first he’s teaching them, by end he’s getting taught like literally just listening.

Lvl 1: I understood Lvl 2: hmm interesting Lvl 3: I am lost Lvl 4: still lost wait what Lvl 5: I am in space

To kid: have you heard of CRISPR? Do you know what the genome is? To expert: can we have Jurassic Park?

Level 1: What is CRISPR Level 2: What is CRISPR Level 3: ETHICS Level 4: ETHICS Level 5: Dino's!

I’m doing a Master’s Degree in Genetics and CRISPR-Cas9 is my favorite subject. The level 5 conversation is music to my ears ❤️

Job interviewer: so what made you want to be a bio engineer? Neville: Um I watched some movies on dinosaurs and stuff Interviewer: O.O you’re hired

Child: Genomes Expert: Jurassic Park

lv 1: teaches CRISPR lv 2: quizzes CRISPR lv 3: surveys CRISPR lv 4: reviews CRISPR lv 5: advertises CRISPR

I like how in most of these type of videos, when they get to a professional, it's someone they've met before and it's as if they're just catching up.

I’m a biochem major, the level 5 was really interesting. CRISPR has huge possibilities, but it going wrong in a patient could have huge repercussions. Tread lightly scientists

Mitochondria are the powerhouses of the cell.

Low key I'm pretty impressed this teenager knew about p53 hahaha

This is why peer review is SO IMPORTANT. It’s a checks and balances system for both the primary scientist and the society as a whole.

I attended high school in Italy and i learned about Crisper during biology class like it was at the same level of knowing the mitochondria is the power house of the cell. I think its really nice how they teach biotechnology in high school here!

can you explain memes in 5 levels of difficulty

After the teen, these just became normal dual sided conversations rather than explanations 😂

When the guy said “mistakes... and people get sick”, he probably wasn’t talking about allergies, but he went with it anyway.

Me someone who actively trying to keep on topic of medical knowledge. A modern teen: p53 Me: furiously googling

Level 6: RU-vid commenter

Professionals: You know what this is? Me as college student: Absolutely not

I love how, when it got to talking to the expert, he started asking questions

First watched this video as a science-curious high schooler, now rewatching it as a junior molecular biology major who is actually doing CRISPR in the lab ❤

the more he goes up , the less he talks.

"Well I'm allergic to Penicillin and Azithromycin" WOA WOA HOLD UP THERE! I THOUGHT YOU WERE THE KID NOT THE GRADUATE STUDENT

CRIPR and what Alphafold 2 just did with protein folding is going to change so much of the biomedical sciences and so much more. It made my list of most amazing scientific and technological breakthroughs that happened in 2020 in my RU-vid video. This was really cool to watch the levels of understanding. So important to be able to explain things like this. Keep spreading the knowledge!

I love the progression of information in this video!! Well laid out

These 5 levels of difficulty videos are awesome.

I like how he changes his sitting position depending on the level. Also, the amount of information he's providing decreases by levels and it becomes more of a conversation than some kind of course. Great video!

Woah, I have a biology degree and I have to say, the college student they picked had a waaay better understanding of CRISPR than your average randomly picked bio student would. I have to assume that either he learned it really recently or he specialized into more molec bio/genetics study. Or he is just way smarter than me and the people I've been around!

Level 1: Very Short Level 2: Short Level 3: Long Level 4: Very Long Level 5: 9 min. 7 sec.

Why does a 14 year old know about p53 mutation... ? How can we have more 14 year olds like that?

By the time he got to level 4, they were explaining the concept to him.

Level 5: When Sam Smith altered his DNA and decided to be a scientist

As a Biology Major Undergrad, This is amazing!♥️ I kind of get some techniques how to explain concepts in Biology in the most simplest to more technical way♥️

I was able to comprehend every level with full understanding and i am only 5 months old. The secret to becoming an intellectual is watching Rick and Morty

I live how the expert gets half the video

He's so good at explaining this to kids.❤️

This makes me feel so proud that i could understand what they were saying at level 5. i'm first year master's degree in biotechnology and molecular pathology, and although i'm not quite a genetics expert but i guess it was enough to stay in line with them

His body language says a lot about him he's very ambitious willing to share and learn more but also he's really competitive

So we are just going to ignore all the paintings in the background that are on tripods? Really people? lol

Love how the grad student only talked about the ethics of it but barely any of the actual science

This is a great a way of understanding at many different difficulty levels. Was looking for these kind of videos and just found the right ones. One suggestion though, it would be great if entire narrative is woven and in question answers and part of a story. Currently the level jumps isn't smooth.

this guy is great. he really know how to start a conversation.

Yeah, that's right. Only expert level discussions involve Jurassic Park

I really love the idea of CRISPR and I am actually really excited to see the development of this and the application. Biology is so fascinating. I think CRISPR can go above and beyond what science has already done. It can help unlock things that were otherwise unknown to us, like what the one person was saying about the gene that controls eye color and height, it will help find those things that make us, who we are. It will not only help Cancer patients, but also find what causes Hyper and Hypothyroidism, what causes some people to have chemical imbalances, and maybe cure thing like depression and other disorders that are only controlled by medicine. That is another thing, what will application imply? My focus is mostly on the endless possibilities, I have several people in my life that have autoimmune disorders, and I can't help but think how CRISPR can help them, and maybe future generations. Yes, there will be side effects and the Ethics will have to be ironed out, but all in due time. When I say I am excited to learn more about this, I over the moon right now!!!

OMG Teigen is so cute! I love how cute his voice is. And he looks so adorable 😭😭💛

Level 6: Rick and Morty viewer

Thank you for having me on this! I loved working with all of you!!

I love what they said at the end about funding more basic research - there's too much attention right now on "one-hit wonder" papers that show positive results of something ground-breaking (many of which aren't even reproducible, anyway), and that's pushing out 1) research that shows no correlation/null hypothesis and 2) research that might not seem to go anywhere now, but (with further probing) could lead to something revolutionary down the line. Anyway, lovely video! I really enjoyed the different perspectives and points brought up with each person and how Dr. Sanjana made sure to still explain some of the terms used in the Level 5 conversation for the viewers - much appreciated!

Ilove that college student....he talked and he listened too! He shared his knowledge withoutshowing it off:))

LVL 6: RU-vid COMMENTERS "Do you know what CRISPR is?" "THEY'RE TURNING THE FROGS GAY!"

Omg who taught that child about p53? Bless her science teachers ...

I know he’s explaining about going in genomes and editing or increasing some parts of your DNA to help get rid of some health issues but embryonic stem cells and gene cloning popped into my mind too as he was talking about this new technology

I wish the video goes into more depth about the concept, how it works at the mechanical level, an update on the current research/break through/challenges, and their implications/applications in the near term (next 5-10 years). way to much proportion on ethics and re-creating species that went extinct at level 4 and 5, which was the language and complexity of level 2 and 3.

That blue cushion looks edited in.

Physicists explain one concept in 5 level of difficulty. Quantum physics

What’s pretty cool is that my high school dual credit professor (high school aged, college class) actually worked on the human genome project. She had lots of knowledge about genomes and how it can affect so many things in nature.

This is an interesting series. Please please pleasseeee continue it..Plzzzzzzz restart!

Funny when you're the age of Level 5 but knowledge of Level 1.

I love this series, especially how they don't dumb things down from the very first level of difficulty.

I'm a biology undergrad student and I'm so glad that not only did I understand level 5 easily, I found it fairly basic and general. :)

It's interesting how up to the grad student, he's talking about how great CRISPR is as an editing. With the expert he is talking more about kinks that have to be worked out and what the opportunities are...

You see how the biologists body language changed when the expert started talking 😂

The explanations just kept getting crisper and crisper...

@6:26 such an abrupt cut off

This is the coolest series of videos I've ever seen.

I'd love to see a linguistic version of this 😊 these videos are great, I love them

While the ethical considerations are important, I wanted more about how it actually works.

Love that we learn stuff explained in level 4 in grade 11 in Germany

That college student knew a lot more than people would have expected him to know. Actually every single person who were asked about CRISPR in the video had much more knowledge about biology/the subject than one should expect.

As a 9th grade biology teacher, I have enjoyed this so much! I am going to show it to my students.

Quantum computing or Quantum physics explained in 5 levels of difficulty.....That would really be interesting trust me.

the expert looks both intimidating and kind

I leaned about CRISPR in agriculture class around 4 months ago I’m so surprised not many people are talking about it

crispr is the coolest thing to come out of science in the last decade

Level 1: Biologist explains CRISPR to 7 year-old Level 2: Biologist explains CRISPR to 14 year-old Level 3: Collage student explains CRISPR to Biologist (who clarifies it a bit) Level 4: Biologist discusses ethical issues about CRISPR with grad student. Level 5: Biologist discusses CRISPR with expert (and explains some of the concepts they are talking about to the audience).

Animals don't have cell wall plants do, wow I'm so smart😤

This would’ve been really helpful if i watched this yesterday for my test