Biology beyond the genome | Denis Noble 

Denise Nobel is a true scientist. He is a joy to listen to and he is really a National treasure. Really his only purpose for doing this is to ensure that rational, logical, objective analysis of the data, and the conclusions that can be drawn from it, remains the focus of scientific inquiry, and that all humans reap the benefits of such knowledge so as to increase their understanding of the world that they live in and make better decisions as a species in their lives, their society and their public policies.

Get this guy together with Michael Levin. Very complementary understandings. :)

The year 1980 is a specific and Mystic year for promoting the study of the hole ADN and especially for Genoms. Thank you.

Very interesting Worth watching twice (tomorrow lunch)

I followed the link to see the rest of the lecture but got waylaid in a web site. Perhaps they could make the trail more discernable.

Great, thank you for the great talk

Thank you for sharing with us this interesting video..!!

Wow! This was fabulous!

As I study more and more Biology, I continue to lean more towards that DNA is just a memory created by cells to aid performing tasks with low error rates. Make no mistakes, these tasks are important, but still cells are the master (active) and DNA is the assistant (passive). I am glad Denis Noble gives a timely update to overthrow the dogmas in "standard" Biology.

Excellent....❤ thanks 🙏

Sir Thanks for very valuable knowledge 🌹

People in the background, quiet please. Respect the speaker!

I have been ranting about something similar for years! Starting to make the videos to explain the concept of the soul !

Thank you I am very interested on.

Interesting.

Of course epigenetics plays a role in our biology. I doubt there's any reasonable scientist who disputes that. However, the way that proteins and nucleic acids respond to their environments is still encoded in the DNA. DNA can be changed or introduced, as by viral transmission or random mutation, which can result in a change in the genome for a certain cell. Not all our cells in our own bodies have the same exact genome due to these sorts of changes. Ultimately, though, those cellular genomes dictate a cell's response to its environment.

Hi i'm Patrick Allen Andrews It was my evolution theory.Presented in 95 that turned out to be correct according to the science of DNA.

Homeboy indirectly calling out Richard Dawrkins lol

Wow - "Just because you get a Nobel Prize, doesn't mean people will listen to you." I wish this guy was in my family!

Are we going to get the entire lecture?

Loooove how he said three

A switch (protein binding to confirmation site) is a (if) statement, but it's also a "switch" statement (case1, case2, case3....) for molecules that bind to that confirmation site, with differential effect. if that's what you mean.

I used to think that the chances are very few for gamete to have mutuation and create phenomenal useful mutuation. May be like the speaker claims, there could be communication between gamete genome and body. Can anyone suggest some PAPERS THAT PROVE THAT.

Thank you! ❤

Is this article available in Hindi language??

I study Genomics (went to Johns Hopkins for it) and I also study the history of Biology from the Triassic to now and it is not understood by biologists. ONLY BIOLOGICAL CHEMICALS ARE CREATED BY ENZYMES. Only Bacteria create enzymes. CTAG are simply program codes...Even if the Gene is good they need to be methylated to turn on. I would love to discuss this because Drs do not realize the importance of Good Bacteria affect on the Cell TIGHT JUNCTIONS....all diseases are invasion and the membranes are the barrier. We have had success with Autism simply from Pro-bacteria and membrane supplements.

Loved him in the Italian Job.

Life as a logical sequence of actions in a cell doesn't work but it should.

The genome moves accidentally, which enables evolution. While environmental factors may play a role in how the genome changes, it is not the driving factor in the genome's natural predisposition to change. It can only affect the characteristics of that change.

cell is just a mechanism or is it ?

The genome is quantum. It’s not just in or off “switches”.

Let's now explore how we can apply logic, math, and physics to formalize the relationship between determinism and indeterminism in causality within the monadological framework. First, let's define our basic entities and relations: - Let M be the set of all monads (fundamental psychophysical entities). - Let T be a set of "time points" or "moments." - Let S be a function from M × T to some set of "states," where S(m, t) represents the state of monad m at time t. - Let C be a relation on M × M × T, where (m1, m2, t) ∈ C means monad m1 "causes" or "influences" monad m2 at time t. Now, let's formalize the idea of determinism and indeterminism in causality: - Determinism: ∀m ∈ M, ∀t ∈ T, S(m, t) is uniquely determined by {S(m', t') : (m', m, t') ∈ C}. - Indeterminism: ∃m ∈ M, ∃t ∈ T, such that S(m, t) is not uniquely determined by {S(m', t') : (m', m, t') ∈ C}. In other words, determinism means that the state of each monad at each time is uniquely determined by its causal influences, while indeterminism means that there are some monads whose states are not uniquely determined by their causal influences. We can formalize this further using the mathematical framework of graph theory and probability theory: - Let (M, E) be a directed graph, where E ⊆ M × M represents the "causal edges" between monads. - Let (Ω, F, P) be a probability space, where Ω represents the set of all possible "outcomes" or "histories," F is a σ-algebra on Ω, and P is a probability measure on F. - The determinism and indeterminism of causality can be expressed as: - Determinism: ∀m ∈ M, ∀t ∈ T, ∃f : Ω → S, such that S(m, t) = f(ω) for all ω ∈ Ω. - Indeterminism: ∃m ∈ M, ∃t ∈ T, such that ∀f : Ω → S, P({ω ∈ Ω : S(m, t) ≠ f(ω)}) > 0. Here, determinism is formalized as the existence of a function f that maps each possible outcome ω to a unique state for each monad at each time, while indeterminism is formalized as the non-existence of such a function (i.e., there are some monads whose states have a non-zero probability of differing from any given function). Finally, we can connect this to physics by noting that this formalism is compatible with both deterministic and indeterministic approaches to causality: - Deterministic models like classical mechanics describe the evolution of physical systems as uniquely determined by initial conditions and dynamical laws. - Indeterministic models like quantum mechanics describe the evolution of physical systems as inherently probabilistic, with outcomes determined only probabilistically by initial conditions and dynamical laws. The monadological framework accommodates both perspectives by treating determinism and indeterminism as emergent properties arising from the complex web of causal relations between fundamental monads. In summary, by using tools from logic, math (graph theory and probability theory), and physics (classical and quantum mechanics), we can formalize the both/and nature of determinism and indeterminism in causality within the monadological framework: - Causality is a relational structure arising from the web of causal influences between fundamental monads. - Causality exhibits both deterministic and indeterministic properties, depending on the scale and perspective of observation. - This formalism is compatible with both deterministic and indeterministic approaches to causality in physics. This showcases the potential of the monadological framework to provide a unified language for expressing and reconciling the complex, often seemingly contradictory nature of reality. By embracing a both/and perspective and drawing on the tools of logic, mathematics, and physics, we can develop a more nuanced and comprehensive understanding of the world and our place within it.

If we're allowed to...I would change or exchange the nucleus of other cell with each other to see whether it do something or not. Since smallest needle is born.

Immortality , who's first , you, not you or you.

11:30. When Denis says ‘accretion of chunks of protein’ I pretty sure he misspoke here as he should of said ‘accretion of chunks of DNA’..

i.e. A DNA or RNA sequence could be produced in a prebiotic natural goo, but that wouldn't make a cell. Simultaneously, the cell membrane would have to be produced. The probability is vanishing. Same goes for DNA-favorable mutations (what I thought was evolution). Right? The machinery of the cell would have to tell the DNA how to mutate. Is the cell's machinery conscious?

always amazing to me when a cell phone rings more than once in an audience. if that happens, the owner of the cell phone should be physically silenced for a week

if you understood lfe would you kill it ? or make things to.

is this really rational observation

So Lamark was right?

Miss and mr understanding

am I alone in that background noise

While the lipids of a cell are inherited so are the proteins and polynucleotides to begin with. The maintenance and increase ( growth ) of all parts of a cells' anatomy are dependent on Cricks' dogma of DNA to RNA to PROTEIN which evolved into being and was not present at life's origin as well as nutrition. Noble is wrong to go after Dawkins' idea of the selfish gene because it's almost right, in fact it's the polynucleotide itself whether a gene or non coding that is a selfish little predator , using nutrients in its ' environment to grow. All spelled out in " From Chemistry to Life on Earth " by Austin Macauley Publishers by Barask Paraskevopoulos . Publication date 21 June 2024. 292 references 267 pages- illustrated

People who look like people live forever , they're clever.

If you don't clarify what the information process is in life (information theory) you can say everything and the opposite of everything.

Except for *mature* red blood cells

Ayurveda knew this 5,000 or so years ago!😊

And all these incredibly detailed complicated programming that we still don't understand was created out of nothing or chance 😂😂😂

Everything is becoming a show .Of course one must get the upcoming book in.

someone knows all your answers , they're keeping mumb though

Ebt 101 what happen

ତଥାପି ବୁଝି ପାରୁ ନାହିଁ ବା ବିଶ୍ୱାସ କରି ପାରୁ ନାହିଁ।

Covid 19 as an intracellular multitool , yes,no ,fade out ?

This man is an example of how the phenomenon of "idiot savant" can produce genius. In the simple idiot savant case, a man can suffer developmental damage, and yet have photographic memory. In less specific cases, this phenomenon takes on the form of specialization in a particular area of science, art, music, or business. And while this man is by no means a genius, he is good at what he is talking about.

A wealth of data from 23 AND ME clearly demonstrates that a persons personality is largely rooted in their genetics. That’s not to say that environment doesn’t act as a modulator, but it’s not the main thing. I feel sorry for this old gentleman.

This is why you have stuff like covid19 in your lives , covid is something that should not exist but does.

A study comes to mind in which they were observing bacteria and viruses helping one anothare you familiar wouldn't that be a selfish endeavor

If anyone is gonna call their audience stupid, they better do it in a British accent. 😂

You're having problems making computer simulations of metabolic activity. maybe you never will.

So what is the message? The signature in the cell😂😂😂😂😂😂😂😂😂😂😂😂😂😂🎉🎉🎉😂😂😂

Antiscience without saying directly

The statement of the Holy Quran is that humanbeing is as to as in the universe .And the structuer of human kind is also as like the statement of the holly spiritull mentiones .Allah challeged his All Anbia that you asked the believers of your nations is there any human being or rasool who create such beautifull structuer of humans that work himself action for his life .as you know better than us .Then why prffer the theory of Darwen .We say that human kind slowly slowly find the develop Ent in cultuer .

I’m not familiar with this channel. Is this legit science or pseudoscience made up bs?

Dum

STAY AWAY FROM OUR GENES.

Oh gosh but I doubt he is right on this you know as soon you think you know it seems to change…..

The ORDER of genes is NOT the ORGANIZATION of genes. Knowing the sound of each piano' s digit you can not know the sinphony!!!

@ph7.0🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉🎉