Please note that the three signals of T cell activation have slightly changed since I made this video. Signal 1 is the interaction between the TCR and the MHC molecule (stayed the same). Signal 2 is the co-stimulation, i.e. the interaction between B7 and CD 28 (stayed the same as well). As a consequence of signal 1 and 2, the T cell starts making IL-2, which binds to the IL-2 receptor in an autocrine fashion and drives the proliferation of the T-cell (this was formerly the signal 3). Signal 3 is now the secretion of cytokines by the antigen-presenting cell which will determine the differentiation of the CD4 T cell (i.e. the production of IL-12 and IFNg will drive Th1, IL-4 will drive Th2, TGFb and IL-6 will drive Th17 and TGFb will drive Tregs).
Ok so the dendritic cell represents something. What does it mean that a T cell recognises that. Is it so that the set of naive T cells is so big that there is always one that fits nicely to any given antigen. Or is something variable happening at the T cell receptor?
Does Womezon Remedy really work? I notice a lot of people keep on talking about Womezon Remedy. But I'm not sure if it's good enough to cleanse your bacterial vaginosis issue naturally .
